= 204,723
ADHD, attention-deficit/hyperactivity disorder; SD, standard deviation
† Indicates standardized differences > 0.10
a The ADHD+anxiety/depression cohort comprised patients with ADHD+only anxiety, ADHD+only depression, and ADHD+both anxiety and depression
b A standardized difference of < 0.10 was considered as well balanced
c In both cohorts, ≤ 0.1% reported “Unknown”
d Based on American Psychiatric Pub (2022). Diagnostic and Statistical Manual of Mental Disorders (DSM-5-TR®)
e Based on Elixhauser A, Steiner C, Kruzikas. D. HCUP Comorbidity Software. Healthcare Cost and Utilization Project (HCUP). October 2015. Agency for Healthcare Research and Quality, Rockville, MD. Available from: https://www.hcup-us.ahrq.gov/toolssoftware/comorbidity/comorbidity.jsp#download
f Includes the following conditions: gangliosidosis/sphingolipidosis, systemic atrophies primarily affecting the central nervous system (i.e., Huntington’s), extrapyramidal and movement disorders (i.e., Parkinson’s), other degenerative diseases of the nervous system (i.e., Alzheimer’s), demyelinating diseases of the central nervous system (i.e., multiple sclerosis), episodic and paroxysmal disorders (i.e., epilepsy and seizures), cerebral palsy, and hydrocephalus
g Categories are not mutually exclusive
h Calculated among those with ≥ 1 visit
Although the majority of patients received stimulants as the index treatment in both cohorts, the proportion of patients who received non-stimulants was observed to be numerically higher in the ADHD+anxiety/depression cohort (22.7%) than in the ADHD-only cohort (10.2%); similar trends were observed during the baseline period (Table 1 ). Furthermore, more patients in the ADHD+anxiety/depression cohort than the ADHD-only cohort received antianxiety agents or antidepressants, or had psychotherapy or specialist visits, during the baseline period.
During the study period, rates of all-cause HRU were significantly higher in the ADHD+anxiety/depression cohort than in the ADHD-only cohort, with an incidence rate ratio of 10.3 for inpatient admissions, 1.6 for emergency room visits, 2.3 for outpatient visits, 5.3 for specialist visits, and 6.1 for psychotherapy visits (all p < 0.001; Fig. 1 ).
All-cause HRU during the 12-month study period a . ADHD, attention-deficit/hyperactivity disorder; CI, confidence interval; IR, incidence rate; IRR, incidence rate ratio; PPPY, per-patient-per-year. * Statistically significant at the 0.1% level . a The ADHD+anxiety/depression cohort comprised patients with ADHD+only anxiety, ADHD+only depression, and ADHD+both anxiety and depression
Compared with the ADHD-only cohort, the mean all-cause healthcare costs PPPY were more than twice as high in the ADHD+anxiety/depression cohort ($3,988 vs. $8,682; mean difference: $4,695), driven by differences in both medical and pharmacy costs (all p < 0.001; Fig. 2 ).
All-cause healthcare costs during the 12-month study period a . ADHD, attention-deficit/hyperactivity disorder; MD, mean difference; PPPY, per-patient-per-year; USD, United States dollar. * Statistically significantly different than the ADHD-only cohort at the 0.1% level . a The ADHD+anxiety/depression cohort comprised patients with ADHD+only anxiety, ADHD+only depression, and ADHD+both anxiety and depression
Among the subgroups of patients with ADHD, the mean all-cause healthcare costs PPPY were $7,309 among those who had only anxiety, $9,901 among those who had only depression, and $13,785 among those who had both anxiety and depression (all p < 0.001; Fig. 3 ), translating to 1.8, 2.5, and 3.5 times higher excess healthcare costs compared with those who had ADHD only.
All-cause healthcare costs during the 12-month study period– subgroup analysis. ADHD, attention-deficit/hyperactivity disorder; MD, mean difference; PPPY, per-patient-per-year; USD, United States dollar. * Statistically significantly different than the ADHD-only cohort at the 0.1% level
The current case-cohort analysis found that relative to pediatric patients with ADHD only, those with ADHD and comorbid anxiety and/or depression were 10 times more likely to be hospitalized and 5–6 times more likely to have a specialist or psychotherapy visit. Furthermore, pediatric patients with ADHD and comorbid anxiety and/or depression incurred more than twice the healthcare costs of those without the comorbidities, with a mean difference of $4,695 PPPY. Notably, the excess healthcare cost further increased among those with both comorbid anxiety and depression, with the total cost being 3.5 times higher than those with ADHD only. Together, these findings underscore the substantial excess HRU and cost burden imposed by comorbid anxiety and depression among pediatric patients with ADHD. The excess per-patient costs associated with these comorbidities could amount to an enormous expenditure for payers. For example, in a hypothetical health plan of 100,000 lives (with 50,000 children and adolescents, respectively), the excess healthcare cost of $4,695 PPPY could amount to $7.1 million per year incremental to the cost burden associated with ADHD alone (Fig. 4 ). Sensitivity analyses varying ADHD prevalence estimates suggest that the incremental healthcare cost of comorbid anxiety and depression relative to ADHD alone in a hypothetical health plan of 100,000 lives could range from $2.9 to $10.6 million per year assuming an ADHD prevalence of 3.4–11.1% for children and 3.4–13.6% for adolescents [ 3 – 8 ].
Incremental cost of comorbid anxiety and/or depression in ADHD relative to ADHD alone in a simulated health plan. ADHD, attention-deficit/hyperactivity disorder; FDA, Food and Drug Administration; US, United States. a A hypothetical value. b Based on the National Survey of Children’s Health data, 2018 [ 2 ]. c Based on Kessler et al., 2012 [ 3 ]. d Based on results in the current study
Findings of the current study are generally similar to a previous study among adults with ADHD, which found that comorbid anxiety and/or depression, especially when presented together, contributed to significant excess HRU and healthcare costs [ 27 ]. It has been previously shown that patients with ADHD who have comorbid anxiety and/or depression exhibit higher odds of treatment changes and incur higher associated costs relative to those with ADHD only [ 19 ], which may have partially contributed to the poorer clinical and economic outcomes among those with the comorbidities observed in the current study. It was also noted that treatment characteristics appear to be different among the pediatric and adult populations: a numerically higher proportion of pediatric patients received non-stimulants when anxiety and/or depression were present relative to adults with these comorbidities (22.7% vs. 6.8% at index; 21.1% vs. 5.3% during baseline) [ 27 ]. This may be due to some physicians being more cautious when considering stimulants for at-risk pediatric patients with comorbid emotional or behavioral conditions given the potential side effects of some medications on mood and emotion symptoms, despite their effectiveness [ 1 ]. Collectively, these observations highlight the need for improved management and treatment options to alleviate the burden associated with comorbidities in ADHD [ 28 ].
The current findings are also in line with the literature on HRU and economic burden of comorbidities among pediatric patients with ADHD [ 18 , 29 , 30 ]. A prior large US national survey reported that a higher proportion of pediatric patients with ADHD and comorbid emotional disturbances and depression, respectively, were hospitalized compared with those with the comorbidity only, and inpatient costs tended to be higher with the presence of both ADHD and the comorbidity [ 30 ]. Another US national survey found significantly greater odds of HRU (i.e., having ≥ 6 healthcare provider visits; ≥2 emergency room visits) among pediatric patients with ADHD and comorbid anxiety and depression, respectively [ 29 ]. Relative to the previous studies, the current study comprises more comprehensive HRU and cost categories, which provides insight on the overall clinical and economic burden attributable to anxiety and depression among those with ADHD. Furthermore, cost analyses among comorbidity subgroups also quantify the substantial impact to the healthcare system when both comorbid anxiety and depression are present in ADHD. Future studies investigating the impact of other psychiatric comorbidities on outcomes of pediatric patients with ADHD are warranted.
Managing ADHD and psychiatric comorbidities early in pediatric patients with ADHD may mitigate their burden in both the short-term and longer-term. In the short-term, reduced hospitalizations and psychotherapy visits may lead to less missed school days and better academic performances [ 31 ]. In the longer-term, certain childhood comorbidities, including anxiety and depression, have been shown to predict the development of other psychiatric comorbidities in later life [ 32 ]; therefore, a larger ADHD population may be affected by the impact of psychiatric comorbidities if the ADHD and its comorbid symptoms are not managed early. Indeed, the prevalence of comorbid anxiety and depression in ADHD appears to increase with age from childhood to adulthood [ 18 , 19 , 33 ]. In US population-based surveys, comorbid anxiety and depression have been reported in about 20% of pediatric patients with ADHD [ 18 ]; among adults, the prevalence of these comorbidities is up to 50% [ 33 ]. The respective prevalence of ADHD, anxiety, and depression have also been increasing in the US over the years, particularly among youths [ 34 , 35 ], highlighting the urgency in addressing these psychiatric conditions at earlier stages to prevent their subsequent negative consequences in wider populations.
Findings of this study may help raise awareness to various stakeholders on the magnitude of the excess burden imposed by psychiatric comorbidities on pediatric patients with ADHD. For instance, parents and teachers may pay more attention to the emotional well-being of children and adolescents with ADHD and provide them with needed support to ease their anxiety or depression; clinicians may be more vigilant in considering the impact of psychiatric comorbidities in their ADHD management plan; and research efforts may be directed to exploring medications effective for improving both ADHD and comorbid psychiatric symptoms. These and other strategies may help alleviate the substantial burden associated with psychiatric comorbidities imposed on pediatric patients with ADHD and on the healthcare system at large.
This study is subject to limitations inherent to retrospective databases using claims data, including potential data omissions, coding errors, and the presence of rule-out diagnosis (i.e., a record of an ADHD, an anxiety, or a depression diagnosis does not necessarily indicate that the patient has a true diagnosis). In addition, while cohorts were balanced based on observable characteristics, there may be residual confounding due to unobservable confounders; therefore, no causal inference can be made from this retrospective observational study. It should also be noted that the burden associated with anxiety and depression goes beyond HRU and healthcare costs, but this study was limited to information available in claims data; future research is warranted to explore other types of burden associated with comorbid anxiety and depression in ADHD. Finally, this study included only commercially insured patients and may not be representative of the pediatric population with ADHD in the US.
Comorbid anxiety and depression were associated with significantly increased risk of HRU and higher healthcare costs among pediatric patients with ADHD. In particular, the presence of both comorbid conditions resulted in 3.5 times higher excess costs relative to ADHD alone. Increased awareness of such burden and strategies to co-manage ADHD and psychiatric comorbidities are warranted to help mitigate the burden borne by patients and the healthcare system.
Below is the link to the electronic supplementary material.
Medical writing assistance was provided by Flora Chik, PhD, MWC an employee of Analysis Group, Inc. and funded by Otsuka Pharmaceutical Development & Commercialization, Inc.
AMCP | Academy of Managed Care Pharmacy |
FDA | Food and Drug Administration |
HCUP | Healthcare Cost and Utilization Project |
HIPAA | Health Insurance Portability and Accountability Act |
HRSA | Health Resources and Services Administration |
HRU | Healthcare resource utilization |
NSCH | National Survey of Children’s Health |
PPPY | Per-patient-per-year |
SD | Standard deviation |
US | United States |
USD | United States dollar |
MC, MGL, RB, KC, DC, and AG contributed to study conception and design, collection and assembly of data, and data analysis and interpretation. JS and AC contributed to study conception and design, data analysis and interpretation. All authors reviewed and approved the final content of this manuscript.
This study was funded by Otsuka Pharmaceutical Development & Commercialization, Inc. The study sponsor was involved in several aspects of the research, including the study design, interpretation of data, writing of the manuscript, and decision to submit the manuscript for publication.
Declarations.
Data analyzed in this study are de-identified and comply with the patient requirements of the Health Insurance Portability and Accountability Act (HIPAA); therefore, no review by an institutional review board nor informed consent was required per Title 45 of CFR, Part 46.101(b)(4) [ 23 ].
Not applicable.
JS is an employee of Otsuka Pharmaceutical Development & Commercialization, Inc. MC, MGL, RB, KC, DC, and AG are employees of Analysis Group, Inc., a consulting company that has provided paid consulting services to Otsuka Pharmaceutical Development & Commercialization, Inc. AC received research support from Allergan, Takeda/Shire, Emalex, Akili, Ironshore, Arbor, Aevi Genomic Medicine, Neos Therapeutics, Otsuka, Pfizer, Purdue, Rhodes, Sunovion, Tris, KemPharm, Supernus, and the U.S. Food and Drug Administration; was on the advisory board of Takeda/Shire, Akili, Arbor, Cingulate, Ironshore, Neos Therapeutics, Otsuka, Pfizer, Purdue, Adlon, Rhodes, Sunovion, Tris, Supernus, and Corium; received consulting fees from Arbor, Ironshore, Neos Therapeutics, Purdue, Rhodes, Sunovion, Tris, KemPharm, Supernus, Corium, Jazz, Tulex Pharma, and Lumos Pharma; received speaker fees from Takeda/Shire, Arbor, Ironshore, Neos Therapeutics, Pfizer, Tris, and Supernus; and received writing support from Takeda /Shire, Arbor, Ironshore, Neos Therapeutics, Pfizer, Purdue, Rhodes, Sunovion, and Tris.
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Mycelium-based leather is a leather-like material composed of filamentous, branched, and fibrous vegetative parts of fungi, specifically fungal mycelium. This study aimed to assess the production process of mycelium-based leather in Indonesia, especially in the Mylea™ manufacturing process, by considering its environmental impact through a life cycle assessment.
The scope of the study starts from the cradle where mycelium is cultivated to the gate of the leather process. A functional unit of 1 m 2 natural Mylea™ grade A was used as a reference. The inventory of mycelia as foreground data was gathered from the Indonesian factory with supporting data taken from relevant literature. The infrastructure is not included within the system boundaries. The ISO 14040 and 14044 standards were followed during the analysis. This study used the software OpenLCA 2.02 to carry out the impact assessment and used the Ecoinvent database v3.8. The life cycle impact assessment (LCIA) was carried out using the CML-IA baseline method with 11 impact categories. A sensitivity and uncertainty analysis were conducted to evaluate the environmental impact.
The finishing process is the main contributor to all the environmental impact categories. The LCIA results revealed that 1 m 2 of natural Mylea™ grade A produces 57.15 kg of CO 2 eq. Energy usage in the form of electricity consumption is the major cause, contributing 46.53 kg of CO 2 eq to the total carbon footprint, followed by cotton at 6.67 kg of CO 2 eq and (ethylene–vinyl acetate) EVA glue at 1.03 kg of CO 2 eq. The finishing process, which uses cotton fabric, emerged as the primary environmental hotspot, contributing significantly to most impact categories, such as terrestrial ecotoxicity potential (TEP), abiotic depletion potential (ADP), and global warming potential (GWP100a). Alternative energy scenarios, including hydropower and solar energy, were examined, revealing their potential to reduce the environmental impact.
The environmental impacts of mycelium-based leather production were identified in 11 categories. According to the findings, the most critical input parameter is the use of electricity sources. Therefore, several alternative energy sources, such as hydropower and solar photovoltaics, have been proposed to reduce environmental impacts.
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The authors would like to acknowledge Mycotech Lab (MYCL) Indonesia for providing the data used in this research.
The authors are thankful for financial support from the National Research and Innovation Agency of Indonesia.
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Hismiaty Bahua, Sri Peni Wijayanti, Agusta Samodra Putra, Nadia Rizki Ariyani, Febrian Isharyadi, Nuha Nuha, Ari Kabul Paminto, Mulyono Mulyono, Ira Nurhayati Djarot, Netty Widyastuti, Amita Indah Sitomurni, Arief Ameir Rahman Setiawan & Titin Handayani
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All the authors contributed to the study concept, idea, and design. IND, NW, and MM prepared the materials and collected the data. HB, SPW, NRA, FI, and ASP conducted the literature, data analysis, and writing of the manuscript. NN and AIS conducted the data handling and administration. AARS and ASP participated in critically analyzing the manuscript for significant intellectual content. IND, TH, and NW participated in the conceptualization of the study. HB, SPW, AKP, and FI wrote the first draft of the manuscript, and all authors commented on previous versions. All the authors have read and approved the final manuscript.
Correspondence to Sri Peni Wijayanti .
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Bahua, H., Wijayanti, S.P., Putra, A.S. et al. Life cycle assessment (LCA) of leather-like materials from mycelium: Indonesian case study. Int J Life Cycle Assess (2024). https://doi.org/10.1007/s11367-024-02351-5
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DOI : https://doi.org/10.1007/s11367-024-02351-5
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A case study is a detailed study of a specific subject, such as a person, group, place, event, organization, or phenomenon. Case studies are commonly used in social, educational, clinical, and business research. A case study research design usually involves qualitative methods, but quantitative methods are sometimes also used.
The purpose of case study research is twofold: (1) to provide descriptive information and (2) to suggest theoretical relevance. Rich description enables an in-depth or sharpened understanding of the case. It is unique given one characteristic: case studies draw from more than one data source. Case studies are inherently multimodal or mixed ...
A case study is a research method that involves an in-depth examination and analysis of a particular phenomenon or case, such as an individual, organization, community, event, or situation. It is a qualitative research approach that aims to provide a detailed and comprehensive understanding of the case being studied. Case studies typically ...
A case study protocol outlines the procedures and general rules to be followed during the case study. This includes the data collection methods to be used, the sources of data, and the procedures for analysis. Having a detailed case study protocol ensures consistency and reliability in the study.
A case study is one of the most commonly used methodologies of social research. This article attempts to look into the various dimensions of a case study research strategy, the different epistemological strands which determine the particular case study type and approach adopted in the field, discusses the factors which can enhance the effectiveness of a case study research, and the debate ...
Case study method is the most widely used method in academia for researchers interested in qualitative research (Baskarada, 2014). Research students select the case study as a method without understanding array of factors that can affect the outcome of their research.
Definition, Methods, and Examples. Case study methodology offers researchers an exciting opportunity to explore intricate phenomena within specific contexts using a wide range of data sources and collection methods. It is highly pertinent in health and social sciences, environmental studies, social work, education, and business studies.
A case study is a detailed study of a specific subject, such as a person, group, place, event, organisation, or phenomenon. Case studies are commonly used in social, educational, clinical, and business research. A case study research design usually involves qualitative methods, but quantitative methods are sometimes also used.
A case study is an in-depth analysis of one individual or group. Learn more about how to write a case study, including tips and examples, and its importance in psychology. ... Interviews: Interviews are one of the most important methods for gathering information in case studies. An interview can involve structured survey questions or more open ...
Qualitative case study methodology provides tools for researchers to study complex phenomena within their contexts. When the approach is applied correctly, it becomes a valuable method for health ...
Case studies are in-depth investigations of a person, group, event, or community. Typically, data is gathered from various sources using several methods (e.g., observations & interviews). The case study research method originated in clinical medicine (the case history, i.e., the patient's personal history). In psychology, case studies are ...
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Purpose of case study methodology. Case study methodology is often used to develop an in-depth, holistic understanding of a specific phenomenon within a specified context. 11 It focuses on studying one or multiple cases over time and uses an in-depth analysis of multiple information sources. 16,17 It is ideal for situations including, but not limited to, exploring under-researched and real ...
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A case study is a research approach that is used to generate an in-depth, multi-faceted understanding of a complex issue in its real-life context. It is an established research design that is used extensively in a wide variety of disciplines, particularly in the social sciences. A case study can be defined in a variety of ways (Table 5 ), the ...
Definitions of qualitative case study research. Case study research is an investigation and analysis of a single or collective case, intended to capture the complexity of the object of study (Stake, 1995).Qualitative case study research, as described by Stake (), draws together "naturalistic, holistic, ethnographic, phenomenological, and biographic research methods" in a bricoleur design ...
Researchers, economists, and others frequently use case studies to answer questions across a wide spectrum of disciplines, from analyzing decades of climate data for conservation efforts to developing new theoretical frameworks in psychology. Learn about the different types of case studies, their benefits, and examples of successful case studies.
Through the case method, you can "try on" roles you may not have considered and feel more prepared to change or advance your career. 5. Build Your Self-Confidence. Finally, learning through the case study method can build your confidence. Each time you assume a business leader's perspective, aim to solve a new challenge, and express and ...
A case study is a research process aimed at learning about a subject, an event or an organization. Case studies are use in business, the social sciences and healthcare. A case study may focus on one observation or many. It can also examine a series of events or a single case. An effective case study tells a story and provides a conclusion.
Advantages. 1. In-depth analysis of complex phenomena. Case study design allows researchers to delve deeply into intricate issues and situations. By focusing on a specific instance or event, researchers can uncover nuanced details and layers of understanding that might be missed with other research methods, especially large-scale survey studies.
The case method is a teaching approach that uses decision-forcing cases to put students in the role of people who were faced with difficult decisions ... The Case Centre is the world's largest and most diverse repository of case studies used in Management Education, with cases from the world's top case publishing schools, including ...
Case Method in Practice. Chris Christensen described case method teaching as "the art of managing uncertainty"—a process in which the instructor serves as "planner, host, moderator, devil's advocate, fellow-student, and judge," all in search of solutions to real-world problems and challenges. Unlike lectures, case method classes unfold ...
A case study is an in-depth, detailed examination of a particular case (or cases) within a real-world context. For example, case studies in medicine may focus on an individual patient or ailment; case studies in business might cover a particular firm's strategy or a broader market; similarly, case studies in politics can range from a narrow happening over time like the operations of a specific ...
Assessing healthy cities is a crucial strategy for realizing the concept of "health in all policies". However, most current quantitative assessment methods for healthy cities are predominantly city-level and often overlook intra-urban evaluations. Building on the concept of geographic spatial case-based reasoning (CBR), we present an innovative healthy city spatial case-based reasoning ...
Rational Approach For Vaccinating Case Study 474 Words 2 Pages When manager are faced with a situation with insufficient time for a thoughtful process, they use a rational decision making method to formulate a solution (Borkowski , 2016, pp. 289).
This study used a retrospective case-cohort design . The index date was defined as the date of initiation of a randomly selected US Food and Drug Administration (FDA)-approved agent for the treatment of ADHD that was newly initiated after the first ADHD diagnosis; this definition allowed capturing of patients at different stages of their ADHD ...
Universities can make a significant contribution to sustainability, and the development of sustainability competences in their graduates should be a key outcome of their courses. We propose an assessment framework for enabling and evaluating the attainment of sustainability competences in University students. We outline its six steps, offering tools on how to assess the alignment of University ...
Purpose Mycelium-based leather is a leather-like material composed of filamentous, branched, and fibrous vegetative parts of fungi, specifically fungal mycelium. This study aimed to assess the production process of mycelium-based leather in Indonesia, especially in the Mylea™ manufacturing process, by considering its environmental impact through a life cycle assessment. Method The scope of ...