(PDF) Statins and the Risk, Mechanism and Research Progress of New
Statins and insulin resistance and diabetes
(PDF) Statin induced diabetes and its clinical implications
Study links statin use with diabetes progression, points to need for
Statins and Diabetes: Everything You Need to Know
Statins and type 2 diabetes: genetic studies on target
VIDEO
Study Finds Website Effective in Determining Eligibility for Statins
Scientists are striving to develop longer-acting diabetes drugs
COMMENTS
Effects of statin therapy on diagnoses of new-onset diabetes and
Statin therapy increases the risk of new-onset diabetes by 10% to 36% compared with placebo, depending on the intensity of statin. The excess risk is mostly among people with baseline glycaemia close to the diagnostic threshold for diabetes.
Risk of diabetes with statins
Statins are associated with a small increased risk of new-onset diabetes, which is higher in people with other risk factors for diabetes, and in association with high intensity statins and older age. The web page provides a practice pointer for clinicians to advise patients on statins and diabetes risk, and to monitor blood glucose levels.
Statin Treatment-Induced Development of Type 2 Diabetes: From Clinical
1. Introduction. Statins are a guideline-directed, first line therapy for prevention of primary and secondary cardiovascular disease (CVD), which is the leading cause of mortality worldwide [1,2].Although the principal mechanism of the action of statins is inhibition of 3-hydroxy-3-methyl-glutaryl coenzyme-A (HMG-CoA) reductase, statins have been implicated in several other beneficial ...
Statins: Is It Really Time to Reassess Benefits and Risks?
Similarly, a meta-analysis of 13 randomized statin trials with 91,140 participants showed an odds ratio of 1.09 for a new diagnosis of diabetes, so that (on average) treatment of 255 patients with ...
Statins and risk of type 2 diabetes: mechanism and clinical
2. The first evidence that statins increase the risk of T2D. The first study showing that statins were associated with the risk of T2D was the WOSCOPS trial (West of Scotland Coronary Prevention Study) ().A total of 5 974 participants did not have diabetes at baseline and 139 of them developed T2D during the study.
Researchers solve mystery of how statins improve blood vessel health
The findings provide new insight into statins' curiously wide-ranging benefits, for conditions ranging from arteriosclerosis to diabetes, that have long been observed in the clinic. ... at the Stanford Cardiovascular Institute and co-lead author of the study published May 8 in Nature Cardiovascular Research.
How clinically relevant is statin-induced diabetes?
A meta-analysis of 23 trials shows that statins increase the risk of new-onset diabetes and worsen glycaemia in people with diabetes. The authors discuss the balance of benefits and harms of statins and the importance of prevention and monitoring strategies.
Statins may increase diabetes, but benefit still outweighs risk
The Women's Health Initiative 6 recruited 161,808 postmenopausal women without diabetes mellitus at baseline, of whom 153,840 had enough data to be analyzed post hoc. Statin therapy was associated with a 71% higher risk of new-onset diabetes mellitus (self-reported). After adjustment for age, body mass index, family history of diabetes, and other variables, the risk was still 48% higher in ...
Lipid Disorders Management Strategies (2024) in Prediabetic and
The development of new agents for the treatment of dyslipidaemia is, currently, one of the most dynamic topics of research. From statin therapy and combinations of statins with ezetimibe, to fibrates and icosapent ethyl—oral medication administered daily—to treatments administered monthly or twice a month, such as the monoclonal antibodies ...
Statins and diabetes: What are the connections?
Thus, the impact of statin-induced new-onset diabetes on microvascular risk may not be the same as new-onset diabetes in general but, once again, more data are needed to prove this point. Summary. Of all the lipid-lowering agents, statins have the best evidence to support a small, but significant impact on the development of new-onset diabetes.
Statin-Related New-Onset Diabetes Appears Driven by Increased Insulin
Additional research is needed to further validate this schema regarding the sequence of the evolution of NOD2 with statins, as well as to refine its predictors and treatments to prevent it. ... Lee S, Choi YJ, Park RW, Lim HS. Statins and risk for new-onset diabetes mellitus: a real-world cohort study using a clinical research database ...
Common Statins: Head-to-Head Study Looks at Effectiveness and Diabetes
A clinical trial compared rosuvastatin and atorvastatin for preventing heart disease in people with coronary artery disease. Rosuvastatin had lower LDL cholesterol but higher diabetes and cataract ...
Statins and Risk of New-Onset Diabetes Mellitus
Statins have a long track record of improving clinical outcomes in patients with high LDL cholesterol. Treatment of elevated LDL cholesterol levels with statins leads to a dramatic drop in the risk of heart attack, stroke, and death from cardiovascular causes in those with and without diabetes mellitus (Figure A). 2 Over 4 years, for every 40-mg/dL drop in the LDL cholesterol level, there is a ...
Statins and Diabetes: How Big Is the Risk?
A new study found that statins may double the risk of diabetes, but the absolute risk is small and the benefits of reducing cardiovascular risk outweigh the risks. The American Heart Association issued a statement on statin safety and emphasized the importance of lifestyle changes for both diabetes and cardiovascular prevention.
The Role of Statins in Diabetes Treatment
In one meta-analysis, statins were associated with a 9% increased risk (an absolute difference of about 0.4%) of developing diabetes. To cause a new case of diabetes, 255 patients would have to be treated for a mean of 4 years. 64 Compared to low-dose therapy, intensive therapy is associated with a 12% increase in risk of diabetes with a number ...
Statins and Diabetes: Is There a Connection?
Even still, the association between statins and diabetes is strong enough that in 2012, the U.S. Food and Drug Association (FDA) approved changes in the labeling of high-intensity statins to ...
Latest statins guidance keeps more conservative approach to ...
In the past there had been some concern that statins may elevate a person's risk for muscle problems or diabetes, but other than one study that involved high-intensity statin therapy, on the ...
854-P: Statin Use and New-Onset Diabetes in People with Prediabetes
Statins lower the risk of cardiovascular disease, yet may adversely affect glucose metabolism. In the D2d study, which evaluated the effect of vitamin D versus placebo in a contemporary cohort of people with high-risk prediabetes (n=2,423) , we evaluated the association between statin use at baseline and progression to diabetes.
Statin-induced diabetes: incidence, mechanisms, and implications
Emergence of new diabetes in RCTs. A clinically relevant concern with statin therapy is a significantly increased risk of new-onset diabetes in patients on statin therapy. The JUPITER trial reported a 25% increase with rosuvastatin 20 mg, over a median follow-up of 1.9 years, compared to those on placebo 9.
Cholesterol drug reduces heart attack and death risk: research
In the new research, Nissen and his colleagues focused only on participants who had never been diagnosed with heart disease, but were at high risk because of factors such as high LDL, diabetes and ...
Statin Use for the Primary Prevention of Cardiovascular Disease ...
For adults aged 40 to 75 years: Determine whether the patient has a cardiovascular risk factor (i.e., dyslipidemia, diabetes, hypertension, or smoking). Estimate CVD risk using a CVD risk ...
Lifetime effects and cost-effectiveness of statin therapy for older
Background Cardiovascular disease (CVD) risk increases with age. Statins reduce cardiovascular risk but their effects are less certain at older ages. We assessed the long-term effects and cost-effectiveness of statin therapy for older people in the contemporary UK population using a recent meta-analysis of randomised evidence of statin effects in older people and a new validated CVD model.
Stem cells reverse woman's diabetes
A woman with type 1 diabetes started producing insulin (blue) after a stem cell transplant. Credit: Lennart Nilsson, Boehringer Ingelheim International GmbH, TT/Science Photo Library
Diabetes Registries Could Help Address Wobbly Data Dilemma
Pan-European diabetes data registries need infrastructure and funding to ensure optimal decision-making in clinical practice, research, and policy. This site is intended for healthcare professionals
Lidl's new £1.99 drink busts cholesterol and boosts fatty liver health
Research suggests that consuming 2g of phytosterols daily can lead to an 8% to 10% decrease in LDL cholesterol. People who are on statins or ezetimibe, a medication for lowering cholesterol, may ...
Life-saving anti-cholesterol drug recommended on NHS thanks to
It results in astonishing reductions in blood cholesterol, far exceeding that achieved by high dose statins, with virtually no side effects. "It is gratifying that NICE is recommending its use and this clearly demonstrates the benefits to patients of well conducted clinical trials as part of a major NIHR CRN collaboration with Novartis, NHS ...
Statin induced diabetes and its clinical implications
A lot of research is currently going on to elucidate mechanisms of statin induced diabetes at the molecular level. ... Welton N, Fabiszak T, et al. Meta-analysis of impact of different types and doses of statins on new-onset diabetes mellitus. Am J Cardiol. 2013; 111:1123-30. [Google Scholar] 11.
Harnessing cellular therapeutics for type 1 diabetes mellitus: progress
The Diabetes Research Institute (DRI) and Foundation were created for one reason - to cure diabetes - which is and will continue to be the singular focus until that goal is reached. As one of the largest and most comprehensive research centers dedicated to curing diabetes, the DRI is working to restore natural insulin production and ...
Diabetes, Prediabetes, and Brain Aging: The Role of Healthy Lifestyle
The study included 31,229 dementia-free adults from the UK Biobank between the ages of 40 and 70 years. Glycemic status (normoglycemia, prediabetes, or diabetes) was ascertained based on medical history, medication use, and HbA 1c measured at baseline. Information on cardiometabolic risk factors (obesity, hypertension, low HDL, and high triglycerides) and lifestyle behaviors (smoking, drinking ...
IMAGES
VIDEO
COMMENTS
Statin therapy increases the risk of new-onset diabetes by 10% to 36% compared with placebo, depending on the intensity of statin. The excess risk is mostly among people with baseline glycaemia close to the diagnostic threshold for diabetes.
Statins are associated with a small increased risk of new-onset diabetes, which is higher in people with other risk factors for diabetes, and in association with high intensity statins and older age. The web page provides a practice pointer for clinicians to advise patients on statins and diabetes risk, and to monitor blood glucose levels.
1. Introduction. Statins are a guideline-directed, first line therapy for prevention of primary and secondary cardiovascular disease (CVD), which is the leading cause of mortality worldwide [1,2].Although the principal mechanism of the action of statins is inhibition of 3-hydroxy-3-methyl-glutaryl coenzyme-A (HMG-CoA) reductase, statins have been implicated in several other beneficial ...
Similarly, a meta-analysis of 13 randomized statin trials with 91,140 participants showed an odds ratio of 1.09 for a new diagnosis of diabetes, so that (on average) treatment of 255 patients with ...
2. The first evidence that statins increase the risk of T2D. The first study showing that statins were associated with the risk of T2D was the WOSCOPS trial (West of Scotland Coronary Prevention Study) ().A total of 5 974 participants did not have diabetes at baseline and 139 of them developed T2D during the study.
The findings provide new insight into statins' curiously wide-ranging benefits, for conditions ranging from arteriosclerosis to diabetes, that have long been observed in the clinic. ... at the Stanford Cardiovascular Institute and co-lead author of the study published May 8 in Nature Cardiovascular Research.
A meta-analysis of 23 trials shows that statins increase the risk of new-onset diabetes and worsen glycaemia in people with diabetes. The authors discuss the balance of benefits and harms of statins and the importance of prevention and monitoring strategies.
The Women's Health Initiative 6 recruited 161,808 postmenopausal women without diabetes mellitus at baseline, of whom 153,840 had enough data to be analyzed post hoc. Statin therapy was associated with a 71% higher risk of new-onset diabetes mellitus (self-reported). After adjustment for age, body mass index, family history of diabetes, and other variables, the risk was still 48% higher in ...
The development of new agents for the treatment of dyslipidaemia is, currently, one of the most dynamic topics of research. From statin therapy and combinations of statins with ezetimibe, to fibrates and icosapent ethyl—oral medication administered daily—to treatments administered monthly or twice a month, such as the monoclonal antibodies ...
Thus, the impact of statin-induced new-onset diabetes on microvascular risk may not be the same as new-onset diabetes in general but, once again, more data are needed to prove this point. Summary. Of all the lipid-lowering agents, statins have the best evidence to support a small, but significant impact on the development of new-onset diabetes.
Additional research is needed to further validate this schema regarding the sequence of the evolution of NOD2 with statins, as well as to refine its predictors and treatments to prevent it. ... Lee S, Choi YJ, Park RW, Lim HS. Statins and risk for new-onset diabetes mellitus: a real-world cohort study using a clinical research database ...
A clinical trial compared rosuvastatin and atorvastatin for preventing heart disease in people with coronary artery disease. Rosuvastatin had lower LDL cholesterol but higher diabetes and cataract ...
Statins have a long track record of improving clinical outcomes in patients with high LDL cholesterol. Treatment of elevated LDL cholesterol levels with statins leads to a dramatic drop in the risk of heart attack, stroke, and death from cardiovascular causes in those with and without diabetes mellitus (Figure A). 2 Over 4 years, for every 40-mg/dL drop in the LDL cholesterol level, there is a ...
A new study found that statins may double the risk of diabetes, but the absolute risk is small and the benefits of reducing cardiovascular risk outweigh the risks. The American Heart Association issued a statement on statin safety and emphasized the importance of lifestyle changes for both diabetes and cardiovascular prevention.
In one meta-analysis, statins were associated with a 9% increased risk (an absolute difference of about 0.4%) of developing diabetes. To cause a new case of diabetes, 255 patients would have to be treated for a mean of 4 years. 64 Compared to low-dose therapy, intensive therapy is associated with a 12% increase in risk of diabetes with a number ...
Even still, the association between statins and diabetes is strong enough that in 2012, the U.S. Food and Drug Association (FDA) approved changes in the labeling of high-intensity statins to ...
In the past there had been some concern that statins may elevate a person's risk for muscle problems or diabetes, but other than one study that involved high-intensity statin therapy, on the ...
Statins lower the risk of cardiovascular disease, yet may adversely affect glucose metabolism. In the D2d study, which evaluated the effect of vitamin D versus placebo in a contemporary cohort of people with high-risk prediabetes (n=2,423) , we evaluated the association between statin use at baseline and progression to diabetes.
Emergence of new diabetes in RCTs. A clinically relevant concern with statin therapy is a significantly increased risk of new-onset diabetes in patients on statin therapy. The JUPITER trial reported a 25% increase with rosuvastatin 20 mg, over a median follow-up of 1.9 years, compared to those on placebo 9.
In the new research, Nissen and his colleagues focused only on participants who had never been diagnosed with heart disease, but were at high risk because of factors such as high LDL, diabetes and ...
For adults aged 40 to 75 years: Determine whether the patient has a cardiovascular risk factor (i.e., dyslipidemia, diabetes, hypertension, or smoking). Estimate CVD risk using a CVD risk ...
Background Cardiovascular disease (CVD) risk increases with age. Statins reduce cardiovascular risk but their effects are less certain at older ages. We assessed the long-term effects and cost-effectiveness of statin therapy for older people in the contemporary UK population using a recent meta-analysis of randomised evidence of statin effects in older people and a new validated CVD model.
A woman with type 1 diabetes started producing insulin (blue) after a stem cell transplant. Credit: Lennart Nilsson, Boehringer Ingelheim International GmbH, TT/Science Photo Library
Pan-European diabetes data registries need infrastructure and funding to ensure optimal decision-making in clinical practice, research, and policy. This site is intended for healthcare professionals
Research suggests that consuming 2g of phytosterols daily can lead to an 8% to 10% decrease in LDL cholesterol. People who are on statins or ezetimibe, a medication for lowering cholesterol, may ...
It results in astonishing reductions in blood cholesterol, far exceeding that achieved by high dose statins, with virtually no side effects. "It is gratifying that NICE is recommending its use and this clearly demonstrates the benefits to patients of well conducted clinical trials as part of a major NIHR CRN collaboration with Novartis, NHS ...
A lot of research is currently going on to elucidate mechanisms of statin induced diabetes at the molecular level. ... Welton N, Fabiszak T, et al. Meta-analysis of impact of different types and doses of statins on new-onset diabetes mellitus. Am J Cardiol. 2013; 111:1123-30. [Google Scholar] 11.
The Diabetes Research Institute (DRI) and Foundation were created for one reason - to cure diabetes - which is and will continue to be the singular focus until that goal is reached. As one of the largest and most comprehensive research centers dedicated to curing diabetes, the DRI is working to restore natural insulin production and ...
The study included 31,229 dementia-free adults from the UK Biobank between the ages of 40 and 70 years. Glycemic status (normoglycemia, prediabetes, or diabetes) was ascertained based on medical history, medication use, and HbA 1c measured at baseline. Information on cardiometabolic risk factors (obesity, hypertension, low HDL, and high triglycerides) and lifestyle behaviors (smoking, drinking ...