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PhD thesis defense and final exam

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Conclusion of the doctoral program

End for 37th cycle doctoral students: September 30, 2024 End for 37th cycle PON scholarship holders: December 31, 2024

Exceptions are doctoral students who are beneficiaries of extensions and doctoral students in suspension recovery, for whom the deadline is automatically postponed for the period corresponding to the recovery or extension.

The doctoral student receives an email from the Office containing detailed information on the requirements for taking the final examination.

Academic Board approval and evaluators

At the end of the course, the doctoral student submits some documents to the Academic Board, including the thesis and any request for embargo or secrecy of parts. The Academic Board, upon receipt of the documents, makes a decision on the admission of the doctoral student to the final examination and appoints two evaluators to pass judgment on the thesis, proposing its admission for public discussion or postponement for a period not exceeding six months. At this point the thesis is ready to be discussed.

Administrative Procedures

Within 15 days after the conclusion of the course, the doctoral student (see calendar), through the appropriate computer procedure, must submit a final examination application, as per the instructions provided by email from the Office. Once in possession of the final version of the thesis, the doctoral student uploads it, at least 20 days before the discussion, in his/her Reserved Area. The PhD Coordinator or the supervisor will receive an automatic email requesting validation of the thesis, which is necessary for the purposes of the thesis discussion.

Schedule of deadlines

Thesis discussion

The thesis is discussed publicly before a committee.

The Coordinator notifies the doctoral students of the names of the members of the Commission and the deadlines by which to send them copies of the thesis. The Commission, at the end of the discussion approves or rejects the thesis and proposes or does not propose to the Rector the conferment of the doctoral degree.

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Regulations and suggestions about the thesis work from the PhD School

Forms to be admitted to the final defence of the thesis

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We suggest to write your thesis in A4 or A5 format; however, different format will be allowed.

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How Do I Prepare for a Successful Defence?

Vivas and Presentations

  • First Online: 19 October 2023

Cite this chapter

thesis defence italiano

  • Sue Reeves   ORCID: orcid.org/0000-0002-3017-0559 3 &
  • Bartek Buczkowski   ORCID: orcid.org/0000-0002-4146-3664 4  

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Once you have submitted your dissertation, you may be asked to do a defence of your dissertation. This could be in the form of an oral presentation, a poster presentation of your findings, or you could be invited to a viva voce. Vivas, as they are usually known, are particularly common for research degrees such as MPhils or PhDs and are essentially a verbal defence of your thesis that is conducted in an interview style format. At a minimum, the viva is a way of checking you authored the thesis yourself and understand the detail, but it is also an opportunity to discuss your research findings and interpretations in depth with experts. Preparation is key for defending your thesis in a viva or a presentation format. With a bit of groundwork, you could even enjoy the discussion, after all the thesis is the culmination of all your hard work, and no one knows it better than you.

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Ratcliffe R (2015) How to survive a PhD viva: 17 top tips. https://www.theguardian.com/higher-education-network/2015/jan/08/how-to-survive-a-phd-viva-17-top-tips. Accessed 3 Mar 2023

Further Reading

Levin P, Topping G (2006) Perfect presentations. Open University Press

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Smith P (2014) The PhD viva: how to prepare for your oral examination. Macmillan, New York

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About this chapter

Reeves, S., Buczkowski, B. (2023). How Do I Prepare for a Successful Defence?. In: Mastering Your Dissertation. Springer, Cham. https://doi.org/10.1007/978-3-031-41911-9_14

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thesis defence italiano

Preparing For Your Dissertation Defense

13 Key Questions To Expect In The Viva Voce

By: Derek Jansen (MBA) & David Phair (PhD) . Reviewed By: Dr Eunice Rautenbach | June 2021

Preparing for your dissertation or thesis defense (also called a “viva voce”) is a formidable task . All your hard work over the years leads you to this one point, and you’ll need to defend yourself against some of the most experienced researchers you’ve encountered so far.

It’s natural to feel a little nervous.

In this post, we’ll cover some of the most important questions you should be able to answer in your viva voce, whether it’s for a Masters or PhD degree. Naturally, they might not arise in exactly the same form (some may not come up at all), but if you can answer these questions well, it means you’re in a good position to tackle your oral defense.

Dissertation and thesis defense 101

Viva Voce Prep: 13 Essential Questions

  • What is your study about and why did you choose to research this in particular?
  • How did your research questions evolve during the research process?
  • How did you decide on which sources to include in your literature review?
  • How did you design your study and why did you take this approach?
  • How generalisable and valid are the findings?
  • What were the main shortcomings and limitations created by your research design?
  • How did your findings relate to the existing literature?
  • What were your key findings in relation to the research questions?
  • Were there any findings that surprised you?
  • What biases may exist in your research?
  • How can your findings be put into practice?
  • How has your research contributed to current thinking in the field?
  • If you could redo your research, how would you alter your approach?

#1: What is your study about and why did you choose to research this in particular?

This question, a classic party starter, is pretty straightforward.

What the dissertation or thesis committee is assessing here is your ability to clearly articulate your research aims, objectives and research questions in a concise manner. Concise is the keyword here – you need to clearly explain your research topic without rambling on for a half-hour. Don’t feel the need to go into the weeds here – you’ll have many opportunities to unpack the details later on.

In the second half of the question, they’re looking for a brief explanation of the justification of your research. In other words, why was this particular set of research aims, objectives and questions worth addressing? To address this question well in your oral defense, you need to make it clear what gap existed within the research and why that gap was worth filling.

#2: How did your research questions evolve during the research process?

Good research generally follows a long and winding path . It’s seldom a straight line (unless you got really lucky). What they’re assessing here is your ability to follow that path and let the research process unfold.

Specifically, they’ll want to hear about the impact that the literature review process had on you in terms of shaping the research aims, objectives and research questions . For example, you may have started with a certain set of aims, but then as you immersed yourself in the literature, you may have changed direction. Similarly, your initial fieldwork findings may have turned out some unexpected data that drove you to adjust or expand on your initial research questions.

Long story short – a good defense involves clearly describing your research journey , including all the twists and turns. Adjusting your direction based on findings in the literature or the fieldwork shows that you’re responsive , which is essential for high-quality research.

You will need to explain the impact of your literature review in the defense

#3: How did you decide on which sources to include in your literature review?

A comprehensive literature review is the foundation of any high-quality piece of research. With this question, your dissertation or thesis committee are trying to assess which quality criteria and approach you used to select the sources for your literature review.

Typically, good research draws on both the seminal work in the respective field and more recent sources . In other words, a combination of the older landmark studies and pivotal work, along with up-to-date sources that build on to those older studies. This combination ensures that the study has a rock-solid foundation but is not out of date.

So, make sure that your study draws on a mix of both the “classics” and new kids on the block, and take note of any major evolutions in the literature that you can use as an example when asked this question in your viva voce.

#4: How did you design your study and why did you take this approach?

This is a classic methodological question that you can almost certainly expect in some or other shape.

What they’re looking for here is a clear articulation of the research design and methodology, as well as a strong justification of each choice . So, you need to be able to walk through each methodological choice and clearly explain both what you did and why you did it. The why is particularly important – you need to be able to justify each choice you made by clearly linking your design back to your research aims, objectives and research questions, while also taking into account practical constraints.

To ensure you cover every base, check out our research methodology vlog post , as well as our post covering the Research Onion .

You have to justify every choice in your dissertation defence

#5: How generalizable and valid are the findings?

This question is aimed at specifically digging into your understanding of the sample and how that relates to the population, as well as potential validity issues in your methodology.

To answer question this well, you’ll need to critically assess your sample and findings and consider if they truly apply to the entire population, as well as whether they assessed what they set out to. Note that there are two components here – generalizability and validity . Generalizability is about how well the sample represents the population. Validity is about how accurately you’ve measured what you intended to measure .

To ace this part of your dissertation defense, make sure that you’re very familiar with the concepts of generalizability , validity and reliability , and how these apply to your research. Remember, you don’t need to achieve perfection – you just need to be aware of the strengths and weaknesses of your research (and how the weaknesses could be improved upon).

Need a helping hand?

thesis defence italiano

#6: What were the main shortcomings and limitations created by your research design?

This question picks up where the last one left off.

As I mentioned, it’s perfectly natural that your research will have shortcomings and limitations as a result of your chosen design and methodology. No piece of research is flawless. Therefore, a good dissertation defense is not about arguing that your work is perfect, but rather it’s about clearly articulating the strengths and weaknesses of your approach.

To address this question well, you need to think critically about all of the potential weaknesses your design may have, as well as potential responses to these (which could be adopted in future research) to ensure you’re well prepared for this question. For a list of common methodological limitations, check out our video about research limitations here .

#7: How did your findings relate to the existing literature?

This common dissertation defense question links directly to your discussion chapter , where you would have presented and discussed the findings in relation to your literature review.

What your dissertation or thesis committee is assessing here is your ability to compare your study’s findings to the findings of existing research . Specifically, you need to discuss which findings aligned with existing research and which findings did not. For those findings that contrasted against existing research, you should also explain what you believe to be the reasons for this.

As with many questions in a viva voce, it’s both the what and the why that matter here. So, you need to think deeply about what the underlying reasons may be for both the similarities and differences between your findings and those of similar studies.

Your dissertation defense needs to compare findings

#8: What were your key findings in relation to the research questions?

This question is similar to the last one in that it too focuses on your research findings. However, here the focus is specifically on the findings that directly relate to your research questions (as opposed to findings in general).

So, a good way to prepare for this question is to step back and revisit your research questions . Ask yourself the following:

  • What exactly were you asking in those questions, and what did your research uncover concerning them?
  • Which questions were well answered by your study and which ones were lacking?
  • Why were they lacking and what more could be done to address this in future research?

Conquering this part dissertation defense requires that you focus squarely on the research questions. Your study will have provided many findings (hopefully!), and not all of these will link directly to the research questions. Therefore, you need to clear your mind of all of the fascinating side paths your study may have lead you down and regain a clear focus on the research questions .

#9: Were there any findings that surprised you?

This question is two-pronged.

First, you should discuss the surprising findings that were directly related to the original research questions . Going into your research, you likely had some expectations in terms of what you would find, so this is your opportunity to discuss the outcomes that emerged as contrary to what you initially expected. You’ll also want to think about what the reasons for these contrasts may be.

Second, you should discuss the findings that weren’t directly related to the research questions, but that emerged from the data set . You may have a few or you may have none – although generally there are a handful of interesting musings that you can glean from the data set. Again, make sure you can articulate why you find these interesting and what it means for future research in the area.

What the committee is looking for in this type of question is your ability to interpret the findings holistically and comprehensively , and to respond to unexpected data. So, take the time to zoom out and reflect on your findings thoroughly.

Discuss the findings in your defense

#10: What biases may exist in your research?

Biases… we all have them.

For this question, you’ll need to think about potential biases in your research , in the data itself but also in your interpretation of the data. With this question, your committee is assessing whether you have considered your own potential biases and the biases inherent in your analysis approach (i.e. your methodology). So, think carefully about these research biases and be ready to explain how these may exist in your study.

In an oral defense, this question is often followed up with a question on how the biases were mitigated or could be mitigated in future research. So, give some thought not just to what biases may exist, but also the mitigation measures (in your own study and for future research).

#11: How can your findings be put into practice?

Another classic question in the typical viva voce.

With this question, your committee is assessing your ability to bring your findings back down to earth and demonstrate their practical value and application. Importantly, this question is not about the contribution to academia or the overall field of research (we’ll get to that next) – it is specifically asking about how this newly created knowledge can be used in the real world.

Naturally, the actionability of your findings will vary depending on the nature of your research topic. Some studies will produce many action points and some won’t. If you’re researching marketing strategies within an industry, for example, you should be able to make some very specific recommendations for marketing practitioners in that industry.

To help you flesh out points for this question, look back at your original justification for the research (i.e. in your introduction and literature review chapters). What were the driving forces that led you to research your specific topic? That justification should help you identify ways in which your findings can be put into practice.

#12: How has your research contributed to current thinking in the field?

While the previous question was aimed at practical contribution, this question is aimed at theoretical contribution . In other words, what is the significance of your study within the current body of research? How does it fit into the existing research and what does it add to it?

This question is often asked by a field specialist and is used to assess whether you’re able to place your findings into the research field to critically convey what your research contributed. This argument needs to be well justified – in other words, you can’t just discuss what your research contributed, you need to also back each proposition up with a strong why .

To answer this question well, you need to humbly consider the quality and impact of your work and to be realistic in your response. You don’t want to come across as arrogant (“my work is groundbreaking”), nor do you want to undersell the impact of your work. So, it’s important to strike the right balance between realistic and pessimistic .

This question also opens the door to questions about potential future research . So, think about what future research opportunities your study has created and which of these you feel are of the highest priority.

Discuss your contribution in your thesis defence

#13: If you could redo your research, how would you alter your approach?

This question is often used to wrap up a viva voce as it brings the discussion full circle.

Here, your committee is again assessing your ability to clearly identify and articulate the limitations and shortcomings of your research, both in terms of research design and topic focus . Perhaps, in hindsight, it would have been better to use a different analysis method or data set. Perhaps the research questions should have leaned in a slightly different direction. And so on.

This question intends to assess whether you’re able to look at your work critically , assess where the weaknesses are and make recommendations for the future . This question often sets apart those who did the research purely because it was required, from those that genuinely engaged with their research. So, don’t hold back here – reflect on your entire research journey ask yourself how you’d do things differently if you were starting with a  blank canvas today.

Recap: The 13 Key Dissertation Defense Questions

To recap, here are the 13 questions you need to be ready for to ace your dissertation or thesis oral defense:

As I mentioned, this list of dissertation defense questions is certainly not exhaustive – don’t assume that we’ve covered every possible question here. However, these questions are quite likely to come up in some shape or form in a typical dissertation or thesis defense, whether it’s for a Master’s degree, PhD or any other research degree. So, you should take the time to make sure you can answer them well.

If you need assistance preparing for your dissertation defense or viva voce, get in touch with us to discuss 1-on-1 coaching. We can critically review your research and identify potential issues and responses, as well as undertake a mock oral defense to prepare you for the pressures and stresses on the day.

thesis defence italiano

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14 Comments

Jalla Dullacha

Very interesting

Fumtchum JEFFREY

Interesting. I appreciate!

Dargo Haftu

Really appreciating

My field is International Trade

Abera Gezahegn

Interesting

Peter Gumisiriza

This is a full course on defence. I was fabulously enlightened and I gained enough confidence for my upcoming Masters Defence.

There are many lessons to learn and the simplicity in presentationmakes thee reader say “YesI can”

Milly Nalugoti

This is so helping… it has Enlightened me on how to answer specific questions. I pray to make it through for my upcoming defense

Derek Jansen

Lovely to hear that 🙂

bautister

Really educative and beneficial

Tweheyo Charles

Interesting. On-point and elaborate. And comforting too! Thanks.

Ismailu Kulme Emmanuel

Thank you very much for the enlightening me, be blessed

Gladys Oyat

Thankyou so much. I am planning to defend my thesis soon and I found this very useful

Augustine Mtega

Very interesting and useful to all masters and PhD students

Gonzaga

Wow! this is enlightening. Thanks for the great work.

grace pahali

Thank you very much ,it will help me My Master Degree. and am comfortable to my defense.

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How to prepare an excellent thesis defense

Thesis defence

What is a thesis defense?

How long is a thesis defense, what happens at a thesis defense, your presentation, questions from the committee, 6 tips to help you prepare for your thesis defense, 1. anticipate questions and prepare for them, 2. dress for success, 3. ask for help, as needed, 4. have a backup plan, 5. prepare for the possibility that you might not know an answer, 6. de-stress before, during, and after, frequently asked questions about preparing an excellent thesis defense, related articles.

If you're about to complete, or have ever completed a graduate degree, you have most likely come across the term "thesis defense." In many countries, to finish a graduate degree, you have to write a thesis .

A thesis is a large paper, or multi-chapter work, based on a topic relating to your field of study.

Once you hand in your thesis, you will be assigned a date to defend your work. Your thesis defense meeting usually consists of you and a committee of two or more professors working in your program. It may also include other people, like professionals from other colleges or those who are working in your field.

During your thesis defense, you will be asked questions about your work. The main purpose of your thesis defense is for the committee to make sure that you actually understand your field and focus area.

The questions are usually open-ended and require the student to think critically about their work. By the time of your thesis defense, your paper has already been evaluated. The questions asked are not designed so that you actually have to aggressively "defend" your work; often, your thesis defense is more of a formality required so that you can get your degree.

  • Check with your department about requirements and timing.
  • Re-read your thesis.
  • Anticipate questions and prepare for them.
  • Create a back-up plan to deal with technology hiccups.
  • Plan de-stressing activities both before, and after, your defense.

How long your oral thesis defense is depends largely on the institution and requirements of your degree. It is best to consult your department or institution about this. In general, a thesis defense may take only 20 minutes, but it may also take two hours or more. The length also depends on how much time is allocated to the presentation and questioning part.

Tip: Check with your department or institution as soon as possible to determine the approved length for a thesis defense.

First of all, be aware that a thesis defense varies from country to country. This is just a general overview, but a thesis defense can take many different formats. Some are closed, others are public defenses. Some take place with two committee members, some with more examiners.

The same goes for the length of your thesis defense, as mentioned above. The most important first step for you is to clarify with your department what the structure of your thesis defense will look like. In general, your thesis defense will include:

  • your presentation of around 20-30 minutes
  • questions from the committee
  • questions from the audience (if the defense is public and the department allows it)

You might have to give a presentation, often with Powerpoint, Google slides, or Keynote slides. Make sure to prepare an appropriate amount of slides. A general rule is to use about 10 slides for a 20-minute presentation.

But that also depends on your specific topic and the way you present. The good news is that there will be plenty of time ahead of your thesis defense to prepare your slides and practice your presentation alone and in front of friends or family.

Tip: Practice delivering your thesis presentation in front of family, friends, or colleagues.

You can prepare your slides by using information from your thesis' first chapter (the overview of your thesis) as a framework or outline. Substantive information in your thesis should correspond with your slides.

Make sure your slides are of good quality— both in terms of the integrity of the information and the appearance. If you need more help with how to prepare your presentation slides, both the ASQ Higher Education Brief and James Hayton have good guidelines on the topic.

The committee will ask questions about your work after you finish your presentation. The questions will most likely be about the core content of your thesis, such as what you learned from the study you conducted. They may also ask you to summarize certain findings and to discuss how your work will contribute to the existing body of knowledge.

Tip: Read your entire thesis in preparation of the questions, so you have a refreshed perspective on your work.

While you are preparing, you can create a list of possible questions and try to answer them. You can foresee many of the questions you will get by simply spending some time rereading your thesis.

Here are a few tips on how to prepare for your thesis defense:

You can absolutely prepare for most of the questions you will be asked. Read through your thesis and while you're reading it, create a list of possible questions. In addition, since you will know who will be on the committee, look at the academic expertise of the committee members. In what areas would they most likely be focused?

If possible, sit at other thesis defenses with these committee members to get a feel for how they ask and what they ask. As a graduate student, you should generally be adept at anticipating test questions, so use this advantage to gather as much information as possible before your thesis defense meeting.

Your thesis defense is a formal event, often the entire department or university is invited to participate. It signals a critical rite of passage for graduate students and faculty who have supported them throughout a long and challenging process.

While most universities don't have specific rules on how to dress for that event, do regard it with dignity and respect. This one might be a no-brainer, but know that you should dress as if you were on a job interview or delivering a paper at a conference.

It might help you deal with your stress before your thesis defense to entrust someone with the smaller but important responsibilities of your defense well ahead of schedule. This trusted person could be responsible for:

  • preparing the room of the day of defense
  • setting up equipment for the presentation
  • preparing and distributing handouts

Technology is unpredictable. Life is too. There are no guarantees that your Powerpoint presentation will work at all or look the way it is supposed to on the big screen. We've all been there. Make sure to have a plan B for these situations. Handouts can help when technology fails, and an additional clean shirt can save the day if you have a spill.

One of the scariest aspects of the defense is the possibility of being asked a question you can't answer. While you can prepare for some questions, you can never know exactly what the committee will ask.

There will always be gaps in your knowledge. But your thesis defense is not about being perfect and knowing everything, it's about how you deal with challenging situations. You are not expected to know everything.

James Hayton writes on his blog that examiners will sometimes even ask questions they don't know the answer to, out of curiosity, or because they want to see how you think. While it is ok sometimes to just say "I don't know", he advises to try something like "I don't know, but I would think [...] because of x and y, but you would need to do [...] in order to find out.” This shows that you have the ability to think as an academic.

You will be nervous. But your examiners will expect you to be nervous. Being well prepared can help minimize your stress, but do know that your examiners have seen this many times before and are willing to help, by repeating questions, for example. Dora Farkas at finishyourthesis.com notes that it’s a myth that thesis committees are out to get you.

Two common symptoms of being nervous are talking really fast and nervous laughs. Try to slow yourself down and take a deep breath. Remember what feels like hours to you are just a few seconds in real life.

  • Try meditational breathing right before your defense.
  • Get plenty of exercise and sleep in the weeks prior to your defense.
  • Have your clothes or other items you need ready to go the night before.
  • During your defense, allow yourself to process each question before answering.
  • Go to dinner with friends and family, or to a fun activity like mini-golf, after your defense.

Allow yourself to process each question, respond to it, and stop talking once you have responded. While a smile can often help dissolve a difficult situation, remember that nervous laughs can be irritating for your audience.

We all make mistakes and your thesis defense will not be perfect. However, careful preparation, mindfulness, and confidence can help you feel less stressful both before, and during, your defense.

Finally, consider planning something fun that you can look forward to after your defense.

It is completely normal to be nervous. Being well prepared can help minimize your stress, but do know that your examiners have seen this many times before and are willing to help, by repeating questions for example if needed. Slow yourself down, and take a deep breath.

Your thesis defense is not about being perfect and knowing everything, it's about how you deal with challenging situations. James Hayton writes on his blog that it is ok sometimes to just say "I don't know", but he advises to try something like "I don't know, but I would think [...] because of x and y, you would need to do [...] in order to find out".

Your Powerpoint presentation can get stuck or not look the way it is supposed to do on the big screen. It can happen and your supervisors know it. In general, handouts can always save the day when technology fails.

  • Dress for success.
  • Ask for help setting up.
  • Have a backup plan (in case technology fails you).
  • Deal with your nerves.

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  • Presentations

How to Start and Give a Great Thesis Defense Presentation

Sarah Joy

To complete a graduate degree, you'll likely need to create a thesis defense presentation. You must complete a thesis to finish many graduate degree programs. 

It's important to have an impressive thesis defense presentation.

A thesis is a paper where you explore a topic in depth that's related to what you’ve studied. After completing your thesis paper, you will be asked to defend it through a presentation.

You give this thesis defense in a meeting with a panel of two or more professors in your program. The panel could include other professionals related to your field.

In your thesis defense presentation, you will be asked questions about your topic. The purpose of the questions is to get you to think deeply about your work, so the questions could be open-ended.

To create a thesis defense presentation, you need to know how to make a thesis presentation and how to start your thesis defense. Keep reading to find out more about thesis defense presentations.

How to Structure Your PPT for Thesis Defense

It's just as important to start your presentation strong as it is to end strong.

Thesis defense presentations can vary in length. They can be 20 minutes long or two hours long. It depends on how much time is allowed for your presentation and questions.

Talk to your professor to find out how much time is set aside for your presentation. Your thesis defense presentation will be unique to your thesis. But a good presentation includes the following structure:

  • Title . You need a title just as your research paper needed a title. The title slide will include the information that you’d include on your paper title. This information can include the title, your name, your school, and course name.
  • Introduction . Just like most presentations, your thesis defense presentation should include an introduction slide. This slide should have the topic of your thesis and the question that your presentation answers. It should also include any objections to your research and the answer you’ll be defending in your thesis presentation.
  • Literature Review . Next, create two or more slides with a review of the literature used in your research. It doesn’t need to be a complete bibliography. Although you do need to cite your sources, these slides should include your most relevant sources.
  • Methodology . These slides in your thesis presentation are where you describe what method you used and an explanation of why you chose that method. If you've got some original research, include the details of that research and how you analyzed the data that you got from that research.
  • Results . Some of the most important slides of your PPT for thesis defense contain the results of your research. This should include a description of the data you collected by researching and the results of your data analysis. You also should highlight what your most noteworthy finding was.
  • Discussion . These slides of your PPT for thesis defense need to include your research results. Also, show how the results support your argument and how it relates to your original question.
  • Conclusion . The conclusion thesis presentation slides should restate your original research questions, show the results of your research, and suggest future research and any final recommendations.
  • Ending Slide . The ending slides of your thesis defense presentation are where you add an interesting fact, quote, gif, or hypothetical question. The point is to get your audience to continue to think about your topic while also grabbing their attention. You want your presentation to be memorable.

How to Make a Thesis Presentation

After you’ve seen what the structure of a thesis defense presentation is, there are some more tips that you can follow. Here are tips on how to create a thesis defense presentation:

1. Define Your Concept

When you start with a template you're starting with a good base.

After choosing which template to use, the next step is to choose the concept of your thesis defense presentation. Your concept should be relevant to your thesis. To have a fully rounded concept, try to make your presentation templates design relevant to your thesis topic.

Before working on your defense, think about the message you want to convey. This will help you choose elements such as font images and a theme that'll be cohesive.

2. Know Your Audience

Most people give their thesis defense presentation to an academic panel. This panel will look to see if you've developed a thorough understanding of your topic and thesis. They’ll also be looking to see if you've got a solid foundation for your argument.

This is why your presentation is important. You don’t want a sloppy presentation because it can give the impression of laziness and that you don’t care about your presentation. So, choose all aspects of your presentation carefully.

3. Keep Your Slides Focused   

Focused slides are less overwhelming for the audience.

Part of giving a good thesis presentation is to have focused slides. This means that you don’t want to have too much information on a slide. It’s best to follow the rule of one point per slide. If you've got too much on a single slide, it can be hard for the audience to follow you.

4. Structure Your Presentation

After you’ve chosen your concept, it's time to structure the content of your thesis. When structuring your information, you want to show that you understand the subject matter and that you're organized.

5. Less Is More

Less elements on a slide makes it easier for an audience to focus on your point.

Each slide should have enough information that you can make your point. It’s important that your audience listens more than they read. By speaking, you show your audience that you know the topic you’re presenting on. So, when creating your slides, remember that less is more.

6. Consider Your Typography

After choosing your thesis presentation subject, consider what typography to use. Your typography should create an impact without distracting from your topic.

When considering your typography, consider your text's colors. Your text's colors should contrast with your slide's background. If the text doesn’t contrast well, it can distract the audience, causing them not to pay attention as you speak.

7. Stick to Important Data

Don't overwhelm the audience with a large amount of data. Stick to important data.

Include data that'll strengthen your argument. Your data should also show that you’ve researched your thesis. If you can, add visuals that are relevant to your data. Visuals stimulate your brain and can increase how fast you process information. So, including relevant visuals can make your data easier to process and remember.

8. Consistency Is Key

When thinking about how to make a thesis presentation, think about consistency. For an impressive presentation, your presentation should flow well. It’s easier to have consistency when using a template because it’s already designed by a professional.

Check your finished presentation for consistency. This means making sure all your titles on slides are the same font and font size. Also, make sure that your body text is consistent throughout.

9. Explain Your Thesis

The most important part of your thesis defense presentation is explaining your thesis.

The next step in how to make a thesis presentation is to explain your thesis in great detail. The first part of this is your methodology slide . This is where you explain what method you used for your research, why you chose the topic, and how you conducted your research.

For this part of your thesis, chart and tables in your presentation are helpful in explaining data. In this section, keep your text minimal to let the chart, graphs, and data stand out. 

Next, tell the audience what the data means. Infographics are a great option to use in this section. Infographics and icons can quickly and simply show your message.

10. End Your Thesis

The last section of your thesis presentation is where you end it. Make your ending memorable to keep your audience thinking.

In your conclusion, overview your thesis topic and remind the audience of the answer that your research proved. Next, cover the important research points you want your audience to remember. A slide with icons is a great way to do this. Also, address your shortcomings in your research and how there can be improvements in future research.

Finally, use some more presentation tips by reading this helpful article:

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Way With Words

The 10 Key Components of a Successful Thesis Defence Presentation

Sep 27, 2023 | Research FAQs

What are the Key Components of a Successful Thesis Defence Presentation?

The culmination of years of rigorous research, analysis, and academic dedication is often encapsulated in a single event – a successful thesis defence presentation. This pivotal moment in an academic journey can be both exhilarating and nerve-wracking. Success hinges on a well-prepared and effectively delivered presentation. In this comprehensive guide, we will delve into the key components of a successful thesis defence presentation, equipping you with the knowledge and insights necessary to navigate this critical milestone in your academic career.

10 Key Strategies To Defend Your Thesis

#1 clearly define your statement of thesis.

At the heart of every successful thesis defence presentation lies a well-articulated statement of thesis. This concise and focused sentence or two should encapsulate the core question or problem your research addresses. Peer review, a critical evaluation of your work by experts in the field, often commences with a thorough assessment of the clarity and relevance of your thesis statement. It is the compass that guides your entire presentation.

successful thesis defence define

The statement of thesis serves as the cornerstone of an entire successful thesis defence presentation, and its importance cannot be overstated. This concise and focused sentence or two should encapsulate the core question or problem your research addresses. Think of it as the spark that ignites the intellectual journey you’re about to take your audience on.

When you consider the peer review process, it becomes clear that the experts in your field are like seasoned explorers, setting out on an intellectual expedition through your work. And where does their journey begin? With your thesis statement. It acts as the compass that guides their critical evaluation. They venture into the depths of your research, often commencing with a meticulous assessment of the clarity and relevance of your thesis statement. It’s not merely a formality; it’s a critical checkpoint to ensure that your compass is finely tuned and aligned with the path you’ve forged.

#2 Comprehensive Literature Review

A robust literature review demonstrates your understanding of the existing body of knowledge in your field. This component of your presentation should not merely summarise relevant literature but critically analyse it. Peer-reviewed journals, academic databases, and scholarly publications are invaluable resources for conducting a thorough literature review. Clearly demonstrate how your research fits into the existing landscape and adds a new dimension to the field.

Your literature review isn’t just a bibliography; it’s the evidence of your mastery over the existing body of knowledge in your field. It should be robust, showcasing your understanding and critical thinking abilities. Think of it as a treasure trove of insights from the minds of scholars who have paved the way before you.

Peer-reviewed journals, academic databases, and scholarly publications are the maps to this treasure trove. They are invaluable resources for conducting a thorough literature review. But remember, your role is not merely that of a summariser; you are an interpreter. Your presentation should not merely summarise relevant literature but critically analyse it. Imagine yourself as an art critic, dissecting each brushstroke to reveal the masterpiece that is your research. Show the audience how your research fits into the existing landscape and adds a new dimension to the field, like an artist contributing a unique piece to a gallery.

#3 Methodology and Data Collection

Describe in detail the methodologies employed in your research, addressing questions such as: How did you collect data? What tools or instruments did you use? How did you ensure the validity and reliability of your data? Peer review often scrutinises the rigor of your research methods, so be prepared to defend your choices and demonstrate their appropriateness for your study.

Your methodology is the blueprint of your research, and the data you collect are the bricks that build your thesis. This section deserves meticulous attention and clarity. Describe in detail the methodologies employed in your research. Address questions such as: How did you collect data? What tools or instruments did you use? How did you ensure the validity and reliability of your data? Think of it as the architectural plans that ensure your thesis stands tall and sturdy.

Keep in mind that peer review often scrutinises the rigor of your research methods. It’s like having a team of experienced builders inspecting your construction site for structural integrity. Be prepared to defend your choices and demonstrate their appropriateness for your study. You’re not just presenting data; you’re presenting the process behind the creation of your data.

#4 Data Analysis and Results

Present your findings with precision and clarity. Utilise graphs, tables, and visuals to enhance comprehension. Peer review experts will closely examine your data analysis methods to ensure they are statistically sound. Transparency in reporting results, including any limitations or unexpected outcomes, is crucial. Remember, transparency fosters credibility.

Your data is the treasure you’ve unearthed through your research, and it’s time to present it with precision and clarity. Visual aids like graphs, tables, and visuals should be your artistic tools. Imagine yourself as a storyteller, weaving a narrative with data points.

data analytics software

Peer review experts will closely examine your data analysis methods to ensure they are statistically sound. It’s akin to having statisticians double-check your calculations. Transparency in reporting results is paramount. Think of it as being transparent about the ingredients of a recipe; it fosters credibility. Be honest about any limitations or unexpected outcomes, just as a chef might explain a dish’s unique flavours. Transparency invites trust and understanding.

#5 Discussion and Interpretation

This is your opportunity to showcase your critical thinking skills. Discuss the implications of your findings in the context of your thesis statement and existing literature. Address any unanswered questions or areas for future research. Peer review experts will assess the depth of your analysis and the coherence of your interpretations.

This is the moment when your audience gets a glimpse of your critical thinking skills. It’s not just about presenting data; it’s about the story behind the data. Consider yourself a detective solving a complex mystery. Discuss the implications of your findings in the context of your thesis statement and existing literature.

Address any unanswered questions or areas for future research. This is your chance to engage your audience in a scholarly conversation. Peer review experts will assess the depth of your analysis and the coherence of your interpretations. Think of it as a roundtable discussion where your ideas are put to the test.

#6 Effective Presentation Skills

Engage your audience with effective presentation skills. Practice your delivery, ensuring that you maintain eye contact, speak clearly, and use appropriate gestures. A confident and composed demeanour goes a long way in conveying your expertise. Utilise visual aids sparingly and strategically to enhance, not overwhelm, your presentation.

As you step into the spotlight of your thesis defence presentation, imagine yourself as a performer on the academic stage. Engage your audience with effective presentation skills that not only convey your expertise but also hold their attention. Practice your delivery meticulously to ensure that you maintain eye contact, speak clearly, and use appropriate gestures.

Confidence is your best companion on this stage. A confident and composed demeanour goes a long way in conveying your mastery of the subject matter. Utilise visual aids sparingly and strategically to enhance, not overwhelm, your presentation. Think of them as props in a play, designed to complement your narrative, not steal the show.

#7 Anticipate and Address Questions

Be prepared for a barrage of questions from the thesis committee during and after your presentation. Anticipate potential queries based on your research and be ready to provide well-informed responses. Peer review often extends to this phase, assessing your ability to defend your research and engage in scholarly discourse.

The Q&A session during and after your presentation is a challenging yet essential phase. Imagine it as the part of your performance where the audience gets to interact with you directly. Be prepared for a barrage of questions from the thesis committee. Anticipate potential queries based on your research and be ready to provide well-informed responses.

Peer review often extends to this phase, assessing your ability to defend your research and engage in scholarly discourse. Think of it as a debate where you defend your thesis against the toughest opponents. Embrace questions as opportunities to showcase your expertise and deepen the understanding of your work.

#8 Time Management

Respect the allocated time for your presentation. Going over your time limit can be detrimental and reflects poorly on your preparation. Time management is a skill that not only demonstrates professionalism but also allows for a smoother and more focused presentation.

Time management is the conductor’s baton in the symphony of your presentation. It’s not just about keeping things on schedule; it’s about ensuring that your performance is harmonious and well-paced. Respect the allocated time for your presentation. Going over your time limit can be detrimental and reflects poorly on your preparation.

Think of your presentation as a well-rehearsed orchestral piece, with each section seamlessly flowing into the next. Time management is the key to orchestrating this performance effectively. It demonstrates professionalism and allows for a smoother and more focused presentation.

successful thesis defence time management

#9 Adaptability

Be ready to adapt to unforeseen circumstances or questions. Your ability to handle unexpected challenges with grace and knowledge can leave a positive impression on both your thesis committee and peer reviewers.

In the world of academia, as in life, surprises are inevitable. Be ready to adapt to unforeseen circumstances or questions. Your ability to handle unexpected challenges with grace and knowledge can leave a lasting positive impression on both your thesis committee and peer reviewers.

Think of this adaptability as the mark of a seasoned explorer who can navigate uncharted territory. The ability to pivot gracefully when faced with the unexpected demonstrates your resilience and expertise.

#10 Mock Defences and Feedback

Prior to your actual defence, conduct mock thesis defence presentations with peers or mentors. Seek constructive feedback to refine your presentation. This rehearsal process can help you identify areas that may require improvement and boost your confidence.

Before the curtain rises on your actual defence, consider the value of dress rehearsals in the world of theatre. Prior to your defence, conduct mock thesis defence presentations with peers or mentors. Seek constructive feedback to refine your presentation. This rehearsal process can help you identify areas that may require improvement and boost your confidence.

Think of these mock defences as a preview performance, an opportunity to fine-tune your act before the main event. Constructive feedback from trusted sources is like the guidance of seasoned directors, helping you polish your performance and ensure you’re ready for the spotlight.

In conclusion, a successful thesis defence presentation is a multifaceted performance that combines research expertise, effective communication, and adaptability. Each component plays a crucial role in shaping the narrative of your research journey. Just as a skilled performer prepares meticulously for a show, you too must invest time and effort in honing your skills and refining your presentation. Embrace the peer review process as a means to elevate your work and ensure it stands up to the scrutiny of the academic community. With these key components and a commitment to excellence, you’ll not only defend your thesis but also make a meaningful contribution to your field of study.

Key Tips To A Successful Thesis Defence 

  • Clear and Concise Thesis Statement : Craft a thesis statement that is clear, concise, and aligned with your research.
  • Thorough Literature Review : Leave no stone unturned in your literature review to demonstrate your grasp of existing knowledge.
  • Prepare for Questions : Anticipate questions and practice your responses to showcase your expertise.
  • Practice and Timing : Practice your presentation and stick to the allotted time.
  • Adaptability and Confidence : Stay adaptable and confident in the face of unexpected challenges.

The Building Blocks of a Successful Thesis Defence Presentation

In the realm of academia, the successful thesis defence presentation is a culmination of years of dedication, research, and scholarship. It is a testament to your expertise in your chosen field and your ability to contribute to the body of knowledge. Key components, such as a well-defined thesis statement, a comprehensive literature review, meticulous data analysis, and effective presentation skills, are the building blocks of a successful presentation.

Moreover, the engagement with peer review processes adds a layer of scrutiny that enhances the quality and credibility of your work. Embrace feedback, both during mock defences and from the thesis committee, as opportunities for growth and refinement.

As you embark on this academic journey, remember that a successful thesis defence presentation is not just a milestone but a stepping stone to a future where your research can make a significant impact. The key to success lies in meticulous preparation, effective communication, and a deep passion for your subject matter. With these components in place, you are well on your way to a successful thesis defence.

Useful Resources

Way With Words – Website: https://waywithwords.net/services/transcription-services . A reliable source for academic research transcription services, ensuring accuracy and professionalism in transcribing your research data.

Peer Review Process – Website: https://www.elsevier.com/reviewers/what-is-peer-review . Understand the peer review process and its significance in academic research.

Engagement Questions

As you prepare for a successful thesis defence, ask yourself:

  • How can I best convey the significance of my research to both my thesis committee and the broader academic community?
  • How can I use peer review feedback to strengthen my work?
  • What are the key takeaways from my research that I want my audience to remember?

Remember that a successful thesis defence is not just about defending your research; it’s about sharing your passion and contributing to the academic discourse in your field. Embrace the journey, and you’ll emerge from it with a deeper understanding of your subject and a sense of accomplishment that comes from mastering this critical academic milestone.

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of ' ' (n): npl: theses
WordReference English-Italiano Dictionary © 2024:

IngleseItaliano
(unproven theory)tesi, teoria
 The philosopher sets out an interesting thesis in this book.
 Il filosofo esprime una teoria interessante nel suo libro.
(doctoral dissertation)tesi, tesi di dottorato
 The doctoral candidate took four years to write her thesis.
 La dottoranda ha impiegato quattro anni per scrivere la sua tesi.
(master's dissertation)tesi, tesi di laurea
 Alex has just submitted his thesis.
 Alex ha appena consegnato la sua tesi di laurea.
(theme for essay, discussion)argomento, tema
 The teacher wrote the thesis on the board and asked all the students to write an essay on it for the next class.
 L'insegnante scrisse l'argomento alla lavagna e chiese agli studenti di scriverci un tema per la prossima lezione.
 

WordReference English- Italiano Dictionary © 2024:


IngleseItaliano
(university: final-year dissertation)tesi di laurea
(dissertation: presentation of main argument)enunciato
([sb] writing doctoral dissertation)tesista

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17 Thesis Defense Questions and How to Answer Them

EditrixJD

A thesis defense gives you the chance to show off your thesis work and demonstrate your expertise in your field of study. During this one- to two-hour discussion with the members of your thesis committee, you'll have some control over how you present your research, but your committee will ask you some prodding questions to test your knowledge and preparedness. They will all have read your thesis beforehand, so their questions will relate to your study, topic, methods, data sample, and other aspects.

A good defense requires mastery of the thesis itself, so before you consider the questions you might face,

1. What is your topic, and why did you choose it?

Give a quick summary in just a few sentences on what you've researched. You could certainly go on for hours about your work, but make sure you prepare a way to give a very brief overview of your thesis. Then, give a quick background on your process for choosing this topic.

2. How does your topic contribute to the existing literature? How is it important?

Many researchers identify a need in the field and choose a topic to bridge the gaps that previous literature has failed to cover. For example, previous studies might not have included a certain population, region, or circumstance. Talk about how your thesis enhances the general understanding of the topic to extend the reach beyond what others have found, and then give examples of why the world needs that increased understanding. For instance, a thesis on romaine lettuce crops in desert climates might bring much-needed knowledge to a region that might not have been represented in previous work.

3. What are the key findings of your study?

When reporting your main results, make sure you have a handle on how detailed your committee wants you to be. Give yourself several options by preparing 1) a very general, quick summary of your findings that takes a minute or less, 2) a more detailed rundown of what your study revealed that is 3-5 minutes long, and 3) a 10- to 15-minute synopsis that delves into your results in detail. With each of these responses prepared, you can gauge which one is most appropriate in the moment, based on what your committee asks you and what has already been requested.

4. What type of background research did you do for your study?

Here you'll describe what you did while you were deciding what to study. This usually includes a literary review to determine what previous researchers have already introduced to the field. You also likely had to look into whether your study was going to be possible and what you would need in order to collect the needed data. Did you need info from databases that require permissions or fees?

5. What was your hypothesis, and how did you form it?

Describe the expected results you had for your study and whether your hypothesis came from previous research experience, long-held expectations, or cultural myths.

6. What limitations did you face when writing your text?

It's inevitable — researchers will face roadblocks or limiting factors during their work. This could be a limited population you had access to, like if you had a great method of surveying university students, but you didn't have a way to reach out to other people who weren't attending that school.

7. Why did you choose your particular method for your study?

Different research methods are more fitting to specific studies than others (e.g., qualitative vs. quantitative ), and knowing this, you applied a method that would present your findings most effectively. What factors led you to choose your method?

8. Who formed the sample group of your study, and why did you choose this population?

Many factors go into the selection of a participant group. Perhaps you were motivated to survey women over 50 who experience burnout in the workplace. Did you take extra measures to target this population? Or perhaps you found a sample group that responded more readily to your request for participation, and after hitting dead ends for months, convenience is what shaped your study population. Make sure to present your reasoning in an honest but favorable way.

9. What obstacles or limitations did you encounter while working with your sample?

Outline the process of pursuing respondents for your study and the difficulties you faced in collecting enough quality data for your thesis. Perhaps the decisions you made took shape based on the participants you ended up interviewing.

10. Was there something specific you were expecting to find during your analysis?

Expectations are natural when you set out to explore a topic, especially one you've been dancing around throughout your academic career. This question can refer to your hypotheses , but it can also touch on your personal feelings and expectations about this topic. What did you believe you would find when you dove deeper into the subject? Was that what you actually found, or were you surprised by your results?

11. What did you learn from your study?

Your response to this question can include not only the basic findings of your work (if you haven't covered this already) but also some personal surprises you might have found that veered away from your expectations. Sometimes these details are not included in the thesis, so these details can add some spice to your defense.

12. What are the recommendations from your study?

With connection to the reasons you chose the topic, your results can address the problems your work is solving. Give specifics on how policymakers, professionals in the field, etc., can improve their service with the knowledge your thesis provides.

13. If given the chance, what would you do differently?

Your response to this one can include the limitations you encountered or dead ends you hit that wasted time and funding. Try not to dwell too long on the annoyances of your study, and consider an area of curiosity; for example, discuss an area that piqued your interest during your exploration that would have been exciting to pursue but didn't directly benefit your outlined study.

14. How did you relate your study to the existing theories in the literature?

Your paper likely ties your ideas into those of other researchers, so this could be an easy one to answer. Point out how similar your work is to some and how it contrasts other works of research; both contribute greatly to the overall body of research.

15. What is the future scope of this study?

This one is pretty easy, since most theses include recommendations for future research within the text. That means you already have this one covered, and since you read over your thesis before your defense, it's already fresh in your mind.

16. What do you plan to do professionally after you complete your study?

This is a question directed more to you and your future professional plans. This might align with the research you performed, and if so, you can direct your question back to your research, maybe mentioning the personal motivations you have for pursuing study of that subject.

17. Do you have any questions?

Although your thesis defense feels like an interrogation, and you're the one in the spotlight, it provides an ideal opportunity to gather input from your committee, if you want it. Possible questions you could ask are: What were your impressions when reading my thesis? Do you believe I missed any important steps or details when conducting my work? Where do you see this work going in the future?

Bonus tip: What if you get asked a question to which you don't know the answer? You can spend weeks preparing to defend your thesis, but you might still be caught off guard when you don't know exactly what's coming. You can be ready for this situation by preparing a general strategy. It's okay to admit that your thesis doesn't offer the answers to everything – your committee won't reasonably expect it to do so. What you can do to sound (and feel!) confident and knowledgeable is to refer to a work of literature you have encountered in your research and draw on that work to give an answer. For example, you could respond, "My thesis doesn't directly address your question, but my study of Dr. Leifsen's work provided some interesting insights on that subject…." By preparing a way to address curveball questions, you can maintain your cool and create the impression that you truly are an expert in your field.

After you're done answering the questions your committee presents to you, they will either approve your thesis or suggest changes you should make to your paper. Regardless of the outcome, your confidence in addressing the questions presented to you will communicate to your thesis committee members that you know your stuff. Preparation can ease a lot of anxiety surrounding this event, so use these possible questions to make sure you can present your thesis feeling relaxed, prepared, and confident.

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Ph.D. Dissertation Defense: Anton Ratnarajah

ANNOUNCEMENT: Ph.D. Dissertation Defense

Name: Anton Ratnarajah

Professor Dinesh Manocha (Chair)

Professor Carol Espy-Wilson

Professor Ramani Duraiswami 

Professor Sanghamitra Dutta

Professor Nikhil Chopra, (Dean's Representative)

Date/Time: Friday,  August 23, 2024 at 1:00 to 3:00 p.m.

Location: AVW 1146 (ISR)

Sound propagation is the process through which sound energy emitted by a speaker travels through the air as sound waves. The room impulse response (RIR) describes this process and is influenced by the positions of the source and listener, the room's geometry, and its materials. Physics-based acoustic simulators have been used for decades to generate high-quality RIRs for specific acoustic environments. However, we have encountered limitations with existing acoustic simulators. For example, they require a 3D representation and detailed material knowledge of the environment. 

To address these limitations, we propose three solutions. First, we introduce a learning-based RIR generator that is two orders of magnitude faster than an interactive ray-tracing simulator. Our approach can be trained to be directly controlled using both statistical and traditional input parameters, and it can generate both monaural and binaural RIRs for both reconstructed and synthetic 3D scenes. Our generated RIRs outperform interactive ray-tracing simulators in speech-processing applications, including Automatic Speech Recognition (ASR), Speech Enhancement, and Speech Separation, by 2.5%, 12%, and 48%, respectively.

Secondly, we propose estimating RIRs from reverberant speech signals and visual cues in the absence of a 3D representation of the environment. By estimating RIRs from reverberant speech, we can augment training data to match test data, improving the word error rate of the ASR system. Our estimated RIRs achieve a 6.9% improvement over previous learning-based RIR estimators in real-world far-field ASR tasks. We also demonstrate that RIR estimation can be utilized for efficient compression of multi-channel audio codecs, significantly reducing the bandwidth of AudioDec by 52% for binaural speech. Our audio-visual RIR estimator aids tasks like visual acoustic matching, novel-view acoustic synthesis, and voice dubbing, validated through perceptual evaluation. 

Finally, we introduce IR-GAN to augment high-quality RIRs using real RIRs. IR-GAN parametrically controls acoustic parameters learned from real RIRs to generate new RIRs that imitate different acoustic environments, outperforming Ray-tracing simulators on the Kaldi far-field ASR benchmark by 8.95%.

Audience: Graduate   Faculty  

August 2024

SU MO TU WE TH FR SA

Purdue University Graduate School

Automated Exploration of Uncertain Deep Chemical Reaction Networks

Algorithmic reaction explorations based on transition state searches can now routinely predict relatively short reaction sequences involving small molecules across a variety of chemical domains, including materials degradation, combustion chemistry, battery performance, and biomass conversion. Mature quantum chemistry tools can comprehensively characterize the reactivity of species with efficiency and broad coverage, but consecutive characterizations quickly encounter prohibitive costs of reactant proliferation, spurious characterization of irrelevant intermediates, and compounding uncertainties of quantum chemical calculations deep in a network. Application of these algorithms to deeper chemical reaction network (CRN) exploration still requires the development of more effective, comprehensive, and automated exploration policies.

This dissertation addresses the challenge of exploring deep chemical reaction networks (CRNs) in complex and chemically diverse systems by introducing Yet Another Kinetic Strategy (YAKS), an automated algorithm designed to minimize the computational costs of deep exploration and maximize coverage of important reaction channels. YAKS demonstrates that microkinetic simulations of the nascent network are cost-effective and able to iteratively build deep networks. Key features of the algorithm are the automatic incorporation of expanded elementary reaction steps, compatibility with short-lived but kinetically important species, and the incorporation of rate uncertainty into the exploration policy. The automatically induced expansion of reaction mechanisms gives YAKS access to important chemistries that other algorithms ignore, while also maintaining the ability to limit expensive forays into kinetically irrelevant regions of the CRN that would stymie previous methods. Instead of conducting a greedy exploration, YAKS biases network topography to probe beyond short-lived but kinetically important species, which enables YAKS to explore important endergonic reactions deep into the CRN. YAKS further induces rate uncertainty into an ensemble of microkinetic simulations, which positively influences intermediate prioritization deep in a network.

Algorithm effectiveness was validated in a case study of glucose pyrolysis, where the algorithm rediscovers reaction pathways previously discovered by heuristic exploration policies and also elucidates new reaction pathways to experimentally obtained products. The resulting CRN is the first to connect all major experimental pyrolysis products to glucose. Additional case studies are presented that investigate the role of reaction rules, rate uncertainty, and bimolecular reactions. These case studies show that na\"ive exponential growth estimates can vastly overestimate the actual number of kinetically relevant pathways in physical reaction networks. The excellent performance of YAKS demonstrates the ability of automated algorithmic methods to address the gaps outlined above.

The power of YAKS was then demonstrated on radically distinct chemistry from the validation study, chemical warfare agents (CWAs). Despite the almost uniform ban on the use of chemical agents and the widespread neutralization of stockpiles due to treaties, CWAs continue to pose a grave threat around the world. Rogue states, terrorist organizations, and lone wolf terrorists have all conducted CWA attacks within the past few decades. These circumstances make it necessary to prepare against and forensically evaluate the use of CWAs without direct experimentation. YAKS was applied to elucidate degradation reaction networks of three prominent CWAs, mustard gas (SM, HD), sarin (GB), and VX, and identified a range of possible degradant products of real world use cases. This dissertation also computationally interpreted the most common mechanism of action (MoA) associated with each CWA and examined their hydrolysis networks as a method to neutralize these agents. Additionally, agent stability was evaluated during extended microkinetic modeling in arid and humid scenarios, highlighting the potential for computational simulation approaches to fill a capability gap in the broader field of chemical defense.

This dissertation advanced automated CRN exploration, but considerable gaps remain. Future research directions include the accuracy gaps of both density functional theory and conformational sampling on energy calculations. Incorporation of machine learning (ML) methods can accelerate the costly reactivity characterization process, but ML models still require vast amounts of data. A recently released dataset comprehensively explored over 175,000 graphically defined reactions of moderately-sized C, H, O, and N containing molecules. While models trained on such data could readily be applied to glucose pyrolysis systems, chemical agents involve a much wider array of chemistry including Cl, S, P, and considerable quantities of radical and charged species. More comprehensive datasets are required to train a general ML model capable of accelerating geometry or energy calculations. Additionally, microkinetic modeling is hindered by software implementations that are unable to explore diverse chemistry such as multiphase reactions. In light of this, further improvements in exploration policies, reaction prediction algorithms, and simulation software make it feasible that CRNs might soon be routinely predictable in many additional contexts.

Degree Type

  • Doctor of Philosophy
  • Chemical Engineering

Campus location

  • West Lafayette

Advisor/Supervisor/Committee Chair

Additional committee member 2, additional committee member 3, additional committee member 4, usage metrics.

  • Chemical engineering not elsewhere classified

CC BY 4.0

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  25. Automated Exploration of Uncertain Deep Chemical Reaction Networks

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