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Types of Positions Include:

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DHHS, NIH and NCI are equal opportunity employers . The NCI and CCR are deeply committed to diversity of thought, equity and inclusion and encourage applications from qualified women, underrepresented minorities and individuals with disabilities.

Why Choose CCR?

Learn more about why CCR is a great place to work.

Meet Our People

Trish Beard

Trish Beard

Managers here support career advancement and a healthy balance of work and family.

Deborah Citrin

Deb Citrin, M.D.

Working at the CCR provides me an opportunity to make a difference in the daily lives of cancer patients in a way that would not be possible anywhere else.

Freddy Escorcia, M.D., Ph.D.

Freddy Escorcia, M.D., Ph.D.

CCR offers a unique collaborative environment with the resources and scientific freedom to fully exploit emerging technologies, ultimately effecting change for patients with cancer.

Fatima Karzai, M.D.

Fatima Karzai, M.D.

I can collaborate and bring new ideas into clinical trials to treat patients. A career here gives me the opportunity to fulfill my scientific curiosity. 

Sam John, Ph.D.

Sam John, Ph.D.

CCR provides an unfailingly nurturing, supportive and scientifically engaging ecosystem that is extremely fulfilling and rewarding to investigators in all stages of their scientific careers.

Jason Levine, M.D.

Jason Levine, M.D.

This place is filled with passionate people who are focusing all their energy on curing cancer.

Yolanda McKinney, B.S.N.

Yolanda McKinney, B.S.N.

It’s nice to know that your work is occurring side-by-side with scientists and it’s translating into patient care.

Ira Pastan, M.D.

Ira Pastan, M.D.

The attractiveness of working at NIH is you are free to follow your instincts to do high risk research that could be very productive and make your own decisions. You have wonderful colleagues and a wonderful working environment.

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Found 19 Faculty jobs

Tenure track/tenured faculty position in cancer research.

Case Western Reserve University  logo

  • Cleveland, Ohio (US)
  • Commensurate with experience
  • Case Western Reserve University

Inviting applications for tenure track/tenured faculty positions at the rank of Assistant, Associate, or Full Professor.

View details TENURE TRACK/TENURED FACULTY POSITION IN CANCER RESEARCH

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Open-Rank Faculty Position, Cancer Prevention and Control (CPC) Research Program

University of Rochester- Wilmot Cancer Institute logo

  • Rochester, New York
  • Academic rank and salary commensurate with qualifications and experience.
  • University of Rochester- Wilmot Cancer Institute

The Cancer Prevention and Control (CPC) Research Program within University of Rochester Wilmot Cancer Institute (WCI) invites candidates to apply f...

View details Open-Rank Faculty Position, Cancer Prevention and Control (CPC) Research Program

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Post-Doctoral Fellow, Associate Research Scholar, Staff Scientist: Cell signaling, Cell movement

University of Oklahoma Health Sciences Center logo

  • Oklahoma City, Oklahoma
  • Salary to be commensurate with experience
  • University of Oklahoma Health Sciences Center

Post-Doctoral Fellow, Associate Research Scholar or Staff Scientist positions to study cell signaling, cell movement, and colon cancer

View details Post-Doctoral Fellow, Associate Research Scholar, Staff Scientist: Cell signaling, Cell movement

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Assistant/Associate Professor-Molecular Pharmacology

Albert Einstein College of Medicine logo

  • Bronx, New York
  • $130,000 to $160,000
  • Albert Einstein College of Medicine

The Department of Molecular Pharmacology is seeking candidates for a tenure-track position in cancer metabolism.

View details Assistant/Associate Professor-Molecular Pharmacology

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Assistant Professor or Higher

Texas Tech University Health Sciences Center El Paso -Department of Molecular and Translational Medicine  logo

  • El Paso, Texas
  • Compensation is commensurate upon the qualifications
  • Texas Tech University Health Sciences Center El Paso -Department of Molecular and Translational Medicine

Assistant Professor or Higher Department of Molecular and Translational Medicine Center of Emphasis in Cancer   The Department of Molecular and Tra...

View details Assistant Professor or Higher

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Texas Tech University Health Sciences Center El Paso -Department of Molecular and Translational Medicine  logo

Assistant Professor or Higher Department of Molecular and Translational Medicine Center of Emphasis in Cancer  The Department of Molecular and Tran...

Professor and Director, of the Institute for Cancer Genetics

The Vagelos College of Physicians and Surgeons and Herbert Irving Comprehensive Cancer Center logo

  • New York City, New York (US)
  • $370,000 - $450,000
  • The Vagelos College of Physicians and Surgeons and Herbert Irving Comprehensive Cancer Center

The Vagelos College of Physicians and Surgeons & Herbert Irving Comprehensive Cancer Center is seeking a Director of the Institute for Cancer Genetics

View details Professor and Director, of the Institute for Cancer Genetics

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Genitourinary Oncology, Assistant to Associate Member

Roswell Park Comprehensive Cancer Center logo

  • Buffalo, New York
  • Commensurate with education and experience
  • Roswell Park Comprehensive Cancer Center

GU-ORC is seeking to expand the scope of its laboratory based scientific research in areas broadly relevant to GU cancers.

View details Genitourinary Oncology, Assistant to Associate Member

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Assistant Professor (tenure-track)

Rosalind Franklin University of Medicine and Sciences logo

  • Center for Genetic Diseases, Chicago Medical School, Rosalind Franklin Univ, North Chicago, Illinois
  • competitive
  • Rosalind Franklin University of Medicine and Sciences

Tenure-track 12-month Assistant Professor position in Chicago Medical School RFUMS in North Chicago

View details Assistant Professor (tenure-track)

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Assistant Professor/Assistant Member in the Department of Cancer Genetics and Genomics

Roswell Park Comprehensive Cancer Center  logo

  • Buffalo, New York (US)
  • $98,456 - $212,380

Roswell Park Comprehensive Cancer Center is seeking to expand our exceptional research programs in Cancer Genetics and Genomics. Roswell Park is Am...

View details Assistant Professor/Assistant Member in the Department of Cancer Genetics and Genomics

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Tenure Track Faculty Positions in Cancer

Augusta University logo

  • Augusta, Georgia (US)
  • See job description.
  • Augusta University

Tenure Track Faculty Positions in Cancer Augusta University Georgia Cancer Center (GCC) at Augusta University is seeking applications for fa

View details Tenure Track Faculty Positions in Cancer

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Assistant Professor of Immunology

  • Boston, Massachusetts (US)
  • Dana-Farber Cancer Institute

Dana-Farber Cancer Institute and the Department of Immunology at Harvard Medical School invite applications for a tenure-track faculty position

View details Assistant Professor of Immunology

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CHAIR Department of Radiation Oncology

Northwestern University Feinberg School of Medicine  logo

  • Chicago, Illinois
  • Northwestern University Feinberg School of Medicine

Invites applications and nominations for the position of Chair of the Department of Radiation Oncology.

View details CHAIR Department of Radiation Oncology

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Assistant Professor- Developmental Therapeutics

  • Texas Tech University Health Sciences Center, SOM, Cancer Center, Lubbock, TX
  • Rank and salary are dependent upon qualifications and experience.
  • TTUHSC Cancer Research Center

Asst Professor level tenure-track position in pediatric cancer developmental therapeutics. Preference given to pediatric oncology physician-scientists

View details Assistant Professor- Developmental Therapeutics

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Basic Sciences Faculty - Cancer Biology Program

Massey Comprehensive Cancer Center Virginia Commonwealth University logo

  • Richmond, Virginia (US)
  • Massey Comprehensive Cancer Center Virginia Commonwealth University

These faculty positions are at the rank of Assistant, Associate or Full Professor and could be tenure-eligible for qualified candidates.

View details Basic Sciences Faculty - Cancer Biology Program

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Faculty Positions – Assistant, Associate and Full Professor

Miami Miller School of Medicine - Desai Sethi Urology and Sylvester Comprehensive Cancer Center logo

  • Miami, Florida
  • The University of Miami offers competitive salaries and a comprehensive benefits package.
  • Miami Miller School of Medicine - Desai Sethi Urology and Sylvester Comprehensive Cancer Center

Seeking outstanding scientists for faculty positions at the assistant through full professor levels with experience in genitourinary cancers.

View details Faculty Positions – Assistant, Associate and Full Professor

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TENURED/TENURE TRACK FACULTY POSITIONS in GENETICS/GENOMICS

Baylor College of Medicine logo

  • Houston, Texas (US)
  • Baylor College of Medicine

DEPARTMENT OF MOLECULAR AND HUMAN GENETICS AND DAN L. DUNCAN COMPREHENSIVE CANCER CENTER

View details TENURED/TENURE TRACK FACULTY POSITIONS in GENETICS/GENOMICS

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Faculty-Department of Biochemistry

  • Charleston, South Carolina
  • Medical University of South Carolina.

The Department of Biochemistry is inviting applications for faculty positions at the Assistant, Associate, and Full Professor level.

View details Faculty-Department of Biochemistry

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Assistant Scientist/Professor Position, Sanford Research

Sanford Research logo

  • Sioux Falls, South Dakota
  • Sanford Research

Assistant Scientist/Professor Positions, Sanford Research Sanford Research invites applications for full-time faculty at the rank of Assistant Scie...

View details Assistant Scientist/Professor Position, Sanford Research

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MD Anderson Cancer Center

Research assistant i – gu medical oncology md anderson cancer center.

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The Wang lab at MD Anderson Cancer Center is seeking a highly motivated Research Assistant I who is interested in basic and translational cancer research which are supported by NIH/NCI and Department of Defense Prostate Cancer Research Program and Kidney Cancer Research Program. The job duties involve mouse breeding , various in vivo experiments using mice, and molecular/cellular benchwork.

https://gsbs.uth.edu/directory/profile?id=08b937c4-46a2-4162-b61b-698054cf3ae7

Our research focuses on understanding how the genetic makeup of cancer and the heterogeneity in the tumor microenvironment (TME) influences cancer progression, metastasis, and therapy resistance at the molecular and cellular levels. Our long-term goal is to translate the basic findings in the laboratory into drug discovery and patient care.

We employ a multi-disciplinary approach that includes:

Unbiased computational analyses of multi-OMICS data (transcriptomics, epigenomics, proteomics, and metabolomics)

Genetically engineered mouse models (GEMMs)

Cross-species and integrative analyses of human and mouse OMICS data

Importantly, we utilize cutting-edge single-cell technologies in our research, including CyTOF, single-cell RNA-seq, single-cell ATAC-seq, and imaging mass cytometry.

The research team includes 2 research scientists, 1 postdoctoral fellow, 1 senior research assistant, and 5 undergraduate students.

If you are passionate about cancer research or interested in going to graduate school or medical school, and looking for an opportunity to gain hands-on experience in a dynamic, innovative lab environment, this position could be a perfect fit for you.

Apply here:

https://jobs.mdanderson.org/search/jobdetails/research-assistant-i—gu-medical-oncology/3308858c-846c-4686-a771-53395fbdbc03

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Research assistant i - cancer biology, 🔍 united states, texas, houston, houston (tx med ctr).

Required: Bachelor's degree, major course work in one of the basic sciences.

Required: No experience.

Preferred Willingness to work with mice.

It is the policy of The University of Texas MD Anderson Cancer Center to provide equal employment opportunity without regard to race, color, religion, age, national origin, sex, gender, sexual orientation, gender identity/expression, disability, protected veteran status, genetic information, or any other basis protected by institutional policy or by federal, state or local laws unless such distinction is required by law. http://www.mdanderson.org/about-us/legal-and-policy/legal-statements/eeo-affirmative-action.html

  • Requisition ID: 151508
  • Employment Status: Full-Time
  • Employee Status: Regular
  • Work Week: Days
  • Minimum Salary: US Dollar (USD) 31,200
  • Midpoint Salary: US Dollar (USD) 39,000
  • Maximum Salary : US Dollar (USD) 46,800
  • FLSA: non-exempt and eligible for overtime pay
  • Fund Type: Soft
  • Work Location: Onsite
  • Pivotal Position: Yes
  • Science Jobs: Yes

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Key searches, using ai, usc researchers pioneer a potential new immunotherapy approach for treating glioblastoma.

A team of researchers from USC Norris Comprehensive Cancer Center built a machine learning system to identify genes that can convert brain cancer cells into functioning immune cells and successfully tested the approach in a mouse model.

Researchers leveraged AI to identify the fate driver genes that can transform glioblastoma cells into dendritic cells, which can help target the cancer for destruction. Study author David Tran created this image using ChatGPT.

In an innovative new study of glioblastoma, scientists used artificial intelligence (AI) to reprogram cancer cells, converting them into dendritic cells (DCs), which can identify cancer cells and direct other immune cells to kill them.

Glioblastoma is the most common brain cancer in adults and also the deadliest, with less than 10% of patients surviving five years after their diagnosis. While new approaches such as immunotherapy have revolutionized treatment for other cancers, they have done little for patients with glioblastoma. That is partly because these hard-to-reach brain tumors hide behind the blood-brain barrier, where immune cells struggle to reach and eliminate them.

But new research, supported in part by the National Institutes of Health and led by the Keck School of Medicine of USC, has leveraged AI to explore which genes control a cell’s fate—whether it develops into a heart cell, a lung cell or a cancer cell, for instance. The researchers identified genes that can reprogram glioblastoma cells, converting them into immune cells within the tumor itself so they effectively target their kin cancer cells for destruction.

In mouse models of glioblastoma, the approach increased the chances of survival by up to 75%. The results were just published in Cancer Immunology Research , a journal of the American Association for Cancer Research.

“This groundbreaking study leverages the power of AI to transform glioblastoma cells into immune-activating cells, marking a significant advancement in cancer immunotherapy,” said the study’s lead author David Tran, MD, PhD , an associate professor of neurological surgery and neurology and division chief of neuro-oncology at the Keck School of Medicine. “By turning the cancer’s own cells against it, we are paving the way for more effective treatments and offering new hope to patients battling this and many other aggressive cancers.”

In addition to their work in animal models, researchers used AI to identify a set of genes that can convert human glioblastoma cells into immune cells. In the future, scientists could deliver that genetic material to glioblastoma patients by embedding it within an innocuous virus, a tool known as a viral vector.

“Forcing a cell with 20,000 genes to become something else is incredibly complex. Using traditional molecular approaches, it would be almost impossible to do,” said Tran, who also co-directs the USC Brain Tumor Center at USC Norris Comprehensive Cancer Center. “AI is helping us answer some critical questions and gives us a powerful way to learn how to manipulate a cell’s fate.”

Controlling the fate of a cell

DCs play a central role in activating the immune response: They sample antigens (such as from a cancer cell) and present them to other immune cells, including armies of T-cells, effectively triggering a full-scale attack.

Evidence suggests that DCs can fight glioblastoma, but scientists have not yet found a reliable way to get them past the blood-brain barrier and into the hostile environment of a tumor. By reprogramming cancer cells already located within the tumor, Tran and his team have bypassed this major challenge.

When manipulating the fate of a cell, one important consideration is specificity. Converting healthy brain cells into DCs, for example, could shrink a brain tumor but cause health problems.

“We don’t want to give something to a patient that can convert all sorts of cells into DCs,” Tran said.

The machine learning system he and his team developed was able to query tens of thousands of genes and millions of gene-to-gene connections and identify those that can specifically target glioblastoma cells and reprogram them to resemble DCs. This AI-driven method differs from previous research, which used what is known as an empirical approach to manually identify genes that control a cell’s fate.

‘The high computational power of AI is really helping us accelerate the discovery process,” Tran said.

Used alongside other immunotherapies, reprogramming glioblastoma cells significantly enhanced the immune response and survival rates in mouse models of glioblastoma. When combined with immune checkpoint therapy, the new approach improved the chance of survival by 75%. When combined with a classic DC vaccine, the new approach doubled the chance of survival. (Used alone, neither immune checkpoint therapy nor a DC vaccine increased the chance of survival in patients with glioblastoma.)

Moving toward clinical trials  

In addition to the proof-of-concept study in mice, the researchers used their AI system to identify a set of human genes that can convert human glioblastoma cells into cells resembling DCs. Next, they plan to fine-tune that list, package the genetic material into a viral vector and begin an initial round of safety and efficacy tests in animal models.

“We want to expand the search, using AI to help us find the best possible combinations as we move toward testing in patients,” Tran said.

If the approach is deemed safe and effective—meaning it improves outcomes for glioblastoma models and does not cause unexpected side effects—Tran and his team will apply for approval to begin clinical trials in patients in several years. Down the line, they also hope to use their AI model to find genes that can reprogram other types of cancer cells to behave like DCs.

About this research

In addition to Tran, the study’s other authors are Tianyi Liu, Son B. Le and Dongjiang Chen from the Division of Neuro-Oncology, Departments of Neurological Surgery and Neurology and the USC Brain Tumor Center, Keck School of Medicine of USC, University of Southern California; and Dan Jin, Mathew Sebastian, Alberto Riva and Ruixuan Liu from the University of Florida College of Medicine, Gainesville, Florida.

This work was supported by the National Cancer Institute of the National Institutes of Health [R42CA228875, R01CA238387, P30CA014089 and F30CA232641] and the Bankhead Coley Research Program of the Florida Department of Health [6BC04].

Disclosure: Tran and Le are inventors of two patent applications [62/952,725 and 62/586,655] based on the data in this manuscript.

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Ramakrishnan “Ram” Gopalakrishnan and Preet Chaudhary review images related to their study of primary effusion lymphoma (PEL)

  • Press Release
  • USC Norris Comprehensive Cancer Center

Senior Research Assistant - Cancer Biology (Kalluri Laboratory)

  • Requisition #: 156504
  • Location: Houston, TX
  • Posted Date: 6/3/2024
  • Exercises considerable imagination, initiative and inventiveness in planning and executing the details of experiments/studies and in evaluating and interpreting the results.
  • Responsible for major participation in the development and revision of techniques, assembles and operates laboratory apparatus and equipment.
  • Performs regular monitoring of safety standards in the laboratory and maintains records of hazardous materials.
  • Perform laboratory studies using complex techniques including large-scale tissue culture (maintaining mammalian cells, growth assays, drug response assays, transfection and viral infection), nucleic acid extraction, PCR analyses, immunoblotting, immunocytochemistry and immunohistochemistry.
  • Performing cloning studies, gene editing using CRISPR/Cas9 technology, RNAi transfections studies, screening assays, and flow cytometry.
  • Collaborates or assists with supervisor and senior research staff with the preparation of reports and grant requests.
  • Supervises technicians in their work and assists them as assigned or delegated.
  • Assists new members of the laboratory/department in the use of nude mice and tissue culture techniques.
  • Orders and organizes supplies for the laboratory.
  • Maintaining supply levels and safety standards in the laboratory as well as for training other personnel in special techniques.
  • Requisition ID: 156504
  • Employment Status: Full-Time
  • Employee Status: Regular
  • Work Week: Days
  • Minimum Salary: US Dollar (USD) 48,400
  • Midpoint Salary: US Dollar (USD) 60,500
  • Maximum Salary : US Dollar (USD) 72,600
  • FLSA: exempt and not eligible for overtime pay
  • Fund Type: Soft
  • Work Location: Onsite
  • Pivotal Position: Yes
  • Referral Bonus Available?: No
  • Relocation Assistance Available?: Yes
  • Science Jobs: Yes

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Making Cancer History

© 2024 The University of Texas MD Anderson Cancer Center

21607-Lu, Tao

Tao Lu, PhD

Associate Professor of Pharmacology & Toxicology

Adjunct Associate Professor of Biochemistry & Molecular Biology

Adjunct Associate Professor of Medical & Molecular Genetics

Showalter Scholar

Member of "Woman Advisory Council" at IUSM

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Dr. Tao Lu has an extensive background in signaling transduction, molecular and cellular biology, biochemistry, genetics, and pharmacology with specific expertise in NF-kB signaling, post-translational modification, cancer epigenetics, and drug discovery. Born in a physician and medical professor’s family, Dr. Lu was fascinated by medical science from a very young age. She studied signaling transduction in cell death during her graduate study with Dr. Ronald L. Mellgren. Her postdoctoral training was with the world renowned cancer biologist and geneticist Dr. George R. Stark, who discovered Interferon/JAK/Stat pathway. Dr. Lu was an Assistant Professor at Lerner College of Medicine at Case Western Reserve University (CWRU) before she relocated to Indianapolis. She now is an Associate Professor with tenure at Department of Pharmacology & Toxicology, and an adjunct Associate Professor at Department of Biochemistry & Molecular Biology, as well as Department of Medical and Molecular Genetics. Dr. Lu is also a full member of the Experimental and Developmental Therapeutics (EDT) Program at IU Simon Cancer Center (IUSCC) - a National Cancer Institute (NCI)-Designated Comprehensive Cancer Center. 

 

2019-present

 

2019-present

, Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN

, Department of Biochemistry and Molecular Biology/Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN

2012-2018

, Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN

2012-2018

, Department of Biochemistry and Molecular Biology/Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN

2009-2011

in Molecular Medicine, Lerner College of Medicine at Case Western Reserve University (CWRU), Cleveland, OH

2006-2011

, Department of Molecular Genetics, Cleveland Clinic, Cleveland, OH

2003-2011

Department of Molecular Genetics, Cleveland Clinic, Cleveland, OH

 

2018

 "Cancer-2018", International Conference on Cancer Research

2017

Indiana University School of Medicine, Indianapolis, IN

2016

, Indiana University School of Medicine, Indianapolis, IN

2015

, The Larry Gentry Research Forum, University of Toledo School of Medicine, Toledo, OH

2015

, Indiana University School of Medicine, Indianapolis, IN

2015

, Indiana University, Indianapolis, IN

2014

 in Cancer Research, Indiana University, Indianapolis, IN

2014

, International Cytokine and Interferon Society Conference 

2013

, Indiana University, Indianapolis, IN

2013

 twice

2012

, Indiana University Walther Oncology Center, Indianapolis, IN

2009

, Tri-Society [Society of Leukocyte Biology (SLB) & ICS & ISICR] Conference 

2008

, International Society of Interferon & Cytokine Research (ISICR) & ICS Conference 

2007

, Cleveland Clinic, Cleveland, OH 

2007

International Cytokine Society (ICS) Conference 

2004

, International Society of Interferon & Cytokine Research (ISICR) Conference 

2004

, Cleveland Clinic, Cleveland, OH

2000

, University of Toledo School of Medicine, Toledo, OH 

International Professional Activities

Reviewer           

(selected from over 20 journals): Molecular Cellular Biology (MCB), Proc Natl Acad Sci (PNAS), Oncogene, Cancer Research, FASEB J, Scientific Report, Cancer Letter, J Virology, European Journal of Cell Biology  (EJCB)

Member   

Advisory Board, International BIT Annual World Congress of Molecular and Cellular Biology

Reviewer           

Medical Research Council (MRC), England

Co-Chair           

2nd International Summit on Integrative Biology

Session Chair    

International Conference on Retroviruses and Novel Drugs

Reviewer           

Austrian Science Fund (FWF), Austrian Special Research Program (SFB)

Member             

Editorial Board, Journal of Clinical Pharmacology and Toxicology (JCPT)

Reviewer           

The Welcome Trust/DBT India Alliance, Biomedical Fellowship Program

Member             

Editorial Board, Journal of Pharmacology Research and Toxicology

Member              

Editorial Board, Clinical Cancer Drugs

Member              

Editorial Board, The Journal of Gastroenterology & Digestive Systems

Member             

Editorial Board, SM Journal of Carcinogenesis & Mutagenesis

Member             

Editorial Board, Journal of Gastroenterology, Hepatology, and Endoscopy

Member             

Editorial Board, The Scientific Pages of Drug Design and Development

Session Chair     

International Conference for Biomarkers and Clinical Research

 

Patent Applications

Lu, T  and Prabhu, L. Small molecule protein arginine methyltransferase 5 (PRMT5) inhibitors and methods of treatment. International Patent Application PCT/US2017/058572, filed on October 26, 2017

Lu, T  and Prabhu, L. Small molecule protein arginine methyltransferase 5 (PRMT5) inhibitors and methods of treatment. U.S. Provisional Patent Application 62/534,969, filed on July 20, 2017

Lu, T  and Prabhu, L. Small molecule protein arginine methyltransferase 5 (PRMT5) inhibitors and methods of treatment. U.S. Provisional Patent Application 62/413,341, filed on October 26, 2016

Lu, T  and Stark GR. Discovery of the FBXL11 as the negative regulator of NFkB. Filed to the Cleveland Clinic Invention Disclosure in July, 2007, in the process of provisional patent application.

Lu, T , Burdelya, LG, Stark GR and Gudkov AV. Methods of inhibiting apoptosis using latent TGFb.  U.S. provisional Patent No. 60/526,667, filed December 2, 2004.

Key Publications

Selected from ~60 publications, Complete list of published work can be found at:

http://www.ncbi.nlm.nih.gov/myncbi/browse/collection/48581694/?sort=date&direction=descending

1. Prabhu, L, Wei, H, Chen, L, Ozlem, D, Amero, A, Sandusky, G, Sun, E, Wang, J, Mo, J, Safa, A, Korc, M, Zhang, Z, and Lu, T *. Innovative AlphaLISA discovers a novel small-molecule inhibitor targeting PRMT5 in pancreatic and colon cancers. Oncotarget 8(25): 39963-39977, 2017. * Corresponding author. - 1) Featured on front cover, Priority Paper, 2) Honorable Mention Award, Cancer Research Day, 3)  Honorable Mention, Erica M. Daniel Kepner Award for Scientific Achievement

2. Martin, M, Hua, L, Wang, B, Wei, H, Prabhu, L, Hartley, AV, Jiang, G, Liu, Y, and  Lu, T *. Novel serine 176 phosphorylation of YBX1 activates NF-kB in colon cancer.  J Biol Chem   292 (8): 3433-3444, 2017. * Corresponding author

3. Wang, B, Wei, H, Prabhu, L, Zhao, W, Martin, M, Hartley, A, and Lu, T *. Role of novel serine 316 phosphorylation of the p65 subunit of NF-kB in differential gene regulation. J Biol Chem 290 (33): 20336-20347, 2015 * Corresponding author - Selected for Donald Bowman Award

4.  Lu, T * and Stark, GR*. NF-kB, regulation by methylation. Cancer Res 75 (18): 3692-3695, 2015. * Corresponding authors

5. Wei, H, Wang, B, She, Y, Gopalan, B, Miyagi, M, Stark, GR, and  Lu, T *. PRMT5 dimethylates R30 of the p65 subunit to activate NF-kB.  Proc Natl Acad Sci USA  110:13516-13521, 2013. *Corresponding Author.  - 1) Selected for F1000 Prime, 2) Hal Broxymeyer & Victoria Champion Outstanding Publication Award, 3) 2nd Place Award, Cancer Research Day

6.  Lu, T *, Yang, M, Huang, D, Ghosh, G, and Stark GR. Role of lysine methyaltion of NF-kB in differential gene regulation. Proc Natl Acad Sci USA 110: 13510-13515, 2013. *Corresponding author - Selected for F1000 Prime

7. Zhang, T, Park, KA, Li, Y, Byun, HS, Jeon, J, Lee, Y, Hong, JH, Kim, JM, Huang, SM, Choi, SW, Kim, SH, Sohn, KC, Ro, H, Lee, JH, Lu, T , Stark, GR, Shen, HM, Liu, ZG, Park, J, and Hur, GM. PHF20 regulates NF-κB signalling by disrupting recruitment of PP2A to p65.  Nat Commun  4:2062-2074, 2013. 

8. Stark, GR, Wang, Y, and Lu, T . Lysine methylation of promoter-bound transcription factors and relevance to cancer. Cell Res  21(3):375-380, 2011.

9.  Lu, T *, Jackson, MW, Wang, B, Yang, M, Chance, M, Miyagi, M, Gudkov, AV, and Stark, GR*. Regulation of NF-kB by NSD1/FBXL11-dependent reversible lysine methyaltion of p65.  Proc Natl Acad Sci USA  107: 46-51, 2010 *Corresponding authors

10.  Lu, T and Stark, GR. Use of forward genetics to discover novel regulators of NF-kB. Book Chapter in Book "NF-kB". Editors: Michael Karin and Lou Staudt, Cold Spring Harbor Press , p253-264, 2010.

Default table
Year Degree Institution
2003 Postdoctoral Training Cleveland Clinic
2002 PhD University of Toledo
1994 MS Shandong University
1991 BS Nanjing University

Please visit Dr. Tao Lu's laboratory website for more information:

https://marti336.wixsite.com/taolulab

The research in my lab centers on the multi-functional transcription factor nuclear factor κB (NF-κB). As a hallmark in many cancers and a key link between inflammation and cancer, the pivotal transcription factor NF-κB is a “hot” target for disease treatment. My research focuses on addressing how NF-κB is regulated and how this regulation contributes to tumorigenesis. Ultimately, these studies may provide a rational basis for the design of new strategies for treating NF-κB-activated cancers and inflammatory disorders.

ACTIVE RESEARCH:

Two major directions of research are being conducted in our lab.

1) Epigenetic regulation of NF-κB in cancer.

We have discovered that the histone modifying enzymes, such as protein arginine methyltransferase 5 (PRMT5) and the F-box leucine repeat rich protein 11 (FBXL11), a known histone H3 lysine 36 (H3K36) demethylase are novel regulators of NF-κB. Currently, we are studying the role of these histone modifying enzymes in cancer. Specifically, we have adapted the AlphaLISA technique into a high throughput screen platform to screen for PRMT5 small molecule inhibitors. This work has resulted in two US Provisional Patents and one International Patent application. The lead compound and its derivatives may serve as the basis for new medicine development to combat cancer.

Furthermore, since elevated NF-κB activity has been widely observed in both chronic inflammatory bowel disease (IBD) and colitis-associated colon cancer (CAC), and is believed to be a key link between IBD and CAC, therefore, NF-κB is widely considered to be an attractive therapeutic target for CAC. We have successfully established genetically engineered mouse models to investigate the role of the role of FBXL11 in CAC and other inflammation related diseases, such as diabetes and atherosclerosis.

2) Using Validation-based insertional mutagenesis (VBIM) technique to discover novel genes.

VBIM is a powerful genetic approach for gene discovery. We have employed this innovative approach to identify novel regulators of NF-κB. These regulators may have great potential to serve as new biomarkers and therapeutic targets for cancer. Furthermore, understanding the underlying molecular mechanisms regarding how these novel regulators control NF-κB activity may help to devise innovative therapeutic strategies to control NF-κB activity in cancer.   

Additionally, our lab is also utilizing VBIM technique to discover carboplatin and paclitaxel resistance genes in cancer. Once identified, targeting these genes may help to overcome chemoresistance to carboplatin or paclitaxel, thus, improving their efficacies for cancer treatment. Finally, the newly discovered drug resistance genes may serve as biomarkers to help physicians to design more precise treatment to each individual patient.

In conclusion, the research in our lab utilizes a broad range of advanced research techniques and experimental models to discover novel aspects of NF-κB regulation and new genes for drug resistance, with the hope of identifying innovative biomarkers, therapeutic targets in cancer and other NF-κB related diseases, and eventually, lead to the development of new medicines to treat these devastating diseases.

RESEARCH FUNDING:

NIH-NIGMS Grant # 1R01GM120156-01A1

Role: Principle investigator

Project Title: Gene-specific responses to NF-κB through lysine and arginine methylation of p65

NIH-NCI Grant # 1 R03 CA223906-01

Role: Leading Principle Investigator (with Dr. Harikrishna Nakshatri)

Project Title: Impact of NF-κB methylation on chemoresistance and metastasis of breast cancer

V Foundation Kay Yow Cancer Fund 4486242

Role: Principle Investigator

Project Title: Facing the challenge, a novel approach to combat carboplatin resistance in ovarian cancer

100 VOH Grant # 2987613

Role: Leading Principle Investigator (with Dr. Lang Li)

Project Title: A novel approach to discover drug resistance genes in metastasized breast cancer cells

Professional Organizations

Looking for patient care.

IMAGES

  1. Celia LUJAN

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  2. Senior Research Assistant

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  3. Vacancy for Research Assistant in Cancer Cell Biology at Tata Medical

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  4. Senior Research Assistant

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  5. Institute of Cancer Research

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  6. Data science pairs with cancer research for better diagnostics

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VIDEO

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  5. Fully Funded PhD in Pharmacology and Cancer Biology, at Duke University

  6. In our 'In Focus' Series, we present "The Cancer Biology Laboratory" in the FLSB

COMMENTS

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