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Bacteriophages had been a subject of experimental investigation since Félix d'Herelle had isolated and developed methods for detecting and culturing them, beginning in 1917. Delbrück, a physicist-turned biologist seeking the simplest possible experimental system to probe the fundamental laws of life, first encountered phages during a 1937 visit to T. H. Morgan's fly lab at Caltech. Delbrück was unimpressed with Morgan's experimentally complex model organism Drosophila, but anothe…
First performed by Ellis and Delbruck in 1939, this classic experiment illustrates the true nature of virus replication. Details of the experiment are given in the text. Two bursts …
Ellis and Delbruck 1939 - Single burst experiment Method 1. Bacteriophage particles added to culture of rapidly growing bacteria 2.
The Luria–Delbrück experiment (1943) (also called the Fluctuation Test) demonstrated that in bacteria, genetic mutations arise in the absence of selective pressure rather than being a response to it. Thus, it concluded Darwin's theory of natural selection acting on random mutations applies to bacteria as well as to more complex organisms. Max Delbrück and Salvador Luria won the 1969 Nobel Prize in Physiology or Medicine
One of the seminal experiments in the history of genetics owes part of its inspiration to the presence of slot machines at a faculty mixer at the University of Indiana in 1942 (Luria and …
1. An anti-Escherichia coli phage has been isolated and its behavior studied. 2. A plaque counting method for this phage is described, and shown to give a number of plaques which is …