pharmacology related research topics

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 40+ Pharmacology Research Topics: A Comprehensive Guide for Nursing Students

Carla johnson.

• August 24, 2023
• Essay Topics and Ideas

Understanding pharmacology is crucial for nursing students as it forms the foundation of safe and effective patient care. This article aims to give nursing students insights into pharmacology research topics and potential research directions.

What You'll Learn

The Importance of Pharmacology in Nursing Education

Pharmacology involves studying how drugs interact with living organisms, including their effects, mechanisms, and possible side effects. Pharmacology knowledge is essential for administering medications, understanding drug interactions, and ensuring patient safety . By grasping pharmacological principles, nursing students can make informed decisions and deliver evidence-based care.

Exploring PICOT Questions in Pharmacology

• P: Adult psychiatric patients; I: Daily RS questionnaire; C: Units without daily survey; O: Reduced RS utilization; T: 6 months. Compared to units without the survey, can introducing a daily RS (Recovery Scale) questionnaire in psychiatric units lead to significantly decreased RS utilization over six months?
• P: Pediatric asthma patients; I: Peak flow monitoring; C: Standard symptom-based management; O: Decreased severe asthma exacerbations; T: 1 year. Does incorporating peak flow monitoring for pediatric asthma patients result in significantly fewer severe asthma exacerbations over a year compared to standard management?
• P: Elderly long-term care residents; I: Structured medication reconciliation; C: Informal reconciliation; O: Reduced medication discrepancies; T: 3 months. Among elderly in long-term care, does implementing structured medication reconciliation lead to significantly fewer medication discrepancies within three months compared to informal methods?
• P: Postoperative patients; I: Multimodal pain management ; C: Traditional pain management; O: Reduced opioid consumption; T: Postoperative period. Can adopting a multimodal pain management approach significantly reduce opioid consumption in postoperative patients compared to traditional methods?
• P: Diabetic patients; I: Interactive technology education; C: Conventional education; O: Improved glycemic control; T: 6 months. Among diabetic patients, does interactive technology education lead to better glycemic control over six months compared to conventional education?
• P: Oncology patients on chemotherapy ; I: Pre-chemotherapy antiemetic; C: Post-chemotherapy antiemetic; O: Reduced chemotherapy-induced nausea and vomiting; T: During chemotherapy. For oncology patients undergoing chemotherapy, does administering antiemetics before chemotherapy significantly decrease chemotherapy-induced nausea and vomiting compared to post-chemotherapy administration?
• P: Hypertensive patients; I: Home blood pressure monitoring; C: Clinic-based monitoring; O: Improved blood pressure control; T: 3 months. Does home blood pressure monitoring lead to better blood pressure control in hypertensive patients over three months compared to clinic-based monitoring?
• P: Critically ill ventilated patients; I: Early mobilization; C: Delayed mobilization; O: Shorter mechanical ventilation; T: ICU stay. Among critically ill ventilated patients, does early mobilization lead to shorter mechanical ventilation durations during ICU stays compared to delayed mobilization?
• P: Chronic pain patients; I: Mindfulness program; C: Standard pain management; O: Improved pain relief, quality of life; T: 8 weeks. Can participating in a mindfulness program lead to better pain relief and quality of life for chronic pain patients over eight weeks compared to standard pain management?
• P: Postmenopausal women; I: Calcium, vitamin D supplementation; C: No supplementation; O: Decreased bone density loss; T: 1 year. Among postmenopausal women at risk of osteoporosis, does calcium, vitamin D supplementation significantly reduce bone density loss over a year compared to no supplementation?

Evidence-Based Practice (EBP) Projects in Pharmacology

• Analyzing medication reconciliation’s impact on adverse drug events in geriatric patients.
• Comparing patient-controlled analgesia and nurse-controlled analgesia in postoperative pain management.
• Studying medication adherence’s effect on glycemic control in diabetes patients.
• Investigating antipsychotic medication use and fall risk in elderly psychiatric patients.
• Assessing pharmacogenomic testing’s role in psychiatric medication personalization.
• Comparing antiemetic agents for chemotherapy-induced nausea and vomiting prevention.
• Evaluating a structured pain assessment tool’s impact on pediatric pain management.
• Examining home blood pressure monitoring’s effect on hypertension control .
• Investigating opioid-sparing techniques in orthopedic postoperative pain management.
• Exploring herbal supplement use for managing menopausal symptoms.

Nursing Capstone Project Ideas in Pharmacology

• Designing a comprehensive medication education program for pediatric patients and caregivers.
• Developing a protocol for high-alert medication administration in critical care units.
• Creating a chronic pain interdisciplinary management plan in long-term care.
• Implementing a medication safety campaign to reduce errors in emergency departments.
• Designing a rural telehealth platform for medication counseling and adherence.
• Establishing immunosuppressive medication adverse reaction monitoring post-transplant.
• Creating a guideline for nurses in helping patients optimize polypharmacy.
• Designing a chemotherapy administration and monitoring training module.
• Developing a vasopressor medication titration protocol for septic shock.
• Creating a herbal supplement interaction resource guide.

Research Paper Topics in Pharmacology for Nursing Students

• Pharmacogenomics’ role in personalizing psychiatric medication regimens.
• Nurse contributions to preventing opioid misuse and overdose in the epidemic.
• Evaluating cultural diversity’s impact on medication beliefs and adherence.
• Strategies for optimizing medication regimens and preventing adverse effects in the elderly.
• Pharmacovigilance’s importance in monitoring and reporting adverse drug reactions.
• Herbal supplement-drug interaction evidence and practice analysis.
• Ethical considerations in pediatric medication administration.
• Antibiotic resistance’s implications and nurses’ role in prudent antibiotic use.
• Addressing medication disparities in healthcare.
• Medication errors: Causes, consequences, and prevention in nursing practice.

Understanding pharmacology is paramount for nursing students’ ability to provide safe and effective patient care. With knowledge of pharmacology, nursing students can make informed decisions and contribute to healthcare. Explore PICOT questions, research projects, and essay topics to enhance learning and engage in impactful healthcare practices. For further assistance, consider our writing services tailored to nursing students’ needs, helping you merge pharmacological knowledge with effective communication to excel in healthcare.

FAQs about Pharmacology in Nursing

Q: What is pharmacology in nursing?

A: Pharmacology in nursing studies how drugs interact with living organisms, encompassing their effects, mechanisms, and potential side effects. It’s a crucial field for nurses to ensure safe and effective patient care through proper medication administration and management.

Q: What are the 5 importance of pharmacology in nursing?

A: The importance of pharmacology in nursing includes enabling nurses to understand drug interactions, administer medications safely, manage patient responses, prevent adverse reactions, and provide evidence-based care.

Q: What are the principles of pharmacology for nurses?

A: The principles of pharmacology for nurses involve understanding drug actions, indications, contraindications, interactions, and adverse effects. It also includes proper dosage calculation, patient education , and ethical considerations.

Q: What are the types of pharmacology?

A: Pharmacology can be broadly categorized into several types, including clinical pharmacology (study of drugs in clinical settings), neuropharmacology (study of drugs affecting the nervous system), and psychopharmacology (study of drugs for mental disorders). Additionally, there’s pharmacokinetics (drug absorption, distribution, metabolism, excretion) and pharmacodynamics (drug effects on the body).

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College of Pharmacy

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Research in Experimental and Clinical Pharmacology

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Advancing the science of human pharmacology and therapeutics through translational research.

Faculty in the Department of Experimental and Clinical Pharmacology conduct clinical and translational research. This cross-disciplinary paradigm translates basic scientific discoveries into safe and effective therapeutic uses by providers and patients, through laboratory experiments and clinical studies. Clinical data can also prompt new questions and investigations, leading back to the bench and beginning a new cycle of translational research. Research conducted by department faculty can focus on a range of topics, diseases/conditions, and investigational methods. Some current and recent projects are highlighted here:

+ Alzheimer's Disease

Impact of Mitochondrial Lipidomic Dynamics and its Interaction with APOE Isoforms on Brain Aging and Alzheimer’s Disease PI: Ling Li Funding: NIH National Institute on Aging 

Acute and Long-Term Impact of SARS-CoV-2 Infection and its Interaction with APOE on Cognitive Function and Neuropathology in Aging and Alzheimer's Disease PI: Ling Li Funding: NIH National Institute on Aging 

HDL Mimetic Peptide-Mediated Enhancement of Neurovascular Function to Mitigate Cerebral Amyloid Angiopathy and Alzheimer's Disease  PI: Ling Li Funding: NIH National Institute on Aging    Dysregulation of Protein Prenylation in the Pathogenesis of Alzheimer's Disease  PI: Ling Li  Funding: NIH National Institute on Aging   Modeling and Reversing Alzheimer’s Pathology via Human Brain Organoids  PI: Ling Li Funding: Faculty Research Development Grant Program, OACA, UMN  

Drug Repurposing for Advanced Prostate Cancers PI: R. Stephanie Huang Funding: NIH National Cancer Institute

Develop Effective Combination Therapy by Imputing Cell Level Drug Sensitivity and Evaluate Them in Novel Mix-cell Model System PI: R. Stephanie Huang Funding: NIH National Cancer Institute

Novel Targeted Chemo/Immunotherapy Approach to Localized and Metastatic CaP Co-I: Mark Kirstein Funding: NIH National Cancer Institute

Combating Cellular Senescence to Prevent Anthracycline Cardiotoxicity PI: Beshay Zordoky Funding: St. Baldrick’s Foundation for Childhood Cancer Research

Psychosocial Stress Exacerbates Doxorubicin-induced Cardiovascular Aging PI: Beshay Zordoky Funding: NIH National Heart, Lung, and Blood Institute

+ Community Health and Clinical Care

Creating a 21st-Century Precision Medicine Intensive Care Unit (ICU) Co-PI: Debra Skaar Co-Is: Pamala Jacobson, Shellina Scheiner Funding: UMN College of Pharmacy

Advancing Health Through Tailored Solutions: A Community Based Approach Towards Advancing Personalized Medicine in Underserved Populations (VIP-H Study) PI: Robert Straka Co-I: Jeffrey Bishop Funding: UMN Grand Challenge Exploratory Research Award, Provost's Office

Differences in Predicted Warfarin Dose for Hmong vs. East Asians Using Genotype-based Dosing Algorithm PI: Robert Straka Funding: UMN Clinical and Translational Science Institute (CTSI)

+ Drug Dependence

Development of a Monoclonal Antibody to Reverse Overdose From Fentanyl and Its Analogs: From Manufacturing to Clinical Trials Co-I: Angela Birnbaum Funding: NIH National Institute on Drug Abuse (2022 - 2027) 

Phase 1a/1b Clinical Trials of Multivalent Opioid Vaccine Components Co-I: Angela Birnbaum Funding: NIH National Institute on Drug Abuse (2019 - 2023)

A Randomized Trial of Medical Cannabis in Patients with Advanced Cancers to Assess Impact on Opioid Use and Cancer-Related Symptoms: A Pilot Study Co-I: Angela K. Birnbaum Funding: Randy Shaver Foundation

Feasibility of Using Wearable Technology for Just-in-Time Prediction of Smoking Lapses Co-PI: Michael Kotlyar Funding: NIH National Institute on Drug Abuse

Feasibility of Using a Culturally Tailored Conversational Agent for Promoting Smoking Cessation Treatment Utilization in African Americans Who Use Cigarettes Co-PI: Michael Kotlyar Funding: NIH National Institute on Minority Health and Health Disparities 

Bupropion for the Prevention of Postpartum Smoking Relapse Co-I: Michael Kotlyar Funding: NIH National Institute on Drug Abuse

+ Infectious Diseases

Improving outcomes in HIV-associated opportunistic infectious with CNS pharmacokinetics and pharmacodynamics PI: Melanie Nicol Funding: College of Pharmacy

Encochleated Oral Amphotericin for HIV-related Cryptococcal Meningitis Trial: Phase 3 Co-I: Melanie Nicol Funding: NIH, National Institute of Neurologic Disorders and Stroke

Optimal vancomycin exposure target for pulmonary exacerbations in CF PI: Silvia M. Illamola Co-I: Elizabeth Hirsch Funding: Cystic Fibrosis Foundation (2021-2023) 

Outcomes of Immunocompromised Patients Treated with Ceftolozane/Tazobactam PI: Elizabeth Hirsch Funding: Merck Center for Observational and Real-World Evidence

A Retrospective, Multi-Center Study to Assess Patient Outcomes Following Treatment with Ceftolozane/Tazobactam (C/T) PI: Elizabeth Hirsch Funding: Merck & Co.

Pharmacology of Antiretrovirals in Anatomical Brain Tissue among Persons with Chronic HIV Infection Co-PI: Melanie Nicol Funding: NIH, National Institute of Neurological Disorders and Stroke

Evaluating Antiretroviral Pharmacology in the Female Genital Tract to Optimize HIV Prevention PI: Melanie Nicol Funding: NIH,  National Institute of for Allergies and Infectious Diseases

+ Pharmacogenomics

An Informatics Framework for Discovery and Ascertainment of Drug-Supplement Interactions Co-I: Jeffrey Bishop Funding: NIH National Center for Completmentary and Integrative Health

Pediactric CPIC Rx Study PI: Jeffrey Bishop Funding: Vanderbilt University

Gut Microbiata and Effect on Immune Suppressants in Transplantation PI: Pamala Jacobson Funding: NIH National Institute on Allergy and Infectious Disease

A Pilot Trial to Examine the Effect of Aspirin on the Gut Microbiome Co-I: Robert Straka Funding: UMN CTSI Exploratory Grants

Decipher Genetic Underlying Causes for Sex Dimorphism in Human Disease and Drug Response PI: R. Stephanie Huang Funding: NIH National Cancer Institute

Computational Projection of Drug Side Effects in Various Human Normal Tissues PI: R. Stephanie Huang Funding: NIH National Cancer Institute       

+ Pharmacometrics/Pharmacokinetic Modeling

Pharmacokinetic/Pharmacodynamic model in pregnant women with depression to guide sertraline dosing  PI: S ilvia M. Illamola, Angela Birnbaum Funding: Eunice Kennedy Shriver National Institute of Child Health and Human Development (2022 - 2024)

Physiological-based Pharmacokinetics Approach to Determine the Extent of Drug Exposure of Antiseizure Medications During Pregnancy and Breastfeeding PI: Angela Birnbaum Funding: Eunice Kennedy Shriver National Institute of Child Health and Human Development (2022 - 2024)

Comparison of the Cognitive and Motor Effects of Treatment Between an Immediate and Extended-Release Tacrolimus (Envarsus XR)-Based Immunosuppression Regimen in Kidney Transplant Recipients PI: Susan Marino Co-I: Angela Birnbaum Funding: Veloxis Pharmaceutics

+ Neuropharmacology

Epigenetics of PTSD Treatment Response PI: Jeffrey Bishop Funding: NIH National Center for Complementary and Integrative Health

Development and Application of MRI Methods to Quantify Brain Energy Impairment and Drug Responses in Neurodegenerative Disorders PIs: Lisa Coles, James C. Cloyd Funding: UMN AHC Faculty Development Grant

+ Rare Diseases

Role of Beta-Catenin in the Pathophysiology of Infantile Spasms PI: James C. Cloyd Co-I: Reena Kartha Funding: Tufts University

Role of Oxidative Stress and Inflammation in Type 1 Gaucher Disease: Potential Use of Antioxidant/Anti-Inflammatory Medications PIs: James C. Cloyd, Reena Kartha Funding: Pfizer, Inc.

Synergistic Chaperone Activity of N-acetylcysteine and Its Metabolite L-cysteine in Gaucher Disease PI: Reena Kartha Funding: Center for Orphan Drug Research (CODR), University of Minnesota

+ Seizure Disorders

Maternal Outcomes and Neurodevelopmental Effects of Antiepileptic Drugs – Pharmacokinetics Laboratory Core PI: Angela K. Birnbaum Funding: NIH National Institute of Neurological Disorders and Stroke (2012 - 2023)

Phase I Study of Midazolam Pharmacokinetics, Pharmacodynamics and Adverse Effect following Intramuscular Injection in Dogs using an Autoinjector PI: James Cloyd Co-I: Lisa Coles Funding: Mesagreen Pharmaceutical

An Exploratory, Open-label Study of the Pharmacokinetics and Pharmacodynamics of Diazepam after Intranasal Administration of a Single Dose of Valtoco to Healthy Volunteers PIs: James Cloyd, Lisa Coles Funding: Neuralis, Inc.

The Department of Experimental and Clinical Pharmacology (ECP) is located within one of the largest academic health centers in the United States, with nationally recognized programs in public health, medicine, nursing, dentistry, and veterinary medicine. Major campus research facilities include a Clinical and Translational Science Institute, the Biomedical Genomics Center, and the Masonic Cancer Center. In addition, numerous affiliated health care systems with exceptional research and educational programs partner with the COP. The Twin Cities also has a large number of cutting-edge biomedical companies eager to collaborate with the academic community.

Our regular faculty and staff are located in four buildings within the University of Minnesota's Academic Health Center on the Twin Cities campus:

• Weaver-Densford Hall
• McGuire Translational Research Facility
• 717 Delaware
• Phillips-Wangensteen Building

Several ECP faculty also work at clinical sites around the Twin Cities, directing experiential clinical residencies of fourth-year students in the College's PharmD program. These include North Memorial Medical Center and University of Minnesota Medical Center.

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• Pharmacology and Toxicology >
• Research and Facilities >

Areas of Research

Our faculty pursue research on a wide variety of topics within the discipline of pharmacology and toxicology, using cutting-edge techniques such as stem cell research and optogenetics.

Neuropharmacology

Includes research on:

• central and peripheral neurotransmission
• neurotoxicology
• nerve growth factors
• neural cytoskeletal elements

Psychopharmacology

• psychoactive drugs
• drug addiction and alcohol dependence
• behavioral pharmacology and the pharmacology of abused drugs
• novel molecules that may ameliorate the effects of drug abuse

• the environmental and clinical aspects of toxicological processes
• the effects of xenobiotics on metabolism
• the toxicity and mechanisms of halogenated aromatic hydrocarbons, such as dioxins
• heavy metals, cyclic ethers and other environmental pollutants
• toxicological effects on development, renal and pulmonary function, neural activity and immune responses

Clinical Pharmacology

• heart ischemia, cardiac pharmacology and cardiovascular disease
• pulmonary disease
• infectious disease
• neurodegenerative disorders
• pharmacological oncology
• Parkinson’s disease
• circadian rhythm disorders
• macular degeneration

Molecular and Cellular Pharmacology

• drug-receptor interactions
• signal transduction mechanisms
• calcium and calmodulin-dependent processes
• protein phosphorylation
• membrane transport
• drug-enzyme interactions
• pharmacology of antibiotics and immune responses
• regulation of gene expression
• molecular determinants of growth and differentiation of cells

Researcher Spotlight

Suzanne Laychock, PhD, is investigating the cellular mechanisms regulating insulin secretion in pancreatic cells. Her group has used pancreatic cells in primary culture to develop in vitro systems that mimic aspects of Type 1 and Type 2 diabetes.

David Dietz, PhD , investigates cellular changes by which drugs “hijack” the central nervous system’s reward circuitry, causing addiction. He studies how differences in individuals’ molecular and behavioral plasticity mediate susceptibility to drug abuse and relapse.

Fraser J. Sim, PhD , studies the molecular mechanisms controlling stem and progenitor cell fate in the human brain. His lab seeks to develop novel drug- and cell-based therapies for repair and regeneration in demyelinating diseases, such as multiple sclerosis.

James R. Olson, PhD , has traveled to Egypt to work with cotton laborers exposed to pesticides. His research links genetics, an individual’s degree of exposure to pesticides and effects on health, seeking to improve workplace and environmental health worldwide.

Margarita L. Dubocovich, PhD , works to elucidate melatonin’s mechanism of action and role in modulating circadian rhythms. Her lab develops novel molecules targeting melatonin receptors to treat depression, sleep disorders and cardiovascular disease.

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Hot Topics in Pharmacology

Coronavirus information.

We collate information related to SARS-CoV-2 and COVID-19 on a dedicated coronavirus information page . This contains details of ligands and targets relevant to COVID-19 and links to useful resources and publications.

Recent publications of interest recommended by NC-IUPHAR

2024: aug | jul | jun | may | apr | mar | jan 2023: nov | oct | sep | aug, august 2024.

• A neurodevelopmental disorder mutation locks G proteins in the transitory pre-activated state. Knight KM, Krumm BE, Kapolka NJ, Ludlam WG, Cui M, Mani S, Prytkova I, Obarow EG, Lefevre TJ, Wei W et al. . A neurodevelopmental disorder mutation locks G proteins in the transitory pre-activated state. (2024)   Nat Commun , 15 (1): 6643. [PMID: 39103320 ]
• Glutathione-Based Photoaffinity Probe Identifies Caffeine as a Positive Allosteric Modulator of the Calcium-Sensing Receptor. Matarage Don NNJ, Padmavathi R, Khasro TD, Zaman MRU, Ji HF, Ram JL, Ahn YH. Glutathione-Based Photoaffinity Probe Identifies Caffeine as a Positive Allosteric Modulator of the Calcium-Sensing Receptor. (2024)   ACS Chem Biol , 19 (7): 1661-1670. [PMID: 38975966 ]
• Cryo-EM Structure and Biochemical Analysis of the Human Chemokine Receptor CCR8. Peng Q, Jiang H, Cheng X, Wang N, Zhou S, Zhang Y, Yang T, Chen Y, Zhang W, Lv S et al. . Cryo-EM Structure and Biochemical Analysis of the Human Chemokine Receptor CCR8. (2024)   Biochemistry , [Epub ahead of print]. [PMID: 38985857 ]
• ChemFREE: a one-stop comprehensive platform for ecological and environmental risk evaluation of chemicals in one health world. Chen D, Liu Y, Liu Y, Zhao K, Zhang T, Gao Y, Wang Q, Song B, Hao G. ChemFREE: a one-stop comprehensive platform for ecological and environmental risk evaluation of chemicals in one health world. (2024)   Nucleic Acids Res , 52 (W1): W450-W460. [PMID: 38832633 ]
• The cerebellum modulates thirst. Mishra I, Feng B, Basu B, Brown AM, Kim LH, Lin T, Raza MA, Moore A, Hahn A, Bailey S et al. . The cerebellum modulates thirst. (2024)   Nat Neurosci , [Epub ahead of print]. [PMID: 38987435 ]
• The sphingosine-1-phosphate receptor 1 mediates the atheroprotective effect of eicosapentaenoic acid. Zhou T, Cheng J, He S, Zhang C, Gao MX, Zhang LJ, Sun JP, Zhu Y, Ai D. The sphingosine-1-phosphate receptor 1 mediates the atheroprotective effect of eicosapentaenoic acid. (2024)   Nat Metab , [Epub ahead of print]. [PMID: 38907081 ]
• Coordinated action of a gut-liver pathway drives alcohol detoxification and consumption. Fu Y, Mackowiak B, Lin YH, Maccioni L, Lehner T, Pan H, Guan Y, Godlewski G, Lu H, Chen C et al. . Coordinated action of a gut-liver pathway drives alcohol detoxification and consumption. (2024)   Nat Metab , [Epub ahead of print]. [PMID: 38902331 ]
• Inhibition of OSBP blocks retrograde trafficking by inducing partial Golgi degradation. He N, Depta L, Rossetti C, Caramelle L, Cigler M, Bryce-Rogers HP, Michon M, Rafn Dan O, Hoock J, Barbier J et al. . Inhibition of OSBP blocks retrograde trafficking by inducing partial Golgi degradation. (2024)   Nat Chem Biol , [Epub ahead of print]. [PMID: 38907112 ]
• Orpinolide disrupts a leukemic dependency on cholesterol transport by inhibiting OSBP. Cigler M, Imrichova H, Frommelt F, Caramelle L, Depta L, Rukavina A, Kagiou C, Hannich JT, Mayor-Ruiz C, Superti-Furga G et al. . Orpinolide disrupts a leukemic dependency on cholesterol transport by inhibiting OSBP. (2024)   Nat Chem Biol , [Epub ahead of print]. [PMID: 38907113 ]
• 3-Hydroxykynurenine targets kainate receptors to promote defense against infection. Parada-Kusz M, Clatworthy AE, Goering ER, Blackwood SM, Shigeta JY, Mashin E, Salm EJ, Choi C, Combs S, Lee JSW et al. . 3-Hydroxykynurenine targets kainate receptors to promote defense against infection. (2024)   Nat Chem Biol , [Epub ahead of print]. [PMID: 38898166 ]
• A molecular glue degrader of the WIZ transcription factor for fetal hemoglobin induction. Ting PY, Borikar S, Kerrigan JR, Thomsen NM, Aghania E, Hinman AE, Reyes A, Pizzato N, Fodor BD, Wu F et al. . A molecular glue degrader of the WIZ transcription factor for fetal hemoglobin induction. (2024)   Science , 385 (6704): 91-99. [PMID: 38963839 ]
• NN1213 - A Potent, Long-Acting, and Selective Analog of Human Amylin. Dahl K, Raun K, Hansen JL, Poulsen C, de la Cour CD, Clausen TR, Hansen AMK, John LM, Plesner A, Sun G et al. . NN1213 - A Potent, Long-Acting, and Selective Analog of Human Amylin. (2024)   J Med Chem , [Epub ahead of print]. [PMID: 38960379 ]
• A µ-opioid receptor modulator that works cooperatively with naloxone. O'Brien ES, Rangari VA, El Daibani A, Eans SO, Hammond HR, White E, Wang H, Shiimura Y, Krishna Kumar K, Jiang Q et al. . A µ-opioid receptor modulator that works cooperatively with naloxone. (2024)   Nature , [Epub ahead of print]. [PMID: 38961287 ]
• Characterization of genetic variants of GIPR reveals a contribution of β-arrestin to metabolic phenotypes. Kizilkaya HS, Sørensen KV, Madsen JS, Lindquist P, Douros JD, Bork-Jensen J, Berghella A, Gerlach PA, Gasbjerg LS, Mokrosiński J et al. . Characterization of genetic variants of GIPR reveals a contribution of β-arrestin to metabolic phenotypes. (2024)   Nat Metab , [Epub ahead of print]. [PMID: 38871982 ]
• Liver ACOX1 regulates levels of circulating lipids that promote metabolic health through adipose remodeling. Lu D, He A, Tan M, Mrad M, El Daibani A, Hu D, Liu X, Kleiboeker B, Che T, Hsu FF et al. . Liver ACOX1 regulates levels of circulating lipids that promote metabolic health through adipose remodeling. (2024)   Nat Commun , 15 (1): 4214. [PMID: 38760332 ]
• The state of the art in secondary pharmacology and its impact on the safety of new medicines. Brennan RJ, Jenkinson S, Brown A, Delaunois A, Dumotier B, Pannirselvam M, Rao M, Ribeiro LR, Schmidt F, Sibony A et al. . The state of the art in secondary pharmacology and its impact on the safety of new medicines. (2024)   Nat Rev Drug Discov , [Epub ahead of print]. [PMID: 38773351 ]
• Molecular mechanism of choline and ethanolamine transport in humans. Ri K, Weng TH, Claveras Cabezudo A, Jösting W, Zhang Y, Bazzone A, Leong NCP, Welsch S, Doty RT, Gursu G et al. . Molecular mechanism of choline and ethanolamine transport in humans. (2024)   Nature , [Epub ahead of print]. [PMID: 38778100 ]
• Kainate receptor channel opening and gating mechanism. Gangwar SP, Yelshanskaya MV, Nadezhdin KD, Yen LY, Newton TP, Aktolun M, Kurnikova MG, Sobolevsky AI. Kainate receptor channel opening and gating mechanism. (2024)   Nature , [Epub ahead of print]. [PMID: 38778115 ]
• Distinct µ-opioid ensembles trigger positive and negative fentanyl reinforcement. Chaudun F, Python L, Liu Y, Hiver A, Cand J, Kieffer BL, Valjent E, Lüscher C. Distinct µ-opioid ensembles trigger positive and negative fentanyl reinforcement. (2024)   Nature , [Epub ahead of print]. [PMID: 38778097 ]
• Bitter taste TAS2R14 activation by intracellular tastants and cholesterol. Hu X, Ao W, Gao M, Wu L, Pei Y, Liu S, Wu Y, Zhao F, Sun Q, Liu J et al. . Bitter taste TAS2R14 activation by intracellular tastants and cholesterol. (2024)   Nature , [Epub ahead of print]. [PMID: 38776963 ]
• The microbial metabolite agmatine acts as an FXR agonist to promote polycystic ovary syndrome in female mice. Yun C, Yan S, Liao B, Ding Y, Qi X, Zhao M, Wang K, Zhuo Y, Nie Q, Ye C et al. . The microbial metabolite agmatine acts as an FXR agonist to promote polycystic ovary syndrome in female mice. (2024)   Nat Metab , [Epub ahead of print]. [PMID: 38769396 ]
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• Promoting gender equity in the scientific and health workforce is essential to improve women's health. Vieira Machado C, Araripe Ferreira C, de Souza Mendes Gomes MA. Promoting gender equity in the scientific and health workforce is essential to improve women's health. (2024)   Nat Med , [Epub ahead of print]. [PMID: 38519768 ]

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• Persistent complement dysregulation with signs of thromboinflammation in active Long Covid. Cervia-Hasler C, Brüningk SC, Hoch T, Fan B, Muzio G, Thompson RC, Ceglarek L, Meledin R, Westermann P, Emmenegger M et al. . Persistent complement dysregulation with signs of thromboinflammation in active Long Covid. (2024)   Science , 383 (6680): eadg7942. [PMID: 38236961 ]
• EPAC1 enhances brown fat growth and beige adipogenesis. Reverte-Salisa L, Siddig S, Hildebrand S, Yao X, Zurkovic J, Jaeckstein MY, Heeren J, Lezoualc'h F, Krahmer N, Pfeifer A. EPAC1 enhances brown fat growth and beige adipogenesis. (2024)   Nat Cell Biol , 26 (1): 113-123. [PMID: 38195707 ]
• Chemoproteomic development of SLC15A4 inhibitors with anti-inflammatory activity. Chiu TY, Lazar DC, Wang WW, Wozniak JM, Jadhav AM, Li W, Gazaniga N, Theofilopoulos AN, Teijaro JR, Parker CG. Chemoproteomic development of SLC15A4 inhibitors with anti-inflammatory activity. (2024)   Nat Chem Biol , [Epub ahead of print]. [PMID: 38191941 ]
• Insights for precision oncology from the integration of genomic and clinical data of 13,880 tumors from the 100,000 Genomes Cancer Programme. Sosinsky A, Ambrose J, Cross W, Turnbull C, Henderson S, Jones L, Hamblin A, Arumugam P, Chan G, Chubb D et al. . Insights for precision oncology from the integration of genomic and clinical data of 13,880 tumors from the 100,000 Genomes Cancer Programme. (2024)   Nat Med , 30 (1): 279-289. [PMID: 38200255 ]
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November 2023

• Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors. Boby ML, Fearon D, Ferla M, Filep M, Koekemoer L, Robinson MC, COVID Moonshot Consortium‡, Chodera JD, Lee AA, London N et al. . Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors. (2023)   Science , 382 (6671): eabo7201. [PMID: 37943932 ]

October 2023

• The IUPHAR/BPS Guide to PHARMACOLOGY in 2024. Harding SD, Armstrong JF, Faccenda E, Southan C, Alexander SPH, Davenport AP, Spedding M, Davies JA. The IUPHAR/BPS Guide to PHARMACOLOGY in 2024. (2024)   Nucleic Acids Res , 52 (D1): D1438-D1449. [PMID: 37897341 ]
• ADCdb: the database of antibody-drug conjugates. Shen L, Sun X, Chen Z, Guo Y, Shen Z, Song Y, Xin W, Ding H, Ma X, Xu W et al. . ADCdb: the database of antibody-drug conjugates. (2024)   Nucleic Acids Res , 52 (D1): D1097-D1109. [PMID: 37831118 ]
• TTD: Therapeutic Target Database describing target druggability information. Zhou Y, Zhang Y, Zhao D, Yu X, Shen X, Zhou Y, Wang S, Qiu Y, Chen Y, Zhu F. TTD: Therapeutic Target Database describing target druggability information. (2024)   Nucleic Acids Res , 52 (D1): D1465-D1477. [PMID: 37713619 ]
• Functional screening and rational design of compounds targeting GPR132 to treat diabetes. Wang JL, Dou XD, Cheng J, Gao MX, Xu GF, Ding W, Ding JH, Li Y, Wang SH, Ji ZW et al. . Functional screening and rational design of compounds targeting GPR132 to treat diabetes. (2023)   Nat Metab , 5 (10): 1726-1746. [PMID: 37770763 ]
• Genome-wide association analysis reveals insights into the molecular etiology underlying dilated cardiomyopathy. Zheng SL, Henry A, Cannie D, Lee M, Miller D, McGurk KA, Bond I, Xu X, Issa H, Francis C et al. . Genome-wide association analysis reveals insights into the molecular etiology underlying dilated cardiomyopathy. (2023)   medRxiv , Preprint. DOI: https://www.medrxiv.org/content/10.1101/2023.09.28.23295408v1
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Study reveals the benefits and downside of fasting

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Low-calorie diets and intermittent fasting have been shown to have numerous health benefits: They can delay the onset of some age-related diseases and lengthen lifespan, not only in humans but many other organisms.

Many complex mechanisms underlie this phenomenon. Previous work from MIT has shown that one way fasting exerts its beneficial effects is by boosting the regenerative abilities of intestinal stem cells, which helps the intestine recover from injuries or inflammation.

In a study of mice, MIT researchers have now identified the pathway that enables this enhanced regeneration, which is activated once the mice begin “refeeding” after the fast. They also found a downside to this regeneration: When cancerous mutations occurred during the regenerative period, the mice were more likely to develop early-stage intestinal tumors.

“Having more stem cell activity is good for regeneration, but too much of a good thing over time can have less favorable consequences,” says Omer Yilmaz, an MIT associate professor of biology, a member of MIT’s Koch Institute for Integrative Cancer Research, and the senior author of the new study.

Yilmaz adds that further studies are needed before forming any conclusion as to whether fasting has a similar effect in humans.

“We still have a lot to learn, but it is interesting that being in either the state of fasting or refeeding when exposure to mutagen occurs can have a profound impact on the likelihood of developing a cancer in these well-defined mouse models,” he says.

MIT postdocs Shinya Imada and Saleh Khawaled are the lead authors of the paper, which appears today in Nature .

Driving regeneration

For several years, Yilmaz’s lab has been investigating how fasting and low-calorie diets affect intestinal health. In a 2018 study , his team reported that during a fast, intestinal stem cells begin to use lipids as an energy source, instead of carbohydrates. They also showed that fasting led to a significant boost in stem cells’ regenerative ability.

However, unanswered questions remained: How does fasting trigger this boost in regenerative ability, and when does the regeneration begin?

“Since that paper, we’ve really been focused on understanding what is it about fasting that drives regeneration,” Yilmaz says. “Is it fasting itself that’s driving regeneration, or eating after the fast?”

In their new study, the researchers found that stem cell regeneration is suppressed during fasting but then surges during the refeeding period. The researchers followed three groups of mice — one that fasted for 24 hours, another one that fasted for 24 hours and then was allowed to eat whatever they wanted during a 24-hour refeeding period, and a control group that ate whatever they wanted throughout the experiment.

The researchers analyzed intestinal stem cells’ ability to proliferate at different time points and found that the stem cells showed the highest levels of proliferation at the end of the 24-hour refeeding period. These cells were also more proliferative than intestinal stem cells from mice that had not fasted at all.

“We think that fasting and refeeding represent two distinct states,” Imada says. “In the fasted state, the ability of cells to use lipids and fatty acids as an energy source enables them to survive when nutrients are low. And then it’s the postfast refeeding state that really drives the regeneration. When nutrients become available, these stem cells and progenitor cells activate programs that enable them to build cellular mass and repopulate the intestinal lining.”

Further studies revealed that these cells activate a cellular signaling pathway known as mTOR, which is involved in cell growth and metabolism. One of mTOR’s roles is to regulate the translation of messenger RNA into protein, so when it’s activated, cells produce more protein. This protein synthesis is essential for stem cells to proliferate.

The researchers showed that mTOR activation in these stem cells also led to production of large quantities of polyamines — small molecules that help cells to grow and divide.

“In the refed state, you’ve got more proliferation, and you need to build cellular mass. That requires more protein, to build new cells, and those stem cells go on to build more differentiated cells or specialized intestinal cell types that line the intestine,” Khawaled says.

Too much of a good thing

The researchers also found that when stem cells are in this highly regenerative state, they are more prone to become cancerous. Intestinal stem cells are among the most actively dividing cells in the body, as they help the lining of the intestine completely turn over every five to 10 days. Because they divide so frequently, these stem cells are the most common source of precancerous cells in the intestine.

In this study, the researchers discovered that if they turned on a cancer-causing gene in the mice during the refeeding stage, they were much more likely to develop precancerous polyps than if the gene was turned on during the fasting state. Cancer-linked mutations that occurred during the refeeding state were also much more likely to produce polyps than mutations that occurred in mice that did not undergo the cycle of fasting and refeeding.

“I want to emphasize that this was all done in mice, using very well-defined cancer mutations. In humans it’s going to be a much more complex state,” Yilmaz says. “But it does lead us to the following notion: Fasting is very healthy, but if you’re unlucky and you’re refeeding after a fasting, and you get exposed to a mutagen, like a charred steak or something, you might actually be increasing your chances of developing a lesion that can go on to give rise to cancer.”

Yilmaz also noted that the regenerative benefits of fasting could be significant for people who undergo radiation treatment, which can damage the intestinal lining, or other types of intestinal injury. His lab is now studying whether polyamine supplements could help to stimulate this kind of regeneration, without the need to fast.

“This fascinating study provides insights into the complex interplay between food consumption, stem cell biology, and cancer risk,” says Ophir Klein, a professor of medicine at the University of California at San Francisco and Cedars-Sinai Medical Center, who was not involved in the study. “Their work lays a foundation for testing polyamines as compounds that may augment intestinal repair after injuries, and it suggests that careful consideration is needed when planning diet-based strategies for regeneration to avoid increasing cancer risk.”

The research was funded, in part, by a Pew-Stewart Trust Scholar award, the Marble Center for Cancer Nanomedicine, the Koch Institute-Dana Farber/Harvard Cancer Center Bridge Project, and the MIT Stem Cell Initiative.

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Review of research on adverse childhood experiences identifies significant differences in size of effects

by Crime and Justice Research Alliance

Adverse childhood experiences (ACEs) significantly affect lifelong health and well-being. Despite extensive research on the topic, a wide-reaching understanding of ACEs' multifaceted impacts remains unrealized. In a new study, researchers have synthesized evidence from nearly 100 meta-analyses to provide a comprehensive view of ACEs' effects. They found significant differences in effect sizes depending on studies' approach, suggesting a critical need for a broad range of approaches to understand, prevent, and reduce the effects of ACEs.

The study, by researchers at Sam Houston State University (SHSU), appears in the Journal of Child Psychology and Psychiatry .

"The impacts of ACEs are heterogeneous and influenced by the type of adverse experience and the specific outcomes considered," according to Bitna Kim, professor of criminology and criminal justice at SHSU, who led the study. "Our findings highlight the complexity and varied nature of ACEs' influence on individual development and societal well-being, which has practical implications for public health and welfare."

ACEs encompass a spectrum of potentially traumatic events encountered from birth until age 17 as delineated by the U.S. Centers for Disease Control and Prevention, such as abuse, witnessing violence, and growing up in a family with mental health problems . Their overall prevalence is high, with about two in every five adults globally having experienced at least one ACE.

In the United States, more than 60% of adults have at least one ACE, with almost 17% enduring multiple ACEs. As a result, total annual costs attributable to ACEs in North America is estimated to be $748 billion, underscoring the financial burden on health and economic outcomes.

The field of research on ACEs is evolving rapidly, with hundreds of studies on diverse approaches to conceptualizing ACEs and their effects. In this context, maintaining a clear overview of the evidence has become increasingly challenging.

In this study, researchers used an umbrella synthesis method to integrate findings from 99 meta-analyses involving nearly 600 effect sizes. The study examined ACEs through four prevalent approaches: specificity (which examines the unique effects of individual adversities), lumping (which groups various adversities together), dimensional (which distinguishes between adversities while considering overarching dimensions), and child maltreatment-centric (which views abuse and neglect as interconnected elements).

Researchers assessed the impact of ACEs across six domains: biological system dysregulation, neuropsychological impairments, physical health complications, mental health conditions, social and behavioral challenges, and criminal justice involvement. Among the study's findings:

• Although the overarching effect size of ACEs on various outcomes is small to moderate, the true complexity and variability of their impact unfold only upon examining the interplay between the different approaches of measuring ACE and distinct outcomes.
• Specific approaches to studying ACEs yielded varying levels of impact, with notable differences in effects on mental health, social/behavioral issues, and criminal justice involvement.
• When ACEs were aggregated without distinguishing between different types but considering their cumulative effects, adverse outcomes were significantly exacerbated.
• The child maltreatment-centric approach consistently demonstrated substantial effects across all evaluated domains, including increased criminal justice involvement, more pronounced social and behavioral problems, and a range of mental health challenges.

The study's findings underscore the heterogeneity in ACEs' impacts, influenced by the type of ACE and specific outcomes considered. They also highlight the necessity for comprehensive approaches to understanding, preventing, and reducing the effects of ACEs.

"The insights we gleaned from our review highlight the pressing need for a shift in approach, moving beyond generic intervention models toward more sophisticated, coordinated, and multidisciplinary strategies that acknowledge the multifaceted nature of ACEs and their diverse impacts across different domains," says Meghan Royle, a doctoral student in criminology and criminal justice at SHSU, who co-authored the study.

"This requires a thorough reevaluation of current intervention strategies and policy frameworks to ensure they take into account the specific interactions between different ACEs and their varied developmental impacts."

For example, implementing ACE-informed practices across various settings should be paramount, so that individuals affected by ACEs receive consistent support in such settings as educational institutions, health care facilities , social care settings, and the criminal justice system. Prevention strategies are equally if not more important to alleviate the immediate impacts of ACEs and deter the long-term, complex challenges they present.

Among the study's limitations, the authors point out the difficulty of synthesizing the potential impact of research design on the effect sizes of the relationship between ACE approaches and outcomes. Given the methodological challenges, the authors propose a future ACE umbrella review agenda that addresses, among other foci, protective factors that shield children from the detrimental effects of adversity (e.g., stable and supportive relationships, resilience skills, positive school and community environments).

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Whether you want to treat disease, work in pharmacology, or be an environmental scientist, it all starts with a foundation in biological sciences. With a BA in this field, you’ll understand biology from the smallest cells to the biggest ecosystems and expand from there—exploring the ways those organisms interact with the world and the world with them.

With emphasis on real-world research and access to cutting-edge technology, you’ll reward your curiosity with a deep exploration of the topics that fascinate you most. There’s perhaps no better place to explore the natural world than the diverse habitats of Northern California. Whether bloodborne diseases in our on-campus labs or conducting wastewater surveys to test for viruses affecting our community, your academic experience will be enriched with an experience unlike any other and prepare you for the career of your dreams.

Intensive Science Curriculum

Your classes will include a thorough introduction to the physical sciences, anatomy, and molecular biology through a lens of critical thinking and hands-on research. In addition to an overview of basic biological principles, you’ll have the opportunity to study topics ranging from genetics and disease to hematology and ethics.

From Classroom to Career

A BA in Biological Sciences expertly prepares students who plan to use biology as a foundation for healthcare careers, such as pre-physician’s assistant, pre-nursing, or pre-occupational therapist. Many of our graduates also go on to the pharmaceutical industry, biomedical product management, and health regulatory positions

Some of our top recruiters:

• California Department of Fish and Wildlife
• North State hospitals and dental practices
• Sierra Nevada Brewing Co.

Proving It in the Field

Science isn’t a spectator sport. The best learning happens by doing, and at Chico State, you’ll study alongside faculty who have as much expertise outside the classroom as inside. By the time you graduate, you’ll have built the skills and confidence that only comes with experience.

Biology Student Research Symposium

Every spring, students gather to present their independent research in a poster tournament. Tackling topics from scoliosis to invasive insects and COVID-19 in wastewater, the best presentations are brought forward to compete at the University and possibly CSU level.

CSC2 Natural Sciences

Work alongside supportive faculty while taking your first steps in the lab in our CSC2 Natural Sciences program. Since 2016, this program has helped historically underserved students gain access to opportunities and support as they become adept at research. 

Searching for a Cure

Our faculty extend their expertise far beyond the classroom. With professors like Kristen Gorman, students are using Medaka fish to unravel the mysteries of idiopathic scoliosis (IS), a common abnormal spinal curvature condition in humans.

Get Involved

The best way to make friends and jumpstart your career? Join a student group. Get started by choosing from organizations like the Pre-Med Association, Pre-Dental Society, Microbiology Club, the Biology Honors Society, or the American Society for Microbiology. Then, join in the College of Natural Sciences Softball Tournament to build camaraderie!

Hands-On Happens Here

What you learn in the classroom is just part of the story. Whether you’re working in labs stocked with $1 million in industry-standard equipment like scanning electron, confocal, and fluorescence microscopes, or exploring collections of insects and animal specimens assembled over decades, you’ll put what you learn into practice every day.

Big Chico Creek Ecological Reserve

See conservation in action at this 7,835-acre reserve, which includes 4.5 miles of Big Chico Creek and a hundreds of animal and plant species. Research opportunities are as vast as your imagination.

Chico State Herbarium

The diversity of northeastern California’s plant life is here to explore at the herbarium, which contains more than 107,000 specimens—many of which are rare, threatened, or endangered.

Greenhouses

Explore the world of botany without leaving our greenhouses. The 6,000-square-foot research space contains over 1,500 plant species. Some are native to Chico, while others come from tropical or desert ecosystems across the globe.

Aquatic Bioassessment Lab

This lab monitors aquatic health by keeping tabs on the populations of water-based invertebrates in several areas around the state. Ongoing work includes data collection, research, and taxonomy. Bonus: Big Chico Creek is just 100 yards from your classroom!

Discover Stories and More

Biological Sciences Professor Immerses Students into Study of Rust-Producing Bacteria

Whether spending a year as a visiting scientist at one of the top microbiology programs in the world or publishing a paper in one of the globe’s leading microbiology journals, Emily Fleming is emerging as a scholar of note.

Alumnus in STEM Develops Life-Changing Medicines “To Improve Lives”

Scientist Kaniel Cassady discovered his knack for research conducting experiments in Big Chico Creek and now works as part of a global team developing medicines.

Poop Sleuths: Student Researchers Track COVID-19 in Residence Halls

Two biological sciences faculty and eight students are conducting complex wastewater monitoring in the residence halls to research the virus that causes COVID-19.

Pandemic-Themed Class Explores How Science and Society Tackle Germs

In “Pandemics, Germs, and Society,” students study vaccine science, information literacy, and how public health measures can restrict the spread of pathogens.

Related Programs

Biological sciences bs, biochemistry bs, microbiology bs, here's where it all starts. apply today., honoring the mechoopda people.

We acknowledge and are mindful that Chico State stands on lands that were originally occupied by the first people of this area, the Mechoopda, and we recognize their distinctive spiritual relationship with this land, the flora, the fauna, and the waters that run through campus. We are humbled that our campus resides upon sacred lands that since time immemorial have sustained the Mechoopda people and continue to do so today.

Working together, we can reimagine medicine to improve and extend people’s lives.

Principal Pharmacometrics Scientist

About the role.

Our Development Team is guided by our purpose: to reimagine medicine to improve and extend people’s lives.

To do this, we are optimizing and strengthening our processes and ways of working. 

We are investing in new technologies and building specific therapeutic area and platform depth and capabilities – all to bring our medicines to patients even faster.

We are seeking key talent, like you, to join us and help give people with disease and their families a brighter future to look forward to.

Apply today and welcome to where we thrive together!

As a Principal Pharmacometrics Scientist you will be responsible for the discussion and implementation of pharmacometrics methodologies that optimally address the research and development objectives on assigned projects.

This role offers hybrid working, requiring 3 days per week or 12 days per month in our London Office.

Key Accountabilities:

• You will lead the execution and delivery of pharmacometrics tasks on assigned projects within (early/full) clinical development.
• You will partner with Novartis Institute for Biomedical Research, Pharmacometrics Development Unit leader and senior pharmacometrics associates to negotiate and develop pharmacometrics objectives and deliverables.
• You will partner with colleagues in (early/full) Global Project Teams providing pharmacometrics support for the quantitative evaluation of competing trial/analysis strategies assuring robust support to clinical development planning and execution and alignment with clinical development plans and target product profiles.
• You will collaborate closely with the Analytics team (biometrician, data management, database programming, programming, medical and scientific writing) on the pharmacometrics strategy and execution on assigned projects.
• You will contribute to the pharmacometrics scientific content of materials for internal decision boards/regulatory/submission documents: Briefing Books, decision criteria, trial design(s), responses to trial-specific Health Authority questions.
• You will promote the use of innovative methods within the organization, through scientific collaborations, publications in scientific peer reviewed journals and presentations at professional meetings.

Your Experience

• Ph.D. in pharmacology, biology, engineering, mathematics, statistics, or a field with significant modeling-related content (or equivalent).
• More than 2 years’ experience in modeling related activity relevant to the role as a pharmacometrician.
• Sound knowledge with SAS / R / MATLAB / NONMEM / Monolix or any other business or research analytic software relevant to pharmacometrics.
• scientific leadership skills demonstrated in facilitating the inclusion and execution of pharmacometrics methods.

Why Novartis:  Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future  together? : https://www.novartis.com/about/strategy/people-and-culture

Commitment to Diversity & Inclusion :

Novartis is committed to building an outstanding, inclusive work environment and diverse team’s representative of the patients and communities we serve.

Join our Novartis Network:

Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network  

Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture

Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network

Novartis is committed to building an outstanding, inclusive work environment and diverse teams' representative of the patients and communities we serve.