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45 Cool Chemistry Experiments, Demos, and Science Fair Projects

Don’t forget your safety equipment!

Bunsen burners, colorful chemicals, and the possibility of a (controlled) explosion or two? Everybody loves chemistry experiments! We’ve rounded up the best activities, demos, and chemistry science fair projects for kids and teens. Try them in the classroom or at home.

Easy Chemistry Experiments and Activities for All Ages

Chemistry science fair projects.

These chemistry experiments and activities are all easy to do using simple supplies you probably already have. Families can try them at home, or teachers and students can do them together in the classroom.

Mix up some magic milk

Kids love this colorful experiment, which explores the concept of surface tension. This is one of our favorite chemistry experiments to try at home, since the supplies are so basic and the results are so cool!

Taste the Rainbow

Teach your students about diffusion while creating a beautiful and tasty rainbow. You’ll definitely want to have extra Skittles on hand so your class can enjoy a few as well!

Learn more: Skittles Diffusion

Crystallize sweet treats

Crystal science experiments teach kids about supersaturated solutions. This one is easy to do at home, and the results are absolutely delicious!

Learn more: Candy Crystals

Make elephant-sized toothpaste

This fun project uses yeast and a hydrogen peroxide solution to create overflowing “elephant toothpaste.” You can also add an extra fun layer by having kids create toothpaste wrappers for their plastic bottles.

Blow the biggest bubbles you can

Add a few simple ingredients to dish soap solution to create the largest bubbles you’ve ever seen! Kids learn about surface tension as they engineer these bubble-blowing wands.

Learn more: Giant Soap Bubbles

Demonstrate the “magic” leakproof bag

So simple and so amazing! All you need is a zip-top plastic bag, sharp pencils, and some water to blow your kids’ minds. Once they’re suitably impressed, teach them how the “trick” works by explaining the chemistry of polymers.

Learn more: Leakproof Bag

Use apple slices to learn about oxidation

Have students make predictions about what will happen to apple slices when immersed in different liquids, then put those predictions to the test! Finally, have them record their observations.

Learn more: Apple Oxidation

Float a marker man

Their eyes will pop out of their heads when you “levitate” a stick figure right off the table. This experiment works due to the insolubility of dry-erase marker ink in water, combined with the lighter density of the ink.

Learn more: Floating Marker Man

Discover density with hot and cold water

There are a lot of easy science experiments you can do with density. This one is extremely simple, involving only hot and cold water and food coloring, but the visuals make it appealing and fun.

Learn more: Layered Water

Layer more liquids

This density demo is a little more complicated, but the effects are spectacular. Slowly layer liquids like honey, dish soap, water, and rubbing alcohol in a glass. Kids will be amazed when the liquids float one on top of the other like magic (except it is really science).

Learn more: Layered Liquids

Grow a carbon sugar snake

Easy science experiments can still have impressive results. This eye-popping chemical reaction demonstration only requires simple supplies like sugar, baking soda, and sand.

Learn more: Carbon Sugar Snake

Make homemade bouncy balls

These homemade bouncy balls are easy to make since all you need is glue, food coloring, borax powder, cornstarch, and warm water. You’ll want to store them inside a container like a plastic egg because they will flatten out over time.

Learn more: Make Your Own Bouncy Balls

Create eggshell chalk

Eggshells contain calcium, the same material that makes chalk. Grind them up and mix them with flour, water, and food coloring to make your very own sidewalk chalk.

Learn more: Eggshell Chalk

Make naked eggs

This is so cool! Use vinegar to dissolve the calcium carbonate in an eggshell to discover the membrane underneath that holds the egg together. Then, use the “naked” egg for another easy science experiment that demonstrates osmosis .

Learn more: Naked Egg Experiment

Turn milk into plastic

This sounds a lot more complicated than it is, but don’t be afraid to give it a try. Use simple kitchen supplies to create plastic polymers from plain old milk. Sculpt them into cool shapes when you’re done.

Test pH using cabbage

Teach kids about acids and bases without needing pH test strips. Simply boil some red cabbage and use the resulting water to test various substances—acids turn red and bases turn green.

Learn more: Cabbage pH

Clean some old coins

Use common household items to make old oxidized coins clean and shiny again in this simple chemistry experiment. Ask kids to predict (hypothesize) which will work best, then expand the learning by doing some research to explain the results.

Learn more: Cleaning Coins

Blow up a balloon (without blowing)

Chances are good you probably did easy science experiments like this when you were in school yourself. This well-known activity demonstrates the reactions between acids and bases. Fill a bottle with vinegar and a balloon with baking soda. Fit the balloon over the top, shake the baking soda down into the vinegar, and watch the balloon inflate.

Learn more: Balloon Experiments

Assemble a DIY lava lamp

This 1970s trend is back—as an easy science experiment! This activity combines acid/base reactions with density for a totally groovy result.

Explore how sugary drinks affect teeth

The calcium content of eggshells makes them a great stand-in for teeth. Use eggs to explore how soda and juice can stain teeth and wear down the enamel. Expand your learning by trying different toothpaste and toothbrush combinations to see how effective they are.

Learn more: Sugar and Teeth Experiment

Mummify a hot dog

If your kids are fascinated by the Egyptians, they’ll love learning to mummify a hot dog. No need for canopic jars ; just grab some baking soda and get started.

Extinguish flames with carbon dioxide

This is a fiery twist on acid-base experiments. Light a candle and talk about what fire needs in order to survive. Then, create an acid-base reaction and “pour” the carbon dioxide to extinguish the flame. The CO2 gas acts like a liquid, suffocating the fire.

Send secret messages with invisible ink

Turn your kids into secret agents! Write messages with a paintbrush dipped in lemon juice, then hold the paper over a heat source and watch the invisible become visible as oxidation goes to work.

Learn more: Invisible Ink

Set popcorn dancing

This is a fun version of the classic baking soda and vinegar experiment, perfect for the younger crowd. The bubbly mixture causes popcorn to dance around in the water.

Learn more: Dancing Popcorn Experiment

Shoot a soda geyser sky-high

You’ve always wondered if this really works, so it’s time to find out for yourself! Kids will marvel at the chemical reaction that sends diet soda shooting high in the air when Mentos are added.

Learn more: Mentos and Coke Experiment

All of these chemistry experiments are perfect for using the scientific method. Form a hypothesis, alter the variables, and then observe the results! You can simplify these projects for younger kids, or add more complexity for older students.

Break apart covalent bonds

Difficulty: Medium / Materials: Medium

Break the covalent bond of H 2 O into H and O with this simple experiment. You only need simple supplies for this one. Turn it into a science fair project by changing up the variables—does the temperature of the water matter? What happens if you try this with other liquids?

Learn more: Breaking Covalent Bonds

Measure the calories in various foods

Are the calorie counts on your favorite snacks accurate? Build your own calorimeter and find out! This kit from Home Science Tools has all the supplies you’ll need.

Detect latent fingerprints

Forensic science is engrossing and can lead to important career opportunities too. Explore the chemistry needed to detect latent (invisible) fingerprints, just like they do for crime scenes!

Learn more: Fingerprints Project

Use Alka-Seltzer to explore reaction rate

Difficulty: Easy / Materials: Easy

Tweak this basic concept to create a variety of high school chemistry science fair projects. Change the temperature, surface area, pressure, and more to see how reaction rates change.

Determine whether sports drinks really have more electrolytes than other beverages

Difficulty: Medium / Materials: Advanced

Are those pricey sports drinks really worth it? Try this experiment to find out. You’ll need some special equipment for this one; buy a complete kit at Home Science Tools .

Turn flames into a rainbow

You’ll need to get your hands on a few different chemicals for this experiment, but the wow factor will make it worth the effort. Make it a science project by seeing if different materials, air temperature, or other factors change the results.

Discover the size of a mole

The mole is a key concept in chemistry, so it’s important to ensure students really understand it. This experiment uses simple materials like salt and chalk to make an abstract concept more concrete. Make it a project by applying the same procedure to a variety of substances, or determining whether outside variables have an effect on the results.

Learn more: How Big Is a Mole?

Cook up candy to learn mole and molecule calculations

This edible experiment lets students make their own peppermint hard candy while they calculate mass, moles, molecules, and formula weights. Tweak the formulas to create different types of candy and make this into a sweet science fair project!

Learn more: Candy Chemistry

Make soap to understand saponification

Take a closer look at an everyday item: soap! Use oils and other ingredients to make your own soap, learning about esters and saponification. Tinker with the formula to find one that fits a particular set of parameters.

Learn more: Saponification

Uncover the secrets of evaporation

Explore the factors that affect evaporation, then come up with ways to slow them down or speed them up for a simple science fair project.

Learn more: Evaporation

More Chemistry Experiment Science Fair Ideas

These questions and prompts can spark ideas for unique chemistry experiments:

• Compare the properties of sugar and artificial sweeteners.
• Explore the impact of temperature, concentration, and seeding on crystal growth.
• Test various antacids on the market to find the most effective product.
• What is the optimum temperature for yeast production when baking bread from scratch?
• Compare the vitamin C content of various fruits and vegetables.
• How does temperature affect enzyme-catalyzed reactions?
• Investigate the effects of pH on an acid-base chemical reaction.
• Devise a new natural way to test pH levels (such as cabbage leaves).
• What’s the best way to slow down metal oxidation (the form of rust)?
• How do changes in ingredients and method affect the results of a baking recipe?

Like these chemistry experiments? Don’t miss STEM Activities for Kids of All Ages and Interests .

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68 Best Chemistry Experiments: Learn About Chemical Reactions

Whether you’re a student eager to explore the wonders of chemical reactions or a teacher seeking to inspire and engage your students, we’ve compiled a curated list of the top 68 chemistry experiments so you can learn about chemical reactions.

While the theories and laws governing chemistry can sometimes feel abstract, experiments bridge the gap between these concepts and their tangible manifestations. These experiments provide hands-on experiences illuminating the intricacies of chemical reactions, molecular structures, and elemental properties.

1. Covalent Bonds

By engaging in activities that demonstrate the formation and properties of covalent bonds, students can grasp the significance of these bonds in holding atoms together and shaping the world around us.

Learn more: Covalent Bonds

2. Sulfuric Acid and Sugar Demonstration

Through this experiment, students can develop a deeper understanding of chemical properties, appreciate the power of chemical reactions, and ignite their passion for scientific exploration.

3. Make Hot Ice at Home

Making hot ice at home is a fascinating chemistry experiment that allows students to witness the captivating transformation of a liquid into a solid with a surprising twist.

4. Make a Bouncing Polymer Ball

This hands-on activity not only allows students to explore the fascinating properties of polymers but also encourages experimentation and creativity.

Learn more: Thought Co

5. Diffusion Watercolor Art

This experiment offers a wonderful opportunity for students to explore the properties of pigments, observe how they interact with water, and discover the mesmerizing patterns and textures that emerge.

Learn more: Diffusion Watercolor Art

6. Exploding Baggie

The exploding baggie experiment is a captivating and dynamic demonstration that students should engage in with caution and under the supervision of a qualified instructor.

Learn more: Exploding Baggie

7. Color Changing Chemistry Clock

This experiment not only engages students in the world of chemical kinetics but also introduces them to the concept of a chemical clock, where the color change acts as a timekeeping mechanism.

Learn more: Color Changing Chemistry Clock

8. Pipe Cleaner Crystal Trees

By adjusting the concentration of the Borax solution or experimenting with different pipe cleaner arrangements, students can customize their crystal trees and observe how it affects the growth patterns.

Learn more: Pipe Cleaner Crystal Trees

9. How To Make Ice Sculptures

Through this experiment, students gain a deeper understanding of the physical and chemical changes that occur when water freezes and melts.

Learn more: Ice Sculpture

10. How to Make Paper

Through this hands-on activity, students gain a deeper understanding of the properties of cellulose fibers and the transformative power of chemical reactions.

Learn more: How to Make Paper

11. Color Changing Chemistry

Color changing chemistry is an enchanting experiment that offers a captivating blend of science and art. Students should embark on this colorful journey to witness the mesmerizing transformations of chemicals and explore the principles of chemical reactions.

12. Gassy Banana

The gassy banana experiment is a fun and interactive way for students to explore the principles of chemical reactions and gas production.

Learn more: Gassy Banana

13. Gingerbread Man Chemistry Experiment

This hands-on activity not only introduces students to the concepts of chemical leavening and heat-induced reactions but also allows for creativity in decorating and personalizing their gingerbread creations.

Learn more: Gingerbread Man Chemistry Experiment

14. Make Amortentia Potion

While the love potion is fictional, this activity offers a chance to explore the art of potion-making and the chemistry behind it.

Learn more: How to Make Amortentia Potion

15. Strawberry DNA Extraction

This hands-on experiment offers a unique opportunity to observe DNA, the building blocks of life, up close and learn about its structure and properties.

16. Melting Snowman

The melting snowman experiment is a fun and whimsical activity that allows students to explore the principles of heat transfer and phase changes.

Learn more: Melting Snowman

17. Acid Base Cabbage Juice

The acid-base cabbage juice experiment is an engaging and colorful activity that allows students to explore the pH scale and the properties of acids and bases.

By extracting the purple pigment from red cabbage leaves and creating cabbage juice, students can use this natural indicator to identify and differentiate between acidic and basic substances.

Learn more: Acid Base Cabbage Juice

18. Magic Milk

The magic milk experiment is a mesmerizing and educational activity that allows students to explore the concepts of surface tension and chemical reactions.

By adding drops of different food colors to a dish of milk and then introducing a small amount of dish soap, students can witness a captivating display of swirling colors and patterns.

Learn more: Magic Milk

19. Melting Ice with Salt and Water

Through this hands-on activity, students can gain a deeper understanding of the science behind de-icing and how different substances can influence the physical properties of water.

Learn more: Melting Ice with Salt and Water

20. Barking Dog Chemistry Demonstration

The barking dog chemistry demonstration is an exciting and visually captivating experiment that showcases the principles of combustion and gas production.

21. How to Make Egg Geodes

Making egg geodes is a fascinating and creative chemistry experiment that students should try. By using common materials like eggshells, salt, and food coloring, students can create their own beautiful geode-like crystals.

Learn more: How to Make Egg Geodes

22. Make Sherbet

This experiment not only engages the taste buds but also introduces concepts of acidity, solubility, and the chemical reactions that occur when the sherbet comes into contact with moisture.

Learn more: Make Sherbet

23. Hatch a Baking Soda Dinosaur Egg

As the baking soda dries and hardens around the toy, it forms a “shell” resembling a dinosaur egg. To hatch the egg, students can pour vinegar onto the shell, causing a chemical reaction that produces carbon dioxide gas.

Learn more: Steam Powered Family

24. Chromatography Flowers

By analyzing the resulting patterns, students can gain insights into the different pigments present in flowers and the science behind their colors.

Learn more: Chromatography Flowers

25. Turn Juice Into Solid

Turning juice into a solid through gelification is an engaging and educational chemistry experiment that students should try. By exploring the transformation of a liquid into a solid, students can gain insights of chemical reactions and molecular interactions.

Learn more: Turn Juice into Solid

26. Bouncy Balls

Making bouncy balls allows students to explore the fascinating properties of polymers, such as their ability to stretch and rebound.

 27. Make a Lemon Battery

Creating a lemon battery is a captivating and hands-on experiment that allows students to explore the fundamentals of electricity and chemical reactions.

28. Mentos and Soda Project

The Mentos and soda project is a thrilling and explosive experiment that students should try. By dropping Mentos candies into a bottle of carbonated soda, an exciting eruption occurs.

29. Alkali Metal in Water

The reaction of alkali metals with water is a fascinating and visually captivating chemistry demonstration.

30. Rainbow Flame

The rainbow flame experiment is a captivating and visually stunning chemistry demonstration that students should explore.

31. Sugar Yeast Experiment

This experiment not only introduces students to the concept of fermentation but also allows them to witness the effects of a living organism, yeast, on the sugar substrate.

32. The Thermite Reaction

The thermite reaction is a highly energetic and visually striking chemical reaction that students can explore with caution and under proper supervision.

This experiment showcases the principles of exothermic reactions, oxidation-reduction, and the high temperatures that can be achieved through chemical reactions.

33. Polishing Pennies

Polishing pennies is a simple and enjoyable chemistry experiment that allows students to explore the concepts of oxidation and cleaning methods.

34. Elephant Toothpaste

The elephant toothpaste experiment is a thrilling and visually captivating chemistry demonstration that students should try with caution and under the guidance of a knowledgeable instructor.

35. Magic Potion

Creating a magic potion is an exciting and imaginative activity that allows students to explore their creativity while learning about the principles of chemistry.

36. Color Changing Acid-Base Experiment

Through the color changing acid-base experiment, students can gain a deeper understanding of chemical reactions and the role of pH in our daily lives.

Learn more: Color Changing Acid-Base Experiment

37. Fill up a Balloon

Filling up a balloon is a simple and enjoyable physics experiment that demonstrates the properties of air pressure. By blowing air into a balloon, you can observe how the balloon expands and becomes inflated.

38. Jello and Vinegar

The combination of Jello and vinegar is a fascinating and tasty chemistry experiment that demonstrates the effects of acid on a gelatin-based substance.

Learn more: Jello and Vinegar

39. Vinegar and Steel Wool Reaction

This experiment not only provides a visual demonstration of the oxidation process but also introduces students to the concept of corrosion and the role of acids in accelerating the process.

Learn more: Vinegar and Steel Wool Reaction

40. Dancing Rice

The dancing rice experiment is a captivating and educational demonstration that showcases the principles of density and buoyancy.

By pouring a small amount of uncooked rice into a clear container filled with water, students can witness the rice grains moving and “dancing” in the water.

Learn more: Dancing Rice

41. Soil Testing Garden Science

Soil testing is a valuable and informative experiment that allows students to assess the composition and properties of soil.

By collecting soil samples from different locations and analyzing them, students can gain insights into the nutrient content, pH level, and texture of the soil.

Learn more: Soil Testing Garden Science

42. Heat Sensitive Color Changing Slime

Creating heat-sensitive color-changing slime is a captivating and playful chemistry experiment that students should try.

Learn more: Left Brain Craft Brain

43. Experimenting with Viscosity

Experimenting with viscosity is an engaging and hands-on activity that allows students to explore the flow properties of liquids.

Viscosity refers to a liquid’s resistance to flow, and this experiment enables students to investigate how different factors affect viscosity.

Learn more: Experimenting with Viscosity

44. Rock Candy Science

Rock candy science is a delightful and educational chemistry experiment that students should try. By growing their own rock candy crystals, students can learn about crystal formation and explore the principles of solubility and saturation.

Learn more: Rock Candy Science

45. Baking Soda vs Baking Powder

Baking soda and baking powder have distinct properties that influence the leavening process in different ways.

This hands-on experiment provides a practical understanding of how these ingredients interact with acids and moisture to create carbon dioxide gas.

46. Endothermic and Exothermic Reactions Experiment

The endothermic and exothermic reactions experiment is an exciting and informative chemistry exploration that students should try.

By observing and comparing the heat changes in different reactions, students can gain a deeper understanding of energy transfer and the concepts of endothermic and exothermic processes.

Learn more: Education.com

47. Diaper Chemistry

By dissecting a diaper and examining its components, students can uncover the chemical processes that make diapers so effective at absorbing and retaining liquids.

Learn more: Diaper Chemistry

48. Candle Chemical Reaction

The “Flame out” experiment is an intriguing and educational chemistry demonstration that students should try. By exploring the effects of a chemical reaction on a burning candle, students can witness the captivating moment when the flame is extinguished.

49. Make Curds and Whey

This experiment not only introduces students to the concept of acid-base reactions but also offers an opportunity to explore the science behind cheese-making.

Learn more: Tinkerlab

50. Grow Crystals Overnight

By creating a supersaturated solution using substances like epsom salt, sugar, or borax, students can observe the fascinating process of crystal growth. This experiment allows students to explore the principles of solubility, saturation, and nucleation.

Learn more: Grow Crystals Overnight

51. Measure Electrolytes in Sports Drinks

The “Measure Electrolytes in Sports Drinks” experiment is an informative and practical chemistry activity that students should try.

By using simple tools like a multimeter or conductivity probe, students can measure the electrical conductivity of different sports drinks to determine their electrolyte content.

52. Oxygen and Fire Experiment

The oxygen and fire experiment is a captivating and educational chemistry demonstration that students should try. By observing the effects of oxygen on a controlled fire, students can witness the essential role of oxygen in supporting combustion.

53. Electrolysis Of Water

The electrolysis of water experiment is a captivating and educational chemistry demonstration that students should try.

Learn more: Electrolysis Of Water

54. Expanding Ivory Soap

The expanding Ivory Soap experiment is a fun and interactive chemistry activity that students should try. By placing a bar of Ivory soap in a microwave, students can witness the remarkable expansion of the soap as it heats up.

Learn more: Little Bins Little Hands

55. Glowing Fireworks

This experiment not only introduces students to the principles of pyrotechnics and combustion but also encourages observation, critical thinking, and an appreciation for the physics and chemistry behind.

Learn more: Glowing Fireworks

56. Colorful Polymer Chemistry

Colorful polymer chemistry is an exciting and vibrant experiment that students should try to explore polymers and colorants.

By combining different types of polymers with various colorants, such as food coloring or pigments, students can create a kaleidoscope of colors in their polymer creations.

Learn more: Colorful Polymer Chemistry

57. Sulfur Hexafluoride- Deep Voice Gas

This experiment provides a firsthand experience of how the density and composition of gases can influence sound transmission.

It encourages scientific curiosity, observation, and a sense of wonder as students witness the surprising transformation of their voices.

58. Liquid Nitrogen Ice Cream

Liquid nitrogen ice cream is a thrilling and delicious chemistry experiment that students should try. By combining cream, sugar, and flavorings with liquid nitrogen, students can create ice cream with a unique and creamy texture.

59. White Smoke Chemistry Demonstration

The White Smoke Chemistry Demonstration provides an engaging and visually captivating experience for students to explore chemical reactions and gases. By combining hydrochloric acid and ammonia solutions, students can witness the mesmerizing formation of white smoke.

60. Nitrogen Triiodide Chemistry Demonstration

The nitrogen triiodide chemistry demonstration is a remarkable and attention-grabbing experiment that students should try under the guidance of a knowledgeable instructor.

By reacting iodine crystals with concentrated ammonia, students can precipitate nitrogen triiodide (NI3), a highly sensitive compound.

61. Make a Plastic- Milk And Vinegar Reaction Experiment

Through the “Make a Plastic – Milk and Vinegar Reaction” experiment, students can gain a deeper understanding of the chemistry behind plastics, environmental sustainability, and the potential of biodegradable materials.

Learn more: Rookie Parenting

62. Eno and Water Experiment

This experiment not only introduces students to acid-base reactions but also engages their senses as they witness the visible and audible effects of the reaction.

63. The Eternal Kettle Experiment

By filling a kettle with alcohol and igniting it, students can investigate the behavior of the alcohol flame and its sustainability.

64. Coke and Chlorine Bombs

Engaging in this experiment allows students to experience the wonders of chemistry firsthand, making it an ideal choice to ignite their curiosity and passion for scientific exploration.

65. Set your Hand on Fire

This experiment showcases the fascinating nature of combustion and the science behind fire.

By carefully following proper procedures and safety guidelines, students can witness firsthand how the sanitizer’s high alcohol content interacts with an open flame, resulting in a brief but captivating display of controlled combustion.

66. Instant Ice Experiments

The Instant Ice Experiment offers an engaging and captivating opportunity for students to explore the wonders of chemistry and phase changes.

By using simple household ingredients, students can witness the fascinating phenomenon of rapid ice formation in just a matter of seconds.

67. Coke Cans in Acid and Base

Engaging in this experiment allows students to gain a deeper understanding of the chemical properties of substances and the importance of safety protocols in scientific investigations.

68. Color Changing Invisible Ink

The Color Changing Invisible Ink experiment offers an intriguing and fun opportunity for students to explore chemistry and learn about the concept of chemical reactions.

Learn more: Research Parent

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Expertly communicate the excitement of chemistry with these time-tested classroom practicals.

These resources have been compiled from the book Classic chemistry experiments : a collection of 100 chemistry experiments developed with the support of teachers throughout the UK.

If you'd like to buy a copy of the book, visit our online bookshop . If you're a Royal Society of Chemistry member, don't forget to use your 35% discount.

A Cartesian diver

An old favourite experiment, the Cartesian diver is easy for students to complete. Explore important ideas that build a foundation of knowledge. 

Chemistry and electricity

Create coloured writing from acids, alkali, and salt solution, all activated through electrolysis.

Disappearing ink

Explore the reaction between acids and bases as students create disappearing ink, in this favourite classroom practical.

Electricity from chemicals

Use various metals, in pairs, and n electrolyte to form a cell. Then observe the formation of ions around the reactive metal, and compare the speed with which they form around the less reactive metal. Includes kit list and safety instructions. 

Experiments with particles

Explore physical states, and how material interact with three practicals. Students use common classroom items to explore, and then note their findings. Includes kit list and safety instructions. 

Identifying the products of combustion

In association with Nuffield Foundation

Illustrate the presence of water and carbon dioxide in the products of hydrocarbon combustion in this demonstration. Includes kit list and safety instructions.

Particles in motion?

Explore the movement of gas particles in this practical but reacting calcium carbonate with hydrochloric acid. Includes kit list and safety instructions. 

Producing a foam

Explore foams and their properties in this experiment, so students learn how foam is produced and produce their own. Includes kit list and safety instructions.

Properties of the transition metals and their compounds

Student discover the diversity of transition metals in this practical that puts their knowledge of these common elements to the test. Includes kit list and safety instructions.

Rubber band experiment

A rubber band, a hairdryer, and a curious mind will see students discover the principles of heat based reactions. Includes kit list and safety instruction.

Testing salts for anions and cations

A full range of chemicals will guide students into discovering how to identify the composition of unknown substances. Includes kit list and safry instructions. 

The effect of concentration and temperature on reaction rate

Reaction rate can be altered by many things, in this practical students explore how temperature and concentration effect reaction in an closer look at kinetics. Includes kit list and safety instructions. 

The effect of temperature on reaction rate

Discover more about collision theory in this practical, where a sodium thiosulfate and hydrochloric acid mixture produce an interesting reaction. Includes kit list and safety instructions. 

The effect of temperature on solubility

Hot or cold, which water is better for soluble substances? Explore your finding from this practical into the effect of temperature on solubility. Includes kit list and safety instructions. 

The electrolysis of solutions

Electricity is passed through various solutions and the products are identified. Includes kit list and safety instructions

The preparation and properties of oxygen

Produce a potassium manganate(VII) reaction using a test tube, Bunsen burner, and scientific inquisition to detect the presence of oxygen. Includes kit list and safety instructions.

The reactivity of the group 2 metals

Compare group 1 and group 2 metals with this practical that shows their reactivity rates, where students can take control of their own observations and come to their own conclusions

The volume of 1 mole of hydrogen gas

Understand the volume of one mole of hydrogen gas through a magnesium and acid reaction, taking note of the temperature and pressure. Includes kit list and safety instructions. 

Compare the viscosity of thick and thin liquids in this experiment, which gets young learners exploring how viscosity alters the speed of an air bubble through the substances. Includes kit list and safety instructions.

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65 Amazing Chemistry Experiments for Kids

Chemistry is so much fun, and we have tons of cool chemistry experiments to share with you. Like our awesome physics experiments , we decided we needed to put together a list of fun chemistry projects kids can do at home or in the classroom. Check out these examples of easy chemical reactions below!

65 Chemistry Experiments You Want To Try

We have divided our chemistry experiments below into chemical reactions, acids and bases, chromatography, solutions, polymers, and crystals. Some chemistry experiments also explore concepts in physics .

Chemical Reactions

A chemical reaction is a process where two or more substances react together to form a new chemical substance. This might look like a gas formed, cooking or baking, milk souring, etc.

Sometimes a physical change occurs, like our popcorn experiment or melting crayons, rather than a chemical change . However, these experiments below are all great examples of chemical change, where a new substance is formed.

CHECK OUT: Examples Of Physical Change and Chemical Change Examples

Can chemical reactions happen safely at home or in the classroom? Absolutely! This is one of the most fun parts of chemistry for kids, and you will find lots of ideas below for safe chemical reactions you can do with your junior scientists.

Acids And Bases

Acids and bases are important for many chemical processes in everyday life. An acid has hydrogen ions and can donate protons. Acids taste sour and have a pH from 0 to 7. Vinegar and citric acid are examples of acids.

Bases are molecules that can accept hydrogen ions. They have a pH higher than seven and can taste bitter. Sodium bicarbonate or baking soda and ammonia are examples of bases. Learn more about the pH scale.

Vinegar and baking soda experiments are classic acid-base reactions. You’ll also find experiments that use an acid such as vinegar or lemon juice. We have so many fun variations that your kids will love to try! Check out these acid-base chemistry experiments below.

Chromatography

Chromatography is a technique that involves the separation of a mixture into its parts so you can see each one individually.

A solution is a mixture of 2 or more solutes dissolved in a solvent up to its solubility limit. It most often refers to liquids, but solutions, gases, and solids are also possible. A solution will have its components evenly distributed throughout the mixture.

Chemistry experiments involving solutions are great for kids. Gather liquids you commonly find in your kitchen, oil, water, detergent, etc., and explore what dissolves.

A polymer is a huge molecule made of many smaller molecules layered together in repeating patterns called monomers. Putty, slime, and cornstarch are all examples of polymers. Learn more about the science of slime polymers .

Making slime is great for at-home chemistry! It’s also a classic middle school science demonstration for the classroom. Here are a few of our favorite slime recipes to get you started.

non-Newtonian Fluids

Learn how to make oobleck ! Explore polymers with a simple cornstarch and water mixture.

A crystal is a solid material with a highly ordered internal structure of atoms, molecules, or ions held together by chemical bonds. Grow crystals and observe them by mixing a super-saturated solution and leaving it for several days to let the crystals form.

Simple to grow and taste-safe, a sugar crystals experiment is more accessible for younger kids, but you can also try growing borax crystals for older kids.

Check out our fun theme variations of growing crystals too!

Chemistry For Preschoolers

Let’s keep it basic for our younger or junior scientists! Chemistry is all about how different materials are put together and what they are made up of, like atoms and molecules.

What can you do with your youngest scientists? While working 1-1 or in a very small group is ideal, you can explore chemistry in a few fun ways that don’t require a lengthy setup or a lot of directions to follow. Do NOT overcomplicate the ideas!

Take, for example, our very first baking soda science experiment (age 3). So simple to set up, but so lovely to watch the amazement on my son’s face.

Check out these fun ways for preschoolers to explore science…

• Make liquid mixtures! Mix water and oil in a jar, let it rest, and observe what happens.
• Make solid mixtures! Mix two solid items and observe the changes!
• Mix a solid and a liquid! Add ice to a drink and observe the changes!
• Make a reaction! Set up a tray with baking soda in small cups and colored vinegar in small cups with pipettes. Mix and observe!
• Make oobleck ! Mix cornstarch and water for a weird and messy science activity.
• Explore characteristics of things! Use new science words to describe how different materials feel. Explore squishy, hard, rough, smooth, wet, etc…

Much of preschool science is about you sharing new experiences with them that are relatable and simple. A sk questions, share new words, and offer verbal prompts to get them to communicate with you about what they see!

Chemistry Science Fair Projects

Science projects are excellent tools for older kids to demonstrate their knowledge of science. They can also be used in various environments, including classrooms, homeschools, and groups.

Kids can take everything they have learned about using the scientific method , stating a hypothesis, choosing variables , and analyzing and presenting data.

Want to turn one of these fun chemistry experiments into a science project? Then you will want to check out these helpful resources.

• Easy Science Fair Projects
• Science Project Tips From A Teacher
• Science Fair Board Ideas

More Helpful Science Resources

Here are a few resources that will help you introduce science more effectively to your kiddos or students and feel confident yourself when presenting materials. You’ll find helpful free printables throughout.

• Best Science Practices (as it relates to the scientific method)
• Science Vocabulary
• 8 Science Books for Kids
• All About Scientists
• Free Science Worksheets
• Science Supplies List
• Science Tools for Kids
• Scientific Method for Kids
• Citizen Science Guide
• Join us in the Club

Printable Science Projects For Kids

If you’re looking to grab all of our printable science projects in one convenient place plus exclusive worksheets and bonuses like a STEAM Project pack, our Science Project Pack is what you need! Over 300+ Pages!

• 90+ classic science activities  with journal pages, supply lists, set up and process, and science information.  NEW! Activity-specific observation pages!
• Best science practices posters  and our original science method process folders for extra alternatives!
• Be a Collector activities pack  introduces kids to the world of making collections through the eyes of a scientist. What will they collect first?
• Know the Words Science vocabulary pack  includes flashcards, crosswords, and word searches that illuminate keywords in the experiments!
• My science journal writing prompts  explore what it means to be a scientist!!
• Bonus STEAM Project Pack:  Art meets science with doable projects!
• Bonus Quick Grab Packs for Biology, Earth Science, Chemistry, and Physics

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September 24, 2024

As Earth’s Climate Unravels, More Scientists Are Ready to Test Geoengineering

More and more climate scientists are supporting experiments to cool Earth by altering the stratosphere or the ocean

By Mark Fischetti

Meinzahn/Getty Images

As recently as 10 years ago most scientists I interviewed and heard speak at conferences did not support geoengineering as a way to counteract climate change. Whether the idea was to release large amounts of sulfur dioxide into the stratosphere to “block” the sun’s heating or to spread iron across the ocean to supercharge algae that breathe in carbon dioxide, researchers resisted on principle: don’t mess with natural systems because unintended consequences could ruin Earth. They also worried that trying the techniques even at a small scale could be a slippery slope to wider deployment, and that countries would use the promise of geoengineering as an excuse to keep burning carbon-emitting fossil fuels.

But today more and more climate scientists openly support experimenting with these and other proposed strategies, in part because entrepreneurs and organizations are going ahead with the methods anyway—often based on little data or field trials. Scientists want to run controlled experiments to see if the methods are productive, to test consequences and perhaps to show objectively that the approaches can cause serious problems.

“We do need to try the techniques to figure them out,” says Rob Jackson, a professor at Stanford University, chair of the international research partnership Global Carbon Project and author of a book on climate solutions called Into the Clear Blue Sky (Scribner, 2024). “But doing research does make them more likely to happen. That is the knotty part of all this.”

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A tacit race may be starting among scientists and entrepreneurs. More funding is being offered to researchers, and investments are growing in companies that would pursue geoengineering. In 2023 a start-up called Make Sunsets launched balloons containing sulfur dioxide into the stratosphere, selling “cooling credits” to companies and individuals. In early September, 23 academics at the not-for-profit consortium Exploring Ocean Iron Solutions unveiled a plan to assess how much CO 2 iron fertilization could sequester in the deep sea, and they hope to start trials across the northeastern Pacific Ocean in 2026. Big corporations, including oil companies, are already building large industrial facilities to pull CO 2 from the air, and the U.S. government is offering them billions of dollars.

There is confusion, too. Some scientists say the term “geoengineering” should refer only to techniques that alter Earth systems. For example, sulfur dioxide in the stratosphere creates tiny droplets that reflect incoming sunlight back to space, an approach called solar radiation management (SRM). But this method could also affect weather patterns or weaken the ozone layer that protects us from ultraviolet radiation. Brightening clouds by spraying them with ocean mist from below can reduce sunlight but could interfere with rain patterns. Spreading iron across the ocean helps phytoplankton to grow and consume CO 2 , yet these organisms would also consume other nutrients, which could possibly starvesea life. Spreading certain kinds of pulverized rock across the sea surface can make the water more alkaline, allowing it to absorb more CO 2 from the air, but it could affect ocean chemistry, too.

In contrast, using machines to pull CO 2 from the air, a technique known as direct air capture (DAC), doesn’t directly interfere with natural systems and so shouldn’t be called geoengineering, some argue. Social concerns could still be high, however; for example, millions of these machines would be needed to reduce warming by a meaningful extent, and that would require huge amounts of energy. If they were powered by wind and solar, as they ideally would be to avoid more greenhouse gas emissions, the installations could compete with agriculture for land.

For years Jackson refused to endorse DAC, but he now supports research. He has come around because warming is rising relentlessly, along with fossil fuel use, creating dangerous floods, droughts and heat waves that are killing people worldwide. “We are out of time and options,” he says, “an unfortunate outcome of our inaction on climate.”

He is not quite ready to endorse SRM, he says, “because I don’t trust our ability to do it equitably around the world.” Blocking the sun above certain countries could alter rainfall patterns elsewhere, which could be particularly problematic if it occurred in poorer regions. Research shows that the huge 1991 Mount Pinatubo volcanic eruption in the Philippines, which lofted about 20 million metric tons of sulfur dioxide into the stratosphere, ended up exacerbating drought in parts of the world as well as reducing ozone levels by a small percentage. If one country launches sulfur into the stratosphere, Jackson asks, who is going to pay for drought that happens in another country?

When Ken Caldeira, a longtime climate researcher at the Carnegie Institution for Science’s Department of Global Ecology at Stanford, started to look into geoengineering in 2000, he says, older researchers warned him that delving into the taboo topic would put his career at risk. Small studies did ensue, but public opinion against geoengineering mounted and most work stopped.

A big change came in 2018, when the Intergovernmental Panel on Climate Change released its Global Warming of 1.5°C report. It stated that without carbon removal or other techniques, the world stood little chance of holding warming to no more than 1.5 degrees Celsius (2.7 degrees Fahrenheit) above preindustrial levels, the goal agreed on in the 2015 Paris climate agreement. “That was an inflection point,” Jackson says. “It pointed out the difficulty, almost the futility, of reaching the 1.5-degree-C target, or even the two-degree-C target, without carbon removal.” Even if carbon removal is not considered geoengineering, the report bolstered some scientists’ willingness to experiment.

David Keith, formerly an applied physics professor and public policy professor at Harvard University, is among them, and he prefers the term “climate engineering” to refer to techniques such as SRM. For more than two decades, Keith has been looking into SRM. In 2021 he and others were about to carry out the world’s first field trial in Sweden, but protests by Indigenous peoples and other groups persuaded the Swedish government to cancel it . Last year the University of Chicago hired Keith to oversee a new program called the Climate Systems Engineering initiative, perhaps the first program to hire people specifically to do SRM research. Keith refutes the slippery slope argument, too. “There is no ethical argument for not pursuing research,” he says.

Nevertheless, many scientists and environmental groups remain skeptical—and they have been voicing their wariness to Scientific American . Lili Fuhr, an analyst at the Center for International Environmental Law, interviewed for an article on DAC in SciAm ’s September issue , said, “the reliance on these future speculative techno fixes delays real climate action right now.” Deep-sea expert Lisa Levin of the Scripps Institution of Oceanography, interviewed for a September 12 article about iron fertilization, said the technique is likely to “affect something that we don’t really understand yet.”

But to Caldeira, who is credited with coining the term “solar radiation management” in 2006, that is the reason to do “outdoor research”—not just computer modeling studies. “The key is identifying what could go wrong, and demonstrating how,” he says. “What experiment could you do to narrow the uncertainty about whether a technique is bad or okay?” If the outcomes raise threats to the environment or people, he says, “we should know that now.”

Although Caldeira is not pursuing it, one intriguing idea would be to equip a fast-mobilizing aircraft team that could fly a specially outfitted plane above a sudden volcanic eruption to test all sorts of stratospheric parameters. But it would be difficult to spend money on a special aircraft that, most of the time, would sit idle in a hangar.

Caldeira thinks support for SRM will continue to broaden, especially if drought and famine caused by climate change—which have already begun—happen year after year and disproportionately affect poorer countries. “SRM is the only way to start cooling the Earth within a few years,” he says. “There would be mounting pressure on political leaders [in poorer affected countries] to deploy it. Or at least, they could use the threat of SRM to get more aid from wealthy countries.”

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Enhanced plasmonic scattering imaging via deep learning–based super-resolution reconstruction for exosome imaging

• Paper in Forefront
• Published: 24 September 2024

Cite this article

• Zhaochen Huo 1   na1 ,
• Bing Chen 2   na1 ,
• Zhan Wang 1   na1 ,
• Boheng Hu 1 ,
• Haoliang Li 1 ,
• Pengfei Wang 1 ,
• Jianning Yao 2 ,
• Feng Xu 2 ,
• Ya Li 2 &
• Xiaonan Yang 1  

Exosome analysis plays pivotal roles in various physiological and pathological processes. Plasmonic scattering microscopy (PSM) has proven to be an excellent label-free imaging platform for exosome detection. However, accurately detecting images scattered from exosomes remains a challenging task due to noise interference. Herein, we proposed an image processing strategy based on a new blind super-resolution deep learning neural network, named ESRGAN-SE, to improve the resolution of exosome PSI images. This model can obtain super-resolution reconstructed images without increasing experimental complexity. The trained model can directly generate high-resolution plasma scattering images from low-resolution images collected in experiments. The results of experiments involving the detection of light scattered by exosomes showed that the proposed super-resolution detection method has strong generalizability and robustness. Moreover, ESRGAN-SE achieved excellent results of 35.52036, 0.09081, and 8.13176 in terms of three reference-free image quality assessment metrics, respectively. These results show that the proposed network can effectively reduce image information loss, enhance mutual information between pixels, and decrease feature differentiation. And, the single-image SNR evaluation score of 3.93078 also showed that the distinction between the target and the background was significant. The suggested model lays the foundation for a potentially successful approach to imaging analysis. This approach has the potential to greatly improve the accuracy and efficiency of exosome analysis, leading to more accurate cancer diagnosis and potentially improving patient outcomes.

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Gleadle J, McNicholas K, Li J, Michael M, Rojas-Canales D. Nanoparticle tracking analysis of urine to detect exosomes can be confounded by albuminuria. J Am Soc Nephrol. 2018;29:1784.

Article   PubMed   PubMed Central   Google Scholar  

Moon PG, Lee JE, Cho YE, Lee SJ, Chae YS, Jung JH, Kim IS, Park HY, Baek MC. Fibronectin on circulating extracellular vesicles as a liquid biopsy to detect breast cancer. Oncotarget. 2016;7:40189–99.

Chen H, Zhou L, Li C, He X, Huang J, Yang X, Shi H, Wang K, Liu J. Controlled dimerization of artificial membrane receptors for transmembrane signal transduction. Chem Sci. 2021;12:8224–30.

Article   PubMed   PubMed Central   CAS   Google Scholar  

Sokolova V, Ludwig A, Hornung S, Rotan O, Horn PA, Epple M, Giebel B. Characterisation of exosomes derived from human cells by nanoparticle tracking analysis and scanning electron microscopy. Colloids Surf B Biointerfaces. 2011;87:146–50.

Article   PubMed   CAS   Google Scholar  

Pournaghi M, Khodavirdilou R, Saadatlou MA, Nasimi FS, Yousefi S, Mobarak H, Darabi M, Shanazi V, Rahbarghazi R, Mahdipour M. Effect of melatonin on exosomal dynamics in bovine cumulus cells. Process Biochem. 2021;106:78–87.

Article   CAS   Google Scholar  

Thane KE, Davis AM, Hoffman AM. Improved methods for fluorescent labeling and detection of single extracellular vesicles using nanoparticle tracking analysis. Sci Rep. 2019;9:12295.

Chen W, Li J, Wei X, Fan Y, Qian H, Li S, Xiang Y, Ding S. Surface plasmon resonance biosensor using hydrogel-AuNP supramolecular spheres for determination of prostate cancer-derived exosomes. Mikrochim Acta. 2020;187(11):590.

Dai S, Yu T, Zhang J, Lu H, Dou J, Zhang M, Dong C, Di J, Zhao J. Real-time and wide-field mapping of cell-substrate adhesion gap and its evolution via surface plasmon resonance holographic microscopy. Biosens Bioelectron. 2021;174:112826.

Yang Y, Zhai C, Zeng Q, Khan AL, Yu H. Multifunctional detection of extracellular vesicles with surface plasmon resonance microscopy. Anal Chem. 2020;92(7):4884–90.

Wu W, Yu X, Wu J, Wu T, Fan Y, Chen W, Zhao M, Wu H, Li X, Ding S. Surface plasmon resonance imaging-based biosensor for multiplex and ultrasensitive detection of NSCLC-associated exosomal miRNAs using DNA programmed heterostructure of Au-on-Ag. Biosens Bioelectron. 2021;175:112835.

Zhang P, Zhou X, Wang R, Jiang J, Wan Z, Wang S. Label-free imaging of nanoscale displacements and free-energy profiles of focal adhesions with plasmonic scattering microscopy. ACS Sens. 2021;6:4244–54.

Zhang P, Jiang J, Zhou X, Kolay J, Wang R, Wan Z, Wang S. Label-free imaging and biomarker analysis of exosomes with plasmonic scattering microscopy. Chem Sci. 2022;13(43):12760–8.

Ma G, Zhang P, Zhou X, Wan Z, Wang S. Label-free single-molecule pulldown for the detection of released cellular protein complexes. ACS Cent Sci. 2022;8(9):1272–81.

Zhang P, Ma G, Dong W, Wan Z, Wang S, Tao N. Plasmonic scattering imaging of single proteins and binding kinetics. Nat Methods. 2020;17(10):1010–7.

Zhang P, Ma G, Wan Z, Wang S. Quantification of single-molecule protein binding kinetics in complex media with prism-coupled plasmonic scattering imaging. ACS Sens. 2021;6(3):1357–66.

Wang R, Jiang J, Zhou X, Wan Z, Zhang P, Wang S. Rapid regulation of local temperature and transient receptor potential vanilloid 1 ion channels with wide-field plasmonic thermal microscopy. Anal Chem. 2022;94(42):14503–8.

Zhang P, Zhou X, Wang S. Plasmonic scattering microscopy for label-free imaging of molecular binding kinetics: from single molecules to single cells. Chem Methods. 2023;3(6):e202200066.

Xu Y, Wang X, Zhai C, Wang J, Zeng Q, Yang Y, Yu H. A single-shot autofocus approach for surface plasmon resonance microscopy. Anal Chem. 2021;93(4):2433–9.

Song M, Ma Y, Liu H, Hu P, Huang C, Zhou J. High resolution of plasmonic resonance scattering imaging with deep learning. Anal Chem. 2022;94(11):4610–6.

Li W, Zhou K, Qi L, Lu L, Jiang N, Lu J, Jia J. Best-buddy GANs for highly detailed image super-resolution. AAAI Conf Artif Intell. 2021. https://doi.org/10.1609/aaai.v36i2.20030 .

Article   Google Scholar  

Kim J, Choi Y, Uh Y. Feature statistics mixing regularization for generative adversarial networks. IEEE/CVF Conference on Computer Vision and Pattern Recognition. 2022;11284–11293.

Wang X, Xie L, Dong C, Shan Y. Real-ESRGAN: training real-world blind super-resolution with pure synthetic data. IEEE/CVF International Conference on Computer Vision Workshops. 2021;1905–1914.

Hu J, Shen L, Albanie S, Sun G, Wu E. Squeeze-and-excitation networks. IEEE Trans Pattern Anal Mach Intell. 2020;42(8):2011–23.

Article   PubMed   Google Scholar  

Ma Y, Li S, Ye S, Luo S, Wei L, Su Y, Zeng Y, Shi Y, Bian H, Xiao F. The role of miR-222-2p in exosomes secreted by hexavalent chromium-induced premature senescent hepatocytes as a SASP component. Environ Pollut. 2024;346:123535.

Wang X, Yu K, Wu S, Gu J, Liu Y, Dong C, Loy CC, Qiao Y, Tang X. ESRGAN: enhanced super-resolution generative adversarial networks. ECCV Workshops. 2018. https://doi.org/10.1007/978-3-030-11021-5_5 .

Ledig C, Theis L, Huszár F, Caballero J, Aitken AP, Tejani A, Totz J, Wang Z, Shi W. Photo-realistic single image super-resolution using a generative adversarial network. IEEE Conference on Computer Vision and Pattern Recognition. 2017;105–114.

Zhang K, Liang J, Gool LV, Timofte R. Designing a practical degradation model for deep blind image super-resolution. IEEE/CVF International Conference on Computer Vision. 2021;4771–4780.

Mittal A, Moorthy AK, Bovik AC. No-reference image quality assessment in the spatial domain. IEEE Trans Image Process. 2021;21:4695–708.

Chen X, Zhang Q, Lin M, Yang G, He C. No-reference color image quality assessment: from entropy to perceptual quality. EURASIP J Image Video Proc. 2019. https://doi.org/10.1186/s13640-019-0479-7 .

Mittal A, Soundararajan R, Bovik AC. Making a “completely blind” image quality analyzer. IEEE Signal Process Lett. 2013;20:209–12.

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Acknowledgements

We thank volunteers from the First Affiliated Hospital of Zhengzhou University for providing blood samples.

This work was supported by the National Key Research and Development Program of China (2023YFB3611700); the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB44000000); the Medical Science and Technology Research Program of Henan Province (SBGJ202101018); the Health Commission of Henan Province (YXKC2021055); and the Science and Technology Research Program of Henan Province (232102311187).

Author information

Zhaochen Huo, Bing Chen, and Zhan Wang contributed equally.

Authors and Affiliations

School of Electrical and Information Engineering, Zhengzhou University, Zhengzhou, Henan, 450001, PR China

Zhaochen Huo, Zhan Wang, Yu Li, Lei He, Boheng Hu, Haoliang Li, Pengfei Wang & Xiaonan Yang

Department of Gastroenterology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China

Bing Chen, Jianning Yao, Feng Xu & Ya Li

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Contributions

Conceptualization, Z.H. Writing—original draft, Z.H. Writing—review and editing, Z.H., B.C., Z.W., Y.L., L.H., B.H., H.L., P.W., J.Y., F.X., Y.L., and X.Y. All authors have read and agreed to the published version of the manuscript.

Corresponding authors

Correspondence to Ya Li or Xiaonan Yang .

Ethics declarations

Ethics approval.

This study was approved by the Institutional Ethical Review Board of the First Affiliated Hospital of Zhengzhou University. All methods were performed in accordance with the ethical guidelines and regulations. The subjects recruited had informed consent to participate in this research. The blood samples used in this study were collected with the consent of volunteers from the First Affiliated Hospital of Zhengzhou University.

Source of biological material

Blood samples were provided by volunteers from the First Affiliated Hospital of Zhengzhou University.

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The authors declare no competing interests.

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Supplementary Information

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216_2024_5550_MOESM1_ESM.docx

Supplementary file1 Detailed optical design, data processing, model training performance, raw data of evaluation indicators, and signal-to-noise ratio analysis of nanoparticle images (DOCX 5665 KB)

Supplementary file2 Differential video of the dynamic binding process with strong background noise (MOV 1) (MP4 5282 KB)

Supplementary file3 Differential video of the dynamic binding process with weak background noise (MOV 2) (MP4 5254 KB)

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Huo, Z., Chen, B., Wang, Z. et al. Enhanced plasmonic scattering imaging via deep learning–based super-resolution reconstruction for exosome imaging. Anal Bioanal Chem (2024). https://doi.org/10.1007/s00216-024-05550-z

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Received : 20 June 2024

Revised : 14 August 2024

Accepted : 10 September 2024

Published : 24 September 2024

DOI : https://doi.org/10.1007/s00216-024-05550-z

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